41439-83-2

Upstream product

• 67-56-1 methanol 
• 63-84-3 dopa 

Downstream Products

• 90924-67-7 DL-dopachrome methyl ester 
• 5796-17-8 D-Dopa 
• 217975-69-4 3-(3.4-Bis-trifluoromethanesulfonyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 59686-54-3 methyl N-(tert-butyloxycarbonyl)-3,4-bis(hydroxy)phenylalanine carboxylate 
• 59-92-7 levodopa 
• 7101-51-1 L-DOPA methyl ester 
• 71855-43-1 (R)-(3,4-dihydroxyphenyl)alanine methyl ester 
• 663601-61-4 2-Amino-3-(3,4-dioxo-cyclohexa-1,5-dienyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Efficient and practical protection of the catechol residue of 3,4-dihydroxy-phenylalanine (DOPA) derivative as acetonide

The acetonide formation of 3,4-dihydroxyphenylalanine (DOPA) derivative was realized under efficient and practical reaction conditions: the reaction of the methyl ester of DOPA in acetone-i-PrOH in the presence of 5 mol% of TsOH afforded the catechol side chain protected DOPA as an acetonide in quantitative yield; the workup procedure is a simple evaporation of the solvents. This methodology allows an access to the reaction in large scale. Georg Thieme Verlag Stuttgart.

Synthesis of novel functionalised zinc phthalocyanines applicable in photodynamic therapy

The synthesis of several new phthalonitriles 3, 9, 14, 25, 33, and 36, functionalised with carboxyl groups, including two examples of amino acid derivatives is described. All new phthalonitriles were converted into their corresponding phthalocyaninatozinc compounds. The phthalocyanines, 2,3,9,10,16,17,23,24-octa(1-carboxyethyloxy)phthalocyaninatozinc (5), 2,9,16,23-tetra(2-amino-2-carboxyethyl)phthalocyaninatozinc (11), 2,9,16,23- tetra(1-carboxy-2-hydroxyethylaminocarbonyl)phthalocyaninatozinc (16), 1,8,15,22-tetra(carboxybutyl)phthalocyaninatozinc (27), 2,3,9,10,16,17,23,24- octa(carboxyalkyl)phthalocyaninatozinc (39), and the nonidentically substituted 9,10,16,17,23,24-hexa(carboxyalkyl)-2-[4-(N- succinimidyloxycarbonyl)butyl]phthaloyaninatozinc (41) are all sufficiently soluble in water. The nonidentically-substituted compounds are important due to their selective binding to tumor-selective antibodies. UV/Vis-spectroscopy was used to investigate the effect of more or less sterically-demanding substituents in the periphery of the phthalocyanines towards aggregation. The phototoxicity towards cancer cells of some of the new compounds was investigated in several in-vitro experiments.

Novel, transient pro-drug forms of L-DOPA

There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: STR1 wherein n represents an integer of from 2 to 50 with respect to formula (V-A), and wherein n represents an integer of from 1 to 50 with respect to formula (V-B); R represents a hydrogen atom, an acyl group, STR2 --CO-pyridyl, or --CO--R3, wherein R3 is the residue of any N,N-C1 -C2 dialkylamino acid or a C4 -C6 cycloalkylamino acid; R1 represents --OH, --O-lower alkyl, --O-benzyl, or a naturally occurring protein amino acid; and R2 represents STR3 --CO-pyridyl, a naturally occurring protein amino acid, 3',4'-L-diacyloxy phenylalanine, or --CO-R3. These compounds are all useful in the treatment of Parkinson's Disease.