41013-43-8

Upstream product

• 286-18-0 7-azabicyclo[4.1.0]heptane 
• 492-99-9 1,2-cyclohexanedionedioxime 
• 2802-07-5 1,3-cyclohexanedionedioxime 
• 108-45-2 m-phenylenediamine 
• 286-20-4 cyclohexane-1,2-epoxide 
• 286-18-0 7-azabicyclo<4.1.0>heptane 
• 110-83-8 cyclohexene 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 2562-37-0 1-nitrocyclohexene 
• 71172-32-2 trans-1,2-dinitrocyclohexane 

Downstream Products

• 92036-75-4 (+/-)-trans-N,N'-diisopropylcyclohexane-1,2-diamine 
• 30086-64-7 (3aS,7aS)-hexahydro-1H-benzo[d]imidazole-2(3H)-thione 
• 30086-64-7 trans-2-thiohexahydrobenzimidazole 
• 1121-22-8 trans-N,N,N′,N′-tetramethylcyclohexane-1,2-diamine 
• 133725-75-4 N-tert-butoxycarbonyl-N'-(trans-2-aminocyclohexyl)-p-nitrophenylalaninamide 
• 119492-53-4 (R)-trans-N,N'-dipyridoxylidene-1,2-cyclohexanediamine 
• 1123-97-3 (rac)-trans-4,5-tetramethyleneimidazolidin-2-one 
• 135039-14-4 trans-N,N'-Bis(2-aminocyclohexyl)propanediamide 
• 327050-72-6 1-Amino-2-(2,4-dinitrophenylamino)cyclohexane 
• 3187-83-5 rac-trans-N,N'-bis(salicylidene)-1,2-cyclohexanediamine 
• 176776-60-6 2,2′-[(±)-1,2-cyclohexanediylbis[(E)-nitrilomethylidyne]]bisphenol 
• 109669-64-9 C₂₀H₁₈Cl₄N₂O₄ 

Relevant academic research and scientific papers

The stereospecific addition of hydroxylamines to α,β-unsaturated sulfones, nitriles and nitro compounds

N-Alkyl hydroxylamines have been shown to undergo a highly stereospecific cis addition to α,β-unsaturated sulfones, nitriles and nitro compounds.

Method for synthesizing trans-cyclohexyldiamine

The invention discloses a method for synthesizing trans-cyclohexyldiamine. The method comprises the following steps: by using epoxy cyclohexane as the raw material, carrying out ring opening with ammonia water, adding sulfuric acid for dewatering and salification, adding free alkali, carrying out ring opening with ammonia water, and distilling to obtain the trans-cyclohexyldiamine. The method has the advantages of high repetitiveness of the synthesis route, and simple and accessible raw materials, and provides an alternative scheme for obtaining the trans-cyclohexyldiamine pure product.

A diamine-exchange reaction of dihydropyrazines

Dihydropyrazines reacted with 1,2-diamines to form tetraazadecalins as intermediates, and then the reaction proceeded forward to dissociate into alternate dihydropyrazine and diamine, or backward to dissociate into the starting materials in certain equilibrium. The product distribution is controlled by diamine-exchange equilibrium reaction. The various equilibrium reactions were analyzed by NMR spectroscopy.

Diastereo- and enantioselective synthesis of vicinal diamines via aza-Michael addition to nitroalkenes

The asymmetric synthesis of protected 1,2-diamines 4 by aza-analogous Michael addition of (-)-(2S,3R,4R,5S)-1-amino-3,4-dimethoxy-2,5-bis(methoxymethyl)pyrrolid ine (ADMP) to nitroalkenes 1 in good overall yields and high enantiomeric excesses (ee = 93-96%) is described. The auxiliary constitutes a novel chiral equivalent of ammonia and is removed under reductive N-N bond cleavage with Raney nickel, which also reduces the nitro group. The absolute configuration was determined by NMR-spectroscopic methods and polarimetry.