41103-87-1

Basic information

• Product Name: 2-[(4-methylphenyl)sulfinyl]-1-phenylethanol
• CAS NO: 41103-87-1
• Molecular Formula: C₁₅H₁₆O₂S
• Molecular Weight: 260.3513
• Mol File: 41103-87-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 470.1°C at 760 mmHg
• Flash Point: 238.1°C
• Density: 1.25g/cm³
• Vapor Pressure: 1.21E-09mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 2-[(4-methylphenyl)sulfinyl]-1-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-methylphenyl)sulfinyl]-1-phenylethanol(41103-87-1)
• EPA Substance Registry System: 2-[(4-methylphenyl)sulfinyl]-1-phenylethanol(41103-87-1)

Safety Data

• Hazardous Substances Data: 41103-87-1(Hazardous Substances Data)

Usage

General Description

2-[(4-methylphenyl)sulfinyl]-1-phenylethanol, also known as modafinil, is a medication used to treat narcolepsy, shift work sleep disorder, and obstructive sleep apnea. It works by increasing wakefulness and decreasing excessive daytime sleepiness. Modafinil is a central nervous system stimulant that affects certain neurotransmitters in the brain, specifically dopamine, norepinephrine, and histamine. It is considered a Schedule IV controlled substance due to its potential for abuse and addiction. Common side effects of modafinil include headache, nausea, nervousness, and difficulty sleeping. It has a low risk of dependence compared to other stimulants, making it a popular option for treating sleep disorders.

Upstream product

• 17530-89-1 p-tolyl phenacyl sulphoxide 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 100-52-7 benzaldehyde 
• 52154-24-2 (R)-p-tolylsulfinylacetophenone 
• 934-72-5 Methyl p-tolyl sulfoxide 
• 61735-44-2 1-Chloro-1-phenyl-2-(toluenesulfinyl)ethan 
• 100-42-5 styrene 
• 106-45-6 para-thiocresol 

Downstream Products

• 52834-89-6 (2RS,3SR)-2-amino-3-methoxy-3-phenyl-propionic acid 
• 19190-53-5 2-methoxy-2-phenylacetaldehyde 
• 54755-88-3 S-(p-Tolyl)-2-acetoxy-2-phenylthioacetat 
• 54755-95-2 2-oxo-1-phenyl-2-(phenylamino)ethyl acetate 
• 54755-89-4 benzoyl(4-methylphenylthio)methyl acetate 
• 33046-45-6 1-phenyl-2-(p-tolylthio)ethanone 
• 4410-31-5 (RS)-mandelamide 
• 50911-27-8 carbamoyl(phenyl)methyl acetate 
• 20780-54-5 (S)-styrene oxide 
• 20780-53-4 (R)-Styrene oxide 
• 52948-88-6 1,2-Diacetoxy-2-phenylethyl-p-tolylsulfid 
• 42330-51-8 rac-(R)-1-phenyl-2-(p-tolylthio)ethan-1-ol 
• 17530-89-1 p-tolyl phenacyl sulphoxide 

Relevant articles and documents

Br?nsted acid-catalyzed chemodivergent reactions of: Ortho -mercaptobenzyl alcohols with 3-alkyl-2-vinylindoles and styrenes: [5+2] cyclization versus hydroxysulfenylation

Chemodivergent [5+2] cyclization and hydroxysulfenylation reactions of ortho-mercaptobenzyl alcohols with 3-alkyl-2-vinylindoles and styrenes were established in the presence of Br?nsted acid, which provide efficient methods for constructing benzoxathiepi

Solvent-enabled radical selectivities: Controlled syntheses of sulfoxides and sulfides

Controlling selectivity is of central importance to radical chemistry. However, the highly reactive and unstable radical intermediates make this task especially challenging. Herein, a strategy for taming radical redox reactions has been developed, in which solvent-bonding can alter the reactivity of the generated radical intermediates and thereby drastically alter the reaction selectivity at room temperature. Various β-oxy sulfoxides and β-hydroxy sulfides can be facilely obtained, some of which are difficult to synthesize by existing methods. Notably, neither a metal catalyst nor any further additives are necessary in these processes. Solvent selection alters the reactivity of the generated reaction intermediate and drastically switches the reaction selectivity under simple and mild conditions. Various β-oxy sulfoxides and β-hydroxy sulfides could be facilely obtained from readily available starting materials. Importantly, neither a metal catalyst nor an additional additive was necessary in these transformations.

A novel sulfinylation of alkenes by tosyl cyanide with titanium(IV) chloride

Tosyl cyanide is activated by titanium(IV) chloride to generate a tolylsulfinyl chloride equivalent, which readily stereo- and regio- specifically adds to certain alkenes to provide β-chlorosulfoxides. These chlorides rapidly hydrolyse on silica gel to provide β-hydroxysulfoxides in stereocontrolled manner.