4107-01-1

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Diphenyl-N-p-tolyl-acetamide is used as an intermediate in the synthesis of various drugs and pharmaceuticals for its role in creating compounds with therapeutic effects.
Used in Dye Industry:
2,2-DIPHENYL-N-P-TOLYL-ACETAMIDE is also utilized as an intermediate in the production of dyes, contributing to the coloration processes in different applications.
Used in Pain Management:
2,2-Diphenyl-N-p-tolyl-acetamide is used as an analgesic agent for its pain-relieving properties, helping to alleviate discomfort and reduce fever in patients.
Used in Inflammation Treatment:
Due to its anti-inflammatory characteristics, it is employed in the treatment of conditions marked by inflammation, aiming to reduce swelling and associated symptoms.

InChI:InChI=1/C21H19NO/c1-16-12-14-19(15-13-16)22-21(23)20(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-15,20H,1H3,(H,22,23)

Upstream product

• 64-17-5 ethanol 
• 5110-46-3 2-chloro-2,2-diphenyl-N-p-tolyl-acetimidoyl chloride 
• 106-49-0 p-toluidine 
• 79-11-8 chloroacetic acid 
• 5110-45-2 diphenylketene-N-p-tolylimine 
• 104-94-9 4-methoxy-aniline 
• 95460-01-8 N-Acetyldiphenylacetotoluidide 
• 64-19-7 acetic acid 
• 62-53-3 aniline 
• 91374-52-6 1-(2,2-diphenyl-1-chlorovinyl)-1-p-tolyl-2,2-dimethylurea 
• 75-98-9 Trimethylacetic acid 
• 117-34-0 2,2-diphenylacetic acid 
• 32177-09-6 chloro-diphenyl-acetic acid p-toluidide 
• 525-06-4 diphenyl ketene 

Downstream Products

• 26907-03-9 2-benzhydrylidene-5-methyl-3-p-tolyl-[1,3]oxazinane-4,6-dione 
• 74612-94-5 2-phenylthio-N-p-tolyl(diphenyl)acetamide 
• 74612-89-8 N-(1-chloro-2,2-diphenyl-2-phenylthioethylidene)-p-toluidine 
• 82833-67-8 N-(1-ethoxy-2,2-diphenyl-2-phenylthioethylidene)-p-toluidine 
• 119-61-9 benzophenone 
• 4695-13-0 2,2-diphenylacetamide 
• 117-34-0 2,2-diphenylacetic acid 
• 86-29-3 Diphenylacetonitrile 
• 5267-35-6 N-(diphenylmethyl)acetamide 
• 22800-71-1 N-(diphenylmethylene)acetamide 
• 1375263-32-3 1-acetyl-3,3-diphenylaziridin-2-one 
• 198337-87-0 C₂₀H₁₆FNO 
• 70481-06-0 N-<4-Brom-phenyl>-diphenylacetamid 
• 70298-77-0 N-(4-nitrophenyl)-2,2-di-phenylacetamide 

Relevant academic research and scientific papers

Electrochemical oxidation of amides of type Ph2CHCONHAr

Anodic oxidation of N-aryl-2,2-diphenylacetamides in acetonitrile undergoes three types of bond-cleavage, one between the benzylic carbon and the carbonyl group, the second between a carbonyl and 'N', and the third between the 'N' atom and aryl group. The selectivity of the cleavage and nature of emerged products is highly dependent on the nature of substituent attached to the aryl group. For example, electron-withdrawing groups direct the benzyl-carbonyl bond-breaking whereas electron-donating substituents favor the N-aryl bond cleavage. The type of products obtained involve benzophenone, 2,2-diphenylacetamide, N-(diphenylmethylene)acetamide, N-(diphenylmethyl)acetamide, α-lactam (1-acetyl-3,3-diphenylaziridin-2-one, as a 1:1 complex with 2,4-dinitroaniline) and aniline derivatives.

Site Selectivity in the Reaction of Formyl-2H-azirine-N-arylimines with Diphenylketene

2-Formyl-2H-azirine-N-arylimines 1a-c react with diphenylketene 2 to afford 2H-2-azirinyl-2-azetidinones 3a-c and N-aryldiphenylacetamides 4a-c by reaction at the exo-imino group.Derivatives containing the bulkier methyl group at the 2-position, 1d-f, produce only 4a-c.

ADDITION AT THE C=N BOND IN KETENE IMINES. REACTION OF DIPHENYLKETENE N-(p-TOLYL)IMINE WITH N,N-DIMETHYLDICHLOROMETHYLENEAMMONIUM CHLORIDE

Electrophilic addition to arylketene imines at the C=N bond is described for the reaction of diphenylketene N-(p-tolyl)imine with N,N-dimethyldichloromethyleneammonium chloride.Chlorinating characteristics were found in the complex of N,N-dimethyldichloromethyleneammonium chloride with chlorine.

REACTION OF DIPHENYLKETENE N-(p-TOLYL)IMINE WITH CARBOXYLIC ACIDS IN THE PRESENCE OF ARYLAMINES

The reaction of diphenylketene p-tolylimine with carboxylic acids in aprotic organic solvents is accelerated by primary arylamines.The reaction rate is described by overall kinetic equation including calalytic and noncatalytic path.Additions of pyridine greatly retard the reaction.The proposal according to which the catalytic reaction takes place through a cyclic transition state, formed from the ketene imine and the complex of the carboxylic acid with the amine, was substantiated.