50501-35-4

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 5-(hydroxyMethyl)picolinate is used as an intermediate in the synthesis of various pharmaceuticals for its potential reactivity and ability to participate in chemical reactions, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Ethyl 5-(hydroxyMethyl)picolinate is used as a building block in the synthesis of agrochemicals, such as pesticides and herbicides, due to its potential reactivity and ability to form various chemical compounds.
Used in Medicinal Chemistry:
Ethyl 5-(hydroxyMethyl)picolinate is used as a versatile chemical compound in medicinal chemistry for its potential to participate in various chemical reactions, aiding in the discovery and development of novel therapeutic agents and drug candidates.

Upstream product

• 64-17-5 ethanol 
• 39977-41-8 5-(hydroxymethyl)picolinic acid 
• 53574-57-5 5-formyl-2-pyridine carboxylic acid ethyl ester 
• 50501-34-3 GENERIC INORGANIC CATION; 5-ethoxycarbonyl-pyridine-2-carboxylate 
• 100-26-5 Pyridine-2,5-dicarboxylic acid 
• 21514-99-8 2,5-bis[hydroxymethyl]-pyridine 
• 5552-44-3 ethyl 2,5-pyridinedicarboxylate 
• 40749-33-5 5-(hydroxymethyl)-2-pyrimidinecarboxaldehyde 
• 4434-13-3 2-carboxy-5-methylpyridine 
• 55876-82-9 5-methyl-2-pyridinecarboxylic acid-ethyl ester 
• 589-93-5 2,5-dimethylpyridine 
• 55876-85-2 5-(Dibrommethyl)-2-pyridincarbonsaeure-ethylester 
• 7722-84-1 dihydrogen peroxide 
• 881-86-7 dimethyl 2,5-pyridine dicarboxylate 

Downstream Products

• 39977-48-5 5-Chlormethyl-2-pyridincarbonsaeure-ethylester 
• 70990-98-6 5-{2-Methoxycarbonyl-2-[2-(toluene-4-sulfonyl)-ethoxycarbonylamino]-ethyl}-1-oxy-pyridine-2-carboxylic acid methyl ester 
• 70990-90-8 N-(p-Tolylsulfonylethoxycarbonyl)-3-(2-methoxycarbonyl-5-pyridyl)alanin-methylester 
• 86238-83-7 (E)-1-(2-carbethoxy-5-pyridyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene 

Relevant academic research and scientific papers

CONJUGATES OF ARTEMISININ-RELATED ENDOPEROXIDES AND HYDRAZONE DERIVATIVES FOR THE TREATMENT OF CANCER

Compounds having an artemisinin-related endoperoxide moiety covalently coupled to a hydrazone moiety through a linker. Compositions and methods for treating cancer using the compounds.

NOVEL BENSOPHENONE DERIVATIVES OR SALTS THEREOF

A benzophenone derivative represented by the following formula: whereinR1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl;R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, ???or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.

N-heterocyclic retinoic acid analogues

A compound of the formula: STR1 where X is STR2 and R is hydroxy, or an alkoxy with 0 or 1 hydroxy substituent, or aroxy with 0 or 1 hydroxy substituent, or alkoxy monosubstituted phenoxy, or NR 1 R 2 where R 1 is hydrogen, or an alkyl or aryl with 0 or 1 hydroxy substituent, and R 2 is an alkyl or aryl with 0 or 1 hydroxy substituent. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in ephithelial cells and for treating nonmalignant skin disorders.

Aromatic Retinoic Acid Analogues. 2. Synthesis and Pharmacological Activity

Aromatic analogues of (E)-1-(4-carboxyphenyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene (1b) and its ethyl ester (1a) were synthesized as potential chemopreventive agents for the treatment of epithelial cancer and such skin diseases as psoriasis and cystic acne.The phenyl ring of 1 was replaced by 2-fluorophenyl, 2-methoxyphenyl, thienyl, furanyl, and pyridyl groups.The 1-fluorobutadiene analogue of 1 was also synthesized.With exception for the furanyl analogue, these compounds demonstrated good activity in reversing keratinization in hamster tracheal organ culture and in inhibiting the induction of ornithine decarboxylase in mouse epidermis by a tumor promoter.

Colouring Matters from Fly Agaric, VII. - Constitution and Synthesis of Muscaflavin

The constitution of the yellow dihydroazepine amino acid muscaflavin, isolated from mushrooms, has been established as 1a.This was confirmed by a biomimetic synthesis of the DL ester 1b, starting from pyridylalanine 12a via the glutaconic dialdehyde inter