41589-61-1Relevant articles and documents
Influence of Microwaves on the Rate of Esterification of 2,4,6-Trimethylbenzoic Acid with 2-Propanol
Raner, Kevin D.,Strauss, Christopher R.
, p. 6231 - 6234 (1992)
The influence of microwave irradiation on the reaction kinetics of the acid-catalyzed esterification of 2,4,6-trimethylbenzoic acid in i-PrOH was investigated.The rate constants for the reaction at various temperatures were measured in experiments conduct
Scope and mechanistic insights into the use of tetradecyl(trihexyl) phosphonium bistriflimide: A remarkably selective ionic liquid solvent for substitution reactions
McNulty, James,Nair, Jerald J.,Cheekoori, Sreedhar,Larichev, Vladimir,Capretta, Alfredo,Robertson
, p. 9314 - 9322 (2007/10/03)
A survey of substitution reactions conducted in a phosphonium bistriflimide ionic liquid is presented. The results demonstrate high selectivity favoring substitution over typically competitive elimination and solvolytic processes even when challenging secondary and tertiary electrophiles are employed. The first reports of Kornblum substitution reactions in an ionic liquid are described that proceed with very high chemoselectivity in favor of nitro over nitroso products and elimi nation side products. The structure-reactivity study indicates that these reactions proceed through a narrow spectrum of pathways ranging from straight SN2 to a preassociation pathway along a saddle point that approaches the SN1 limit. The barrier to the formation of dissociated carbocations is attributed to the structural features of this ionic liquid that favor intervention of the associated nucleophile over dissociation, also preventing cross over to E1 processes. The lack of any basic entity in the phosphonium bistriflimide ionic liquid appears to prevent any potential base-mediated elimination reactions, which makes this a highly selective medium for use in general substitution reactions.
Efficient in situ esterification of carboxylic acids using cesium carbonate
Lee, Jong Chan,Oh, Yoon Seok,Cho, Sung Hye,Lee, Jung Il
, p. 480 - 483 (2007/10/03)
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