41654-12-0

Upstream product

• 802294-64-0 propionic acid 
• 98962-77-7 (3RS,4RS)-3,4-epoxy-3-methyl-valeric acid methyl ester 
• 186581-53-3 diazomethane 
• 89180-83-6 2,3-dibromo-2-methyl-butyryl chloride 
• 51302-90-0 Methyl 3-hydroxy-3-methylpentanoate 
• 710326-36-6 3,4-dibromo-3-methyl-2-pentanone 
• 124-41-4 sodium methylate 
• 86769-75-7 (3S,4R)-3-Methyl-4-phenylsulfanyl-pentanoic acid methyl ester 
• 91114-65-7 2,3-dibromo-2-methylbutanoic acid 
• 118660-64-3 (3RS,4SR)-4-chloro-3-hydroxy-3-methyl-valeric acid-lactone 
• 53496-45-0 4-hydroxy-3-methyl-pentan-2-one 
• 565-62-8 3-methylpent-3-en-2-one 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 

Downstream Products

• 41653-93-4 trans-Δ²-3-methylpentenoic acid 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

O-SILYLATED ENOLATES IN ORGANIC SYNTHESIS: SULPHUR-MEDIATED ALKYLATION OF ESTERS WITH ALKENES.

O-Silylated ester enolates can be alkylated, under ZnBr2-catalysis, by the PhSCl-adducts of mono- and di-substituted alkenes to give γ-phenylthioesters, from which sulphur can be removed both reductively and oxidatively.This alkene carbosulphenylation rea

Lithium/Ammonia Reductions of 2-Thiophenecarboxylic Acids

Lithium/ammonia reductions of 2-thiophenecarboxylic acids (1) in the absence of a proton source afforded mixtures of products.In the presence of methanol acyclic mercapto carboxylic acids (4) were the major products.Ring closure of 4 to the corresponding thiolactones (12) showed the double bonds in 4 to be of cis geometry.Attempts were made to prepare Z olefinic compounds derived from these mercapto carboxylic acids.Lithium 2-thiophenecarboxylate salts (2) afforded good yields of the corresponding 2,5-dihydro-2-thiophenecarboxylic acids (3).The presence of substituents on the ring and the ratio of metal to acid were significant factors in determining the nature of this products.A mechanism is proposed to explain the products observed.

Mevalonic acid analogs as inhibitors of cholesterol biosynthesis

A series of 20 mevalonic acid analogs were synthesized and tested for their ability to inhibit cholesterol biosynthesis from [2-14C]-mevalonate in rat liver homogenates. Removal of the 5-hydroxyl group from mevalonic acid produced an active inhibitor, 3-hydroxy-3-methylpentanoic acid. Removal of the 3-hydroxyl group, addition of an aromatic group in the 3-position, or insertion of a double bond reduced inhibitory activity. Compounds with an aromatic group or halide on the 5-position were active inhibitors. The most active inhibitor was 5-phenylpentanoic acid, with 50% inhibition at 0.064 mM.