40773-58-8Relevant academic research and scientific papers
Studies related to synthesis of glycophosphatidylinositol membrane-bound protein anchors. 6. Convergent assembly of subunits
Madsen, Robert,Udodong, Uko E.,Roberts, Carmichad,Mootoo, David R.,Konradsson, Peter,Fraser-Reid, Bert
, p. 1554 - 1565 (2007/10/02)
Glycophosphatidylinositol anchors of membrane-bound proteins are thought to comprise a common pentasaccharide core containing mannan, glucosamine, and inositol residues. A synthetic route to this core is described. In addition, the complete heptasaccharide moiety of the rat brain Thy-1 membrane anchor, the first mammalian membrane anchor to be characterized, has been synthesized. In the case of the Thy-1 anchor, the synthetic plan is based on three building blocks comprising glucosamine-inositol, galactosamine-mannose, and trimannan residues. Although glycosyl donors other than n-pentenyl glycosides (NPGs) have been used in preparing each of these building blocks, the final assembly of the heptasaccharide utilizes NPGs as the only glycosyl donors. The mildness of the conditions for these coupling reactions has allowed us to make provisions for subsequent installation of the three phosphodiester units.
Synthesis of (+/-) Myo-Inositol-1-O-Methylphosphonate-4,5-Bis(phosphate), an Analogue of D-Myo-Inositol-1,4,5-Tris(phosphate).
Schmitt, Laurent,Spiess, Bernard,Schlewer, Gilbert
, p. 7059 - 7060 (2007/10/02)
The synthesis of (+/-) myo-inositol-1-O-methylphosphonate-4,5-bis(phosphate) is reported.This compound is analogue of D-myo-inositol-1,4,5-tris(phosphate) in which the phosphate group in position 1 is replaced by a methyl phosphonate function and where the important vicinal phosphate groups in positions 4 and 5 are preserved.
Synthesis and Tritium Radiolabelling of Fluorinated Analogues of myo-Inositol
Offer, John L.,Voorheis, H. Paul,Metcalfe, James C.,Smith, Gerry A.
, p. 953 - 960 (2007/10/02)
Syntheses have been developed for a set of six myo-inositol analogues from myo-inositol in which single hydroxy groups have been replaced by fluorine (monodeoxy-fluoro-myo-inositols).Except for 2-deoxy-2-fluoro-myo-inositol 32 and 1D-4-deoxy-4-fluoro-myo-
THE TOTAL SYNTHESIS OF myo-INOSITOL POLYPHOSPHATES
Vacca, Joseph P.,deSolms, S. Jane,Huff, Joel R.,Billington, David C.,Baker, Raymond,et al.
, p. 5679 - 5702 (2007/10/02)
Total synthesis of the individual enentiomers of myo-inositol 4-phosphate (15), myo-inositol 1,4-biphosphate (2) and myo-inositol 1,4,5-triphosphate (1), together with syntheses of racemic myo-inositol 1,3,4-triphosphate (4) and myo-inositol 2,4,5-triphos
SYNTHESIS OF SOME BENZYL AND METHYL ETHERS OF myo-INOSITOL
Garegg, Per J.,Lindberg, Bengt,Kvarnstroem, Ingemar,Svensson, Stefan C. T.
, p. 205 - 216 (2007/10/02)
The 1D and 1L forms of 1,2,4,5,6- and 1,2,3,4,5-penta-O-methyl-myo-inositol have been prepared from the corresponding chiral mono-O-benzyl derivatives.Convenient preparations are also described of achiral derivatives of 1-, 2-, 4-, and 5-O-benzyl-myo-inos
THE PREPARATION OF CYCLOHEXANEPENTOLS FROM INOSITOLS BY DEOXYGENATION
Angyal, Stephen J.,Odier, Leon
, p. 209 - 220 (2007/10/02)
Several cyclohexapenetols heva been synthesized from inositols by blocking all but one hydroxyl group, converting the free hydroxyl group into its S-methyl dithiocarbonate, and treating it with tributylstannane.Suitable blocking-groups are methyl, benzyl, and methylthiomethyl ethers, and acetals.One cyclohexanepentol was prepared by the reductive deamination of an aminodeoxyinositol.
