41891-17-2

Usage

Uses

Used in Chemical Reactions:
N-(Chloroformyl)butylamine is used as a reactive intermediate for facilitating acid reactions, where its chloroformyl group can participate in various chemical processes, contributing to the formation of new compounds.
Used in Laboratory Experimentation:
In the context of research and development, N-(Chloroformyl)butylamine serves as a valuable component in laboratory experiments, potentially aiding in the synthesis of complex organic molecules or the study of reaction mechanisms.
Used in Chemical Material Synthesis:
Its molecular structure suggests that N-(Chloroformyl)butylamine could be utilized in the synthesis of chemical materials, where its reactivity can be harnessed to create new products or improve existing ones.
Safety Precautions:
As with many industrial chemicals, it is crucial to exercise safety precautions when handling N-(Chloroformyl)butylamine. This includes avoiding inhalation and preventing contact with eyes, skin, and clothing to minimize health risks and ensure a safe working environment.

Upstream product

• 39078-72-3 S-methyl N-butylthiocarbamate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 109-73-9 N-butylamine 
• 75-44-5 phosgene 

Downstream Products

• 3149-00-6 phenbutamide 
• 552848-65-4 1-((2R,4aR,7R,8R,8aS)-6-Benzyloxy-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-3-butyl-urea 
• 339-43-5 carbutamide 
• 2224-10-4 Carboxytolbutamide 
• 30287-38-8 N-butyl-N'-(4-hydrazinocarbonyl-benzenesulfonyl)-urea 
• 4299-07-4 2-butyl-1,2-benzothiazolin-3-one 
• 4107-40-8 N-Butyl-N'-phenoxyharnstoff 
• 1427196-00-6 butyl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate 
• 1427195-96-7 butyl {4-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate 
• 54680-37-4 1-Butyl-1-nitroso-3-phenylharnstoff 
• 13738-74-4 3-(p-nitrobenzenesulfonyl)-1-butylurea 
• 24535-66-8 N-butyl-N'-(o-tolylsulfonyl)urea 
• 22486-31-3 Butyl-carbamic acid 4-[(4-ethoxy-phenylaminooxalyl)-amino]-phenyl ester 
• 67205-43-0 Butyl-carbamic acid 2,3,5-trichloro-4,6-dicyano-phenyl ester 

Relevant academic research and scientific papers

ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY DISEASES AND DISORDERS

The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.

COMPOUNDS, COMPOSITIONS AND METHODS FOR INCREASING CFTR ACTIVITY

The present disclosure features compounds such as those having the Formulae (Ila), (lIb), (lIc), (Ild), (IlIa), and (Illb), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (Ila), (lIb), (lIc), (lId), (IlIa), or (Illb).

COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY

The present disclosure features disclosed compounds which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound.

One-pot, three-step preparation of alkyl and aryl alkylcarbamates from S-methyl N-alkylthiocarbamates

A general procedure for the synthesis of alkyl and aryl alkylcarbamates starting from the corresponding 5-methyl N-alkylthiocarbamates is described. This procedure consists of three steps that are carried out in a one-pot fashion, without isolating the intermediate N-alkylcarbamoyl chlorides or alkyl isocyanates. All the target products were obtained in high yields (16 examples, average yield 91%). To be noted is the recovery of a co-product of industrial interest, dimethyl disulfide, in a half mole amount for each mole of thiocarbamate, with complete exploitation of the reagent. The alkyl isocyanates, if required, can also be isolated in high yields. Georg Thieme Verlag Stuttgart.

4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives

The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.