41526-73-2

Upstream product

• 36330-85-5 3-(p-phenyl)benzoylpropionic acid 
• 6057-60-9 4-(4-phenylphenyl)butanoic acid 
• 144464-65-3 7-Trifluoromethanesulphonyloxy-1,2,3,4-tetrahydronaphthalen-1-one 
• 98-80-6 phenylboronic acid 
• 865285-22-9 tri-isopropylsilyl 3,4,4a,5,6,7-hexahydro-1-naphthalenyl ether 
• 108-86-1 bromobenzene 
• 24037-79-4 bicyclo<4.4.0>dec-10-en-2-one 
• 930-68-7 cyclohexenone 
• 75506-74-0 3-<3-(1,3-dioxolan-2-yl)propyl>cyclohexanone 
• 92-52-4 biphenyl 
• 64959-04-2 7-cyclohexyl-3,4-dihydro-1(2H)-naphthalenone 

Downstream Products

• 95625-58-4 1,7-Diphenyl-1-hydroxy-1,2,3,4-tetrahydro-naphthalin 
• 137847-76-8 ethyl (Z)-(1,2,3,4-tetrahydro-7-phenyl-1-naphthylidene)acetate 
• 137847-75-7 ethyl (E)-(1,2,3,4-tetrahydro-7-phenyl-1-naphthylidene)acetate 
• 88064-99-7 2-t-butyl-5,6-dihydro-4,9-diphenylbenzochromelium trifluoromethanesulphonate 
• 88065-09-2 5,6,8,9-tetrahydro-2,7,12-triphenyldibenzoxanthylium trifluoromethanesulphonate 
• 88064-97-5 5,6-dihydro-2,4,9-triphenylbenzochromelium trifluoromethanesulphonate 
• 973-09-1 1-(o-Tolyl)-7-phenyl-3,4-dihydro-naphthalin 
• 58472-41-6 2-hydroxy-7-phenyl-1,4-naphthoquinone 
• 175394-16-8 methyl 7-phenyl-1-tetralone-2-carboxylate 
• 88065-01-4 2-t-butyl-5,6-dihydro-4,9-diphenylbenzoquinoline 
• 88065-00-3 5,6-dihydro-2,4,9-triphenylbenzoquinoline 
• 88065-10-5 5,6,8,9-tetrahydro-2,7,12-triphenyldibenzoacridine 
• 88065-05-8 1-n-butyl-5,6-dihydro-2,4,9-triphenylbenzoquinolinium trifluoromethanesulphonate 
• 88065-03-6 1-benzyl-5,6-dihydro-2,4,9-triphenylbenzoquinolinium trifluoromethanesulphonate 

Relevant academic research and scientific papers

Visible-light-induced oxidation/[3 + 2] cycloaddition/oxidative aromatization to construct benzo[ a]carbazoles from 1,2,3,4-tetrahydronaphthalene and arylhydrazine hydrochlorides

An efficient synthesis of benzo[a]carbazoles via visible-light-induced tandem oxidation/[3 + 2] cycloaddition/oxidative aromatization reactions was reported. The benzylic C(sp3)-H of tetrahydronaphthalene was activated through visible-light photoredox catalyst with oxygen as the clean oxidant under mild reaction conditions. This protocol proceeds efficiently with broad substrate scope, and the mechanism study was performed.

Intramolecular Büchner reaction and oxidative aromatization with SeO2 or O2

Intramolecular Büchner reaction of 1-diazo-5-phenylpentan-2-ones followed by oxidation with SeO2 or O2 in the presence of silica gel regioselectively gave 8-formyl-1-tetralones or one-carbon-lacking 1-tetralones, respectively.

HISTONE DEMETHYLASE INHIBITORS

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

A novel palladium-catalyzed arylation - dehydroaromatization reaction: Synthesis of 7-aryltetralones

(Chemical Equation Presented) A new one-pot room-temperature palladium-catalyzed synthesis of 7-aryltetralones was discovered. This tandem process includes a palladium-catalyzed γ-selective arylation of the enone 4 followed by a dehydrogenation-aromatization of the initial cross-coupling product.

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

The search for new small-molecule CCR5 antagonists by high-throughput screening (HTS) of the Takeda chemical library using [125I]RANTES and CHO/CCR5 cells led to the discovery of lead compounds (A, B) with a quaternary ammonium or phosphonium m

Phosphonic acid compounds, their production and use

The present invention relates to a compound of the general formula (I): STR1 wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q1 is a group of the formula --X--P(O)(OR1)(OR2) wherein X is a bond or a divalent group; R1 and R2, identical or different, are hydrogen or a lower alkyl, or may be combined together to form a ring; Q2 is hydrogen, a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; and the group of the formula --CON(Q1)(Q2) is connected to the a- or b-position carbon atom, or a salt thereof, which is useful as prophylactic and therapeutic agents of various metabolic bone diseases such as osteoporosis.

AMINO ACID DERIVATIVE

The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibition activity.This amino acid derivative is represented by the following general formula (I): STR1 wherein R 1 represents a hydrogen atom or an acyl group; R 2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an ary group which may have a substituent, a heteroaryl group which may have a substituent, an arylalkyl group which may have a substituent or a heteroarylalkyl group which may have a substituent;m and n represent each independently an integer of 0, 1 or 2 and J represents a cyclic group having an angiotensin I-converting enzyme inhibition activity.

2-Hydroxy-3-nitro-1,4-naphthoquinones

Substituted naphthoquinones of the formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2, R3 and R4 represent alkyl, aryl, alkoxy, hydroxy, hydrogen or halogen or any two of the groups R1, R2, R3 and R4 taken together complete a carbocyclic ring, have useful anti-allergy activity in mammals.

Synthesis and antiallergic activity of 2 hydroxy 3 nitro 1,4 naphthoquinones

A selection of novel 2-hydroxy-3-nitro-1,4-naphthoquinones are shown to be potent inhibitors of rat passive cutaneous anaphylaxis (PCA) and to have highest potency with alkyl substitution at both C-6 and C-7. The most potent compounds were 7c and 7e which produced a 50% inhibition in the rat PCA test at doses of about 10 μM/kg following subcutaneous administration and showed activity after oral administration. Related 4-hydroxy-3-nitro-2(1H)-naphthalenones had no effect on rat PCA in doses up to 500 μM/kg.