413576-94-0Relevant academic research and scientific papers
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: Design, synthesis, DNA binding, and anticancer properties
Kupchinsky, Stanley,Centioni, Sara,Howard, Tiffany,Trzupek, John,Roller, Shane,Carnahan, Virginia,Townes, Heather,Purnell, Bethany,Price, Carly,Handl, Heather,Summerville, Kaitlin,Johnson, Kimberly,Toth, James,Hudson, Stephen,Kiakos, Konstantinos,Hartley, John A.,Lee, Moses
, p. 6221 - 6236 (2007/10/03)
The synthesis, DNA binding properties, and in vitro and in vivo anticancer activity of fifteen achiral seco-cyclopropylindoline (or achiral seco-CI) analogs (5a-o) of CC-1065 and the duocarmycins are described. The achiral seco-CI analogs contain a 4-hydr
Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins
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Page column 36, 37, (2010/02/05)
The present invention relates to novel achiral seco-analogues of DNA minor groove and sequence-selective alkylating agents (+)-CC1065 and the duocarmycins, depicted as general class I, II, III, IV and V: wherein X is a good leaving group, such as a chlori
Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins
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, (2008/06/13)
The present invention relates to novel achiral seco-analogues of the DNA minor groove and sequence-selective alkylating agents (+)-CC1065 and the duocarmycins, depicted as general class I, II III, IV and V: wherein X is a good leaving group, such as a chl
