41774-41-8Relevant academic research and scientific papers
BIOSYNTHESIS OF AXENOMYCIN D: INCORPORATION OF 13C-LABELLED PRECURSORS INTO THE MENADIONE CHROMOPHORE, DESOXYSUGARS AND THE AXENOLIDE
Friese, V.,Boos, A.,Bauch, H.-J.,Leistner, E.
, p. 613 - 622 (1993)
Experiments on the biosynthesis of the menadione chromophore of axenomycin D in Streptomyces lisandri resulted in the specific incorporation of label from L-methionine, propionate, propionate, propionate, glycerol and glucose.The data indicate that the menadione chromophore is derived from a metabolite of the shikimate pathway.The mode of incorporation shows, however, that the biosynthesis of the menadione chromophore of axenomycin differs from the biosynthesis of the menadione chromophore of menaquinones.Key Word Index: Streptomyces lisandri; axenomycin; biosynthesis; 13C-NMR spectroscopy.
Acetylation of aromatic compounds over H-BEA zeolite: The influence of the substituents on the reactivity and on the catalyst stability
Guidotti, Matteo,Canaff, Christine,Coustard, Jean-Marie,Magnoux, Patrick,Guisnet, Michel
, p. 375 - 383 (2007/10/03)
The acylation with acetic anhydride of six aromatic substrates with different features (degree of activation of the aromatic ring towards electrophilic substitution, number of rings, i.e., 1 or 2) was carried out in a batch reactor at 373 K over a H-BEA zeolite (Si/Al = 15) with nitrobenzene as a solvent. The acetylation rate was found to be very dependent on the degree of ring activation, with diffusion limitations playing only a limited role. The decrease of the rate with reaction time, which was very pronounced with poorly activated and deactivated substrates, is mainly due to the inhibiting effect of acetic acid and of the products of acetic anhydride condensation.
Naphthalene amides and sulphonamides, processes for their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
The invention relates to compounds of the general formula (I): STR1 wherein R3 represents a group STR2 R1, R2, R6, R7 being as defined in the description. Medicinal product useful in treating a disord
Synthesis, structure and pharmacological activity of acyl-2-naphthalene acetic acids and derivatives
Saint Martino Descours,Pacheco,Venco,Yavordios
, p. 5 - 9 (2007/10/02)
Acyl 2-naphthalene acetic derivatives are obtained by a Friedel and Crafts reaction from methyl 2-naphthalene acetate. Low polarity solvents permit selective acylation in the 5 and 8 position, polar solvents in position 6 and 7. The structure of these products is demonstrated by NMR spectra (250 MHz) studies. Unambiguous syntheses of several of them were performed. Acyl 2-naphthalene acetic derivatives show lower anti-inflammatory, analgesic and antipyretic activities in animals than their 1-naphthalene analogs.
