40971-36-6

Basic information

• Product Name: 1,2,3,4-Tetrahydro-2-quinolinemethanol
• Synonyms: 1,2,3,4-Tetrahydro-2-quinolinemethanol;(1,2,3,4-tetrahydroquinolin-2-yl)methanol;2-Hydroxymethyl-1,2,3,4-tetrahydroquinoline;(2S)-1,2,3,4-Tetrahydro-2-quinolinylMethanol;2-Quinolinemethanol, 1,2,3,4-tetrahydro-;(1,2,3,4-Tetrahydroquinolin-2-yl)
• CAS NO: 40971-36-6
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• EINECS: -0
• Mol File: 40971-36-6.mol

Chemical Properties

• Boiling Point: 327.731 °C at 760 mmHg
• Flash Point: 163.332 °C
• Appearance: /
• Density: 1.081
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-2-quinolinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-2-quinolinemethanol(40971-36-6)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-2-quinolinemethanol(40971-36-6)

Safety Data

• Hazardous Substances Data: 40971-36-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1,2,3,4-Tetrahydro-2-quinolinemethanol is utilized as a reagent in organic synthesis, contributing to the formation of various complex organic compounds due to its unique chemical structure and reactivity.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 1,2,3,4-Tetrahydro-2-quinolinemethanol serves as an intermediate, playing a crucial role in the synthesis of a range of medicinal compounds.
Used in Agrochemical Production:
Similarly, in agrochemicals, 1,2,3,4-Tetrahydro-2-quinolinemethanol is employed as an intermediate, aiding in the development of products designed to protect and enhance crop yields.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
1,2,3,4-Tetrahydro-2-quinolinemethanol is also recognized for its potential as a chiral auxiliary, which is instrumental in asymmetric synthesis to produce enantiomerically pure compounds, a critical aspect in the production of many pharmaceuticals.
Used in Pain Relief Research:
1,2,3,4-Tetrahydro-2-quinolinemethanol has been investigated for its potential as a pain reliever, indicating its possible use in the development of new analgesics.
Used in Antimalarial Drug Development:
Furthermore, 1,2,3,4-Tetrahydro-2-quinolinemethanol has shown promise in antimalarial research, suggesting its potential incorporation into future treatments for malaria.
Overall, 1,2,3,4-Tetrahydro-2-quinolinemethanol's diverse applications across various industries highlight its importance in the fields of chemistry, medicine, and agriculture.

Upstream product

• 5470-96-2 quinoline 2-carbaldehyde 
• 62-53-3 aniline 
• 91-63-4 2-methylquinoline 
• 24544-04-5 2,6-diisopropylbenzenamine 

Downstream Products

• 618113-62-5 2-Iodomethyl-1,2,3,4-tetrahydro-quinoline 
• 497959-02-1 [1-(4-chloro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl]-methanol 
• 497959-01-0 1-(4-chloro-benzenesulfonyl)-2-trimethylsilanyloxymethyl-1,2,3,4-tetrahydro-quinoline 
• 943995-83-3 C₁₆H₁₄NO₃SCl 
• 943995-84-4 C₁₈H₂₀NSO₃Cl 
• 955033-96-2 [(S)-1-(4-Chloro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl]-methanol 
• 955033-95-1 (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol 

Relevant articles and documents

Consecutive Intermolecular Reductive Amination/Asymmetric Hydrogenation: Facile Access to Sterically Tunable Chiral Vicinal Diamines and N-Heterocyclic Carbenes

A highly enantioselective iridium- or ruthenium-catalyzed intermolecular reductive amination/asymmetric hydrogenation relay with 2-quinoline aldehydes and aromatic amines has been developed. A broad range of sterically tunable chiral N,N′-diaryl vicinal diamines were obtained in high yields (up to 95 %) with excellent enantioselectivity (up to >99 % ee). The resulting chiral diamines could be readily transformed into sterically hindered chiral N-heterocyclic carbene (NHC) precursors, which are otherwise difficult to access. The usefulness of this synthetic approach was further demonstrated by the successful application of one of the chiral vicinal diamines and chiral NHC ligands in a transition-metal-catalyzed asymmetric Suzuki–Miyaura cross-coupling reaction and asymmetric ring-opening cross-metathesis, respectively.

Tricyclic quinoxalinediones

Tricyclic quinoxalinediones of the formula: STR1 wherein X is alkyl, halogen, cyano, trifluoromethyl, nitro, hydroxy, amino, etc.; R 1 is H, etc.; R 2 is H, alkyl, cycloalkyl, alkenyl, alkynyl, cycloalkylalkyl, arylalkyl, substituted arylalkyl, aryl, or substituted aryl; W is H, CO 2 R 3, CO 2 Y, CONR 3 R 4, CONR 3 Y, CON(OR 3)R 4, COR 3, CN, tetrazolyl, or substituted alkyl; R 3 and R 4 independently are H, alkyl, cycloalkyl, alkenyl, alkynyl, etc.; Y is mono-substituted alkyl or di-substituted alkyl; and n is an integer 0 or 1, or a pharmaceutically acceptable salt thereof, which are useful as a selective antagonist of glutamate receptor for the treatment or prevention of various diseases in animals including human being, for example, minimizing damage of central nervous system induced by ischaemic or hypoxylic conditions, treatment and/or prevention of neurodegenerative disorders, and further analgesics, antidepressants, anxiolitics, and anti-schizophrenics.