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40749-33-5

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40749-33-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 40749-33-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,7,4 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 40749-33:
(7*4)+(6*0)+(5*7)+(4*4)+(3*9)+(2*3)+(1*3)=115
115 % 10 = 5
So 40749-33-5 is a valid CAS Registry Number.

40749-33-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(hydroxymethyl)-2-pyrimidinecarboxaldehyde

1.2 Other means of identification

Product number -
Other names 2-formyl-5-(hydroxymethyl)pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40749-33-5 SDS

40749-33-5Relevant articles and documents

Synthesis of functionalized hexadentate iminopyridine FeII complexes - Toward anion-dependent spin switching in polar media

McDaniel, Ashley M.,Klug, Christina M.,Shores, Matthew P.

, p. 943 - 950 (2013)

We report the syntheses and characterizations of low-spin FeII complexes of hexadentate ligands poised for aniontriggered spin-state switching in polar solutions: [Fe(L5-OH)]- (BF4)2 (1) and [Fe(L5-ONHtBu)](BF4)2 (3), in which L5-OH and L5-ONHtBu are tripodal iminopyridine ligands that contain methanolic or tert-butylamide functional groups, respectively, bound meta to the pyridyl N donor atom. Solid-state evidence for strong hydrogen bonding between Cl- anions and all three amide functional groups in [Fe(L5-ONHtBu)]2+ is provided by the crystal structure of {[Fe(L5-ONHtBu)]∪Cl} 2- [FeCl4] (2). In ambient-temperature acetonitrile solutions of 1 and 3, chloride ion titrations produce marked changes in the 1H NMR spectra, including large downfield shifts for the amide NH and hydroxy OH resonances, which indicates strong anion binding events. Interestingly, for amide-containing 3, we observe small changes in magnetic susceptibility as (nBu4N)Cl is added, which suggests that spin-state control by anion-cation interactions may be accessible for related compounds with weaker ligand fields.

New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action

Ohui, Kateryna,Afanasenko, Eleonora,Bacher, Felix,Ting, Rachel Lim Xue,Zafar, Ayesha,Blanco-Cabra, Núria,Torrents, Eduard,D?m?t?r, Orsolya,May, Nóra V.,Darvasiova, Denisa,Enyedy, éva A.,Popovi?-Bijeli?, Ana,Reynisson, Jóhannes,Rapta, Peter,Babak, Maria V.,Pastorin, Giorgia,Arion, Vladimir B.

supporting information, p. 512 - 530 (2019/01/04)

Six morpholine-(iso)thiosemicarbazone hybrids HL1-HL6 and their Cu(II) complexes with good-to-moderate solubility and stability in water were synthesized and characterized. Cu(II) complexes [Cu(L1-6)Cl] (1-6) formed weak dimeric associates in the solid state, which did not remain intact in solution as evidenced by ESI-MS. The lead proligands and Cu(II) complexes displayed higher antiproliferative activity in cancer cells than triapine. In addition, complexes 2-5 were found to specifically inhibit the growth of Gram-positive bacteria Staphylococcus aureus with MIC50 values at 2-5 μg/mL. Insights into the processes controlling intracellular accumulation and mechanism of action were investigated for 2 and 5, including the role of ribonucleotide reductase (RNR) inhibition, endoplasmic reticulum stress induction, and regulation of other cancer signaling pathways. Their ability to moderately inhibit R2 RNR protein in the presence of dithiothreitol is likely related to Fe chelating properties of the proligands liberated upon reduction.

Aromatic Retinoic Acid Analogues. 2. Synthesis and Pharmacological Activity

Dawson, Marcia I.,Chan, Rebecca,Hobbs, Peter D.,Chao, Wan-ru,Schiff, Leonard J.

, p. 1282 - 1293 (2007/10/02)

Aromatic analogues of (E)-1-(4-carboxyphenyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene (1b) and its ethyl ester (1a) were synthesized as potential chemopreventive agents for the treatment of epithelial cancer and such skin diseases as psoriasis and cystic acne.The phenyl ring of 1 was replaced by 2-fluorophenyl, 2-methoxyphenyl, thienyl, furanyl, and pyridyl groups.The 1-fluorobutadiene analogue of 1 was also synthesized.With exception for the furanyl analogue, these compounds demonstrated good activity in reversing keratinization in hamster tracheal organ culture and in inhibiting the induction of ornithine decarboxylase in mouse epidermis by a tumor promoter.

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