41016-29-9

Upstream product

• 71018-31-0 2-methyl-3-phenyl-succinic acid-anhydride 
• 168475-91-0 6a-Phenyl-3a,6a-dihydro-3H-furo[3,4-c]pyrazole-4,6-dione 
• 408306-86-5 3-cyano-2-hydroxy-2-methyl-3-phenyl-propionic acid 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 616-02-4 citraconic acid anhydride 
• 36122-35-7 2-phenylmaleic anhydride 
• 673-32-5 1-Phenylprop-1-yne 
• 124-38-9 carbon dioxide 
• 536-74-3 phenylacetylene 
• 103-82-2 phenylacetic acid 
• 113-24-6 sodium pyruvate 
• 858805-59-1 2-hydroxy-2-methyl-3-phenyl-succinamic acid 
• 635-51-8 2-phenylsuccinic acid 

Downstream Products

• 110937-05-8 Methyl-phenyl-fumarsaeure 
• 125294-37-3 α-(2-methyl-2,3-dihydro-3-oxo-1,4-benzothiazin-2-yl)phenylacetic acid 
• 189300-17-2 N-benzyl-3-methyl-4-phenylmaleimide 
• 357607-22-8 1-benzyl-3-phenyl-4-methyl-5-(2-chloroethoxy)-(2,5)-dihydro-2-pyrrolone 
• 1012334-92-7 3-(bromomethyl)-4-phenylfuran-2,5-dione 
• 1104516-50-8 4-methyl-3,5,6-triphenyl-2H-pyran-2-on 

Relevant academic research and scientific papers

Facile Synthesis of γ-Butenolides and Maleic Anhydrides via Annulation of α-Keto Acids and Triazenyl Alkynes

A facile synthesis of γ-butenolides and maleic anhydrides via annulation of α-keto acids and triazenyl alkynes is described. In this process, α-keto acids and triazenyl alkynes could undergo a self-catalyzed annulation at room temperature to deliver γ-butenolides efficiently, while the further addition of BF3-Et2O furnished maleic anhydrides. Overall, these processes have mild reaction conditions, broad scope, and high efficiency.

Facile Synthesis of 3-N-Alkyl Pyrimidin-2,4-diones from N-Sulfonyloxy Maleimides and Amines

Reaction of variously substituted N-trifluoromethanesulfonyloxy maleimides with primary amines in the presence of potassium carbonate in DMF at room temperature results in the formation of 3-N-alkyl pyrimidin-2,4-diones in good yield.

Synthesis of gymnoascolide A

Recently isolated 4-benzyl-3-phenylfuran-2,5-dione and antifungal gymnoascolide A have been synthesized using the chemoselective S N2′ coupling of phenylmagnesium bromide with dimethyl 2-(bromomethyl)fumarate, chemoselective allylic substitution of bromide in 3-(bromomethyl)-4-phenylfuran-2,5-dione with phenylmagnesium bromide and regioselective N-Selectride-induced reduction of 3-benzyl-4-phenylfuran-2,5- dione as the key reactions. Georg Thieme Verlag Stuttgart.

Efficient electrochemical dicarboxylations of arylacetylenes with carbon dioxide using nickel as the cathode

The electrochemical dicarboxylation of arylacetylenes with carbon dioxide could be smoothly achieved in an undivided cell using Ni as the cathode and Al as the anode with n-Bu4NBr-DMF as the supporting electrolyte, at a constant current under CO2 pressure of 3 MPa and room temperature in the absence of additional catalysts. The corresponding aryl-maleic anhydrides and 2-arylsuccinic acids were afforded in excellent total yields (82-94%). Under anhydrous conditions, an unsaturated aryl-maleic anhydride as the main product was obtained, while the presence of H2O would lead to the formation of saturated 2-arylsuccinic acids. The results of cyclic voltammetric experiments show that a nickel cathode itself plays the catalytic role in the reduction reaction of arylacetylenes with CO2.

A simple, convenient method for the synthesis of maleic anhydrides from α-keto esters and alkanoic acid anhydrides using the TiCl 4/n-Bu3N reagent system

Reaction of α-keto esters with alkanoic acid anhydrides using the TiCl4/n-Bu3N reagent system gives the corresponding maleic anhydrides in 62-95% yields.

Synthesis of N-substituted -alkoxy-3-aryl-4-methyl-2,5-dihydro-2-pyrrolones

5-Alkoxy-1-aralkyl-3-aryl-4-methyl-2,5-dihydro-2-pyrrolones and the corresponding alkylthio derivatives were synthesized for the first time through the intermediate formation of unsymmetrical maleimides. The possibility of wide variation of the substituen

Furan-2(3H)- and -2(5H)-ones. Part 6. Di-?-methane rearrangement of the α-substituted 4-benzylfuran-2(5H)-one system

The effect of the 'central methane' substitution on the di-?-methane rearrangement in 4-benzyl-2,5-dihydrofuran-2-ones 8a-d was investigated.Significant enhancement of efficiency in the rearrangement leading in high combined yields to two isomeric products, endo-12 and exo-12, is discussed in terms of both the substituent effects at the benzylic carbon and the restrained features of the ring-enrolled ?-system.The origin of the difference in chemoselectivity compared with that of the 3-benzyl counterpart 5 where a photoarylated product 6 resulted upon photoirradiation was also investigated, and was rationalized by postulating a higher reactivity at the β-position of the enone system.