42117-32-8

Upstream product

• 25680-86-8 1,4-dimethoxybutan-2-one 
• 78-84-2 isobutyraldehyde 
• 67-56-1 methanol 
• 1074-26-6 4,4-dimethyl-2,3-epoxycyclohexanone 
• 1073-13-8 4,4-dimethylcyclohexenone 
• 43042-58-6 1-methoxybut-3-en-2-one 
• 2403-57-8 1-(2-methylprop-1-en-1-yl)pyrrolidine 

Downstream Products

• 64416-18-8 2-Methoxy-4.4-dimethylcyclohexanon 
• 42117-30-6 2-methoxy-4,4-dimethylcyclohexa-2,5-dien-1-one 
• 85312-31-8 bis<6-(2-methoxy-4,4-dimethyl-2,5-cyclohexadienone)selenide> 
• 82700-65-0 2-methoxy-6-hydroxy-4,4-dimethylcyclohexa-2,5-diene-1-one 
• 82700-69-4 6-Hydroxy-3-methoxy-5,5-dimethyl-5,6-dihydro-pyran-2-one 
• 85312-29-4 2-methoxy-5,5-dimethylcyclohex-2-en-1-one 
• 42747-41-1 trimethyl-2,5,5-cyclohexene-2-one-1 
• 802541-50-0 ethyl (3-methoxy-5,5-dimethyl-2-oxocyclohex-3-en-1-yl)(oxo)acetate 
• 1008520-70-4 2-Bromo-4-(3-methoxy-5,5-dimethyl-2-oxo-cyclohex-3-enecarbonyl)-benzonitrile 
• 191480-97-4 3-Hydroxy-1,1-dimethyl-cyclohexen-⁽²⁾-on-⁽⁴⁾ 
• 1008520-02-2 2-(Tetrahydro-pyran-4-ylamino)-4-(1,5,5-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-benzamide 
• 1008520-00-0 2-(Tetrahydro-pyran-4-ylamino)-4-(1,5,5-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-benzonitrile 
• 64416-06-4 2-Methoxy-4,4-dimethylmethylencyclohexan 
• 82700-85-4 2-ethoxy-4,4-dimethylcyclohex-2-en-1-one 

Relevant academic research and scientific papers

CXCR2 ANTAGONIST

A compound as a CXCR2 antagonist and an application thereof in preparing a drug as a CXCR2 antagonist. In particular, the present invention relates to a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

Hypervalent-Iodine-Mediated Formation of Epoxides from Carbon(sp2)-Carbon(sp3) Single Bonds

We have developed an efficient method for direct formation of epoxide groups from carbon(sp2)-carbon(sp3) single bonds of β-keto esters; the reaction is mediated by the water-soluble hypervalent iodine(V) reagent AIBX (5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ5-benzo[d][1,2]iodoxol-1-ol anion). On the basis of the results of density functional theory calculations and experimental studies, we propose that the reaction proceeds by a two-stage mechanism involving dehydrogenation of the β-keto ester substrates and epoxidation of the resulting enone intermediates. The rate-limiting step is abstraction of the β′-C-H (calculated free energy of activation, 24.5 kcal/mol).

Benzene, Pyridine, and Pyridazine Derivatives

Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R31, and R41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and

PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

Chemistry of 2-Methoxy-2,5-cyclohexadienones. I. Photochemistry of 2-Methoxy-4,4-dimethyl-2,5-cyclohexadienone

The title compound, 2-methoxy-4,4-dimethyl-2,5-cyclohexadienone (V), was prepared from 2-methoxy-4,4-dimethyl-2-cyclohexenone (VIa).A methanolic solution of V was irradiated with a 200 W mercury lamp at -3 deg C to give 2,2-dimethoxy-6,6-dimethylbicyclo3