410092-91-0

Usage

Uses

Used in Dye and Pigment Production:
Benzenamine, 2-methoxy-N-methyl-6-nitrois used as a chemical intermediate in the production of dyes and pigments, contributing to the development of a wide range of colorants for various applications.
Used in Organic Synthesis:
Benzenamine, 2-methoxy-N-methyl-6-nitroserves as a building block in organic synthesis, enabling the creation of various complex organic compounds for different industries.
Used in Pharmaceutical Manufacturing:
Benzenamine, 2-methoxy-N-methyl-6-nitrois utilized in the manufacturing process of pharmaceuticals, playing a crucial role in the development of new drugs and medicinal compounds.
Used in Crop Protection Products:
It is also employed in the production of crop protection products, helping to develop effective solutions for agricultural applications and ensuring crop health and productivity.

Upstream product

• 445-68-1 2-fluoro-1-methoxy-3-nitrobenzene 
• 74-89-5 methylamine 
• 603-85-0 2-Amino-3-nitrophenol 
• 74-88-4 methyl iodide 
• 16315-07-4 2,3-dinitroanisole 
• 124-40-3 dimethyl amine 

Downstream Products

• 1403581-32-7 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N¹-methylbenzo[d]imidazole-4yl)oxazole 
• 106652-41-9 2-methoxy-N-methyl-4,6,N-trinitro-aniline 
• 1021915-14-9 3-methoxy-N²-methyl-o-phenylenediamine 

Relevant academic research and scientific papers

Synthesis and antiproliferative evaluation of novel benzoimidazole- contained oxazole-bridged analogs of combretastatin A-4

A series of novel oxazole-bridged analogs of combretastatin A-4 bearing a benzo[d]-imidazole as B ring were synthesized and evaluated for antiproliferative activities against five human cancer cell lines. Among all the synthesized compounds, the N-unsubstituted benzoimidazole analog 5 and the analogs 6b, 7a and 7b with a small hydrophobic group on nitrogen atom of benzoimidazole ring were identified as the most potent inhibitors of tumor cell growth with IC50 values at nanomolar levels (5, IC50 = 8.4 nM, HT29; 6b, 7a, 7b, IC50 = 9.6 nM, 3.8 nM, 3.0 nM, A549). In a murine H22 tumor xenograft model, compound 5 exhibited significant antitumor activity. The binding mode of compound 5 in the colchicine binding site of tubulin was probed.

THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.

Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3

High-throughput screening identified a low molecular weight antagonist of CXCR3 displaying micromolar activity in a membrane filtration-binding assay. Systematic modification of the benzimidazole core and tethered acetophenone moiety established tractable SAR of analogs with improved physicochemical properties and sub-micromolar activity across both human and murine receptors.

Construction of interconnected acidity functions based on ortho substituted anilines and N-methylanilines as indicators

The log I values of 15 mainly ortho substituted derivatives of aniline and N-methylaniline have been measured spectrophotometrically in sulfuric, perchloric, and methanesulfonic acids. A new algorithm has been suggested for construction of acidity functions enabling simultaneous and independent construction of acidity functions in various media under the condition of equal values of pKa of the same indicators in the given media. The so-called interconnected acidity functions have been constructed with using this algorithm and the log I values measured in the above media, and the pKa values have been calculated. The resulting acidity functions and pKa values agree well with the corresponding literature data.