4147-13-1

Usage

Type of compound

Synthetic estrogen hormone

Use

Typically used in hormone replacement therapy

Derivative of

Estradiol, a naturally occurring hormone produced in the ovaries

Treatment of symptoms

Menopause symptoms such as hot flashes, vaginal dryness, and mood swings

Additional use

Prescribed to prevent osteoporosis in postmenopausal women

Modification

Dibenzoate ester, which increases the stability and duration of action of the hormone in the body

Side effects

Can have various side effects

Usage guidance

Should be used under the guidance of a healthcare professional

Upstream product

• 50-28-2 estradiol 
• 98-88-4 benzoyl chloride 
• 36967-85-8 benzoyl triflate 
• 846-48-0 1-dehydrotestosterone 
• 53-16-7 Estrone 

Downstream Products

• 983-30-2 Estradiol-17beta-benzoate 

Relevant academic research and scientific papers

Benzoyl Trifluoromethanesulfonate. A Mild Reagent for the Benzoylation of Sterically Hindered Hydroxyls

Benzoyl trifluoromethanesulfonate (BzOTf) is a highly efficient reagent for the benzoylation of a variety of alcohols under mild conditions.These include hindered secondary and tertiary hydroxyls, phenols, and α-glycols.Sensitive functionality is stable when the reaction is performed in the presence of pyridine.Several unique rearrangements of Lewis acidsensitive compounds were also effected.

Benzoyl Trifluoromethanesulphonate. A Highly Efficient Benzoylating Agent for Sterically Hindered Hydroxyl Groups

Reactions of benzoyl trifluoromethanesulphonate (BzOTf) with a variety of alcohols, including some with sterically hindered secondary and tertiary hydroxy groups, with phenolic compounds, and with 1,2-diols at low temperatures provide the corresponding benzoates in high yield.