42182-25-2

Usage

Uses

Used in Pharmaceutical Drug Development:
1-(2-Amino-pyridin-4-yl)-ethanone is used as a key intermediate in the synthesis of pharmaceutical drugs due to its ability to inhibit various enzymes and receptors. Its unique structure allows for the development of novel compounds with potential therapeutic effects.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2-Amino-pyridin-4-yl)-ethanone is used as a building block for the creation of more complex organic molecules. Its presence of both an amino and a ketone group makes it a versatile component in the synthesis of a wide range of compounds.
Used in Medicinal Chemistry Research:
1-(2-Amino-pyridin-4-yl)-ethanone is utilized as a research tool in medicinal chemistry to explore its potential role in the treatment of various diseases. Its biological activities have been studied extensively, with a focus on its potential use in the development of treatments for cancer and neurological disorders.
Used in Enzyme and Receptor Inhibition:
1-(2-Amino-pyridin-4-yl)-ethanone is employed as an inhibitor in biochemical research, targeting specific enzymes and receptors that are implicated in various pathological conditions. Its ability to modulate these biological targets makes it a promising candidate for the development of targeted therapies.
Overall, 1-(2-Amino-pyridin-4-yl)-ethanone is a multifaceted chemical compound with a broad spectrum of applications in the pharmaceutical and chemical industries, making it an essential component in the ongoing pursuit of new and effective treatments for a variety of diseases.

Upstream product

• 80882-44-6 1-(2-amino-4-pyridyl)-1-ethylenedioxyethane 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 67-63-0 isopropyl alcohol 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 
• 42182-27-4 4-cyanopyridin-2-amine 
• 80882-43-5 1-(2-hydrazino-4-pyridyl)-1-ethylenedioxyethane 
• 80882-42-4 4-acetyl-2-chloropyridine ethylene glycol ketal 
• 23794-15-2 1-(2-chloropyridin-4-yl)ethan-1-one 

Downstream Products

• 885266-91-1 1-(2-aminopyridin-4-yl)ethanol 
• 1229649-40-4 N-(4-(1-((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)ethyl)pyridin-2-yl)-2-methoxyacetamide 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a defined subset of kinase enzymes modulating inflammatory processes that would be effective against steroid refractory disease and exhibit a sustained duration of action after inhaled delivery.

Inhibitors of Hemopoietic Cell Kinase (P59-HCK) and Their Use in the Treatment of Influenza Infection

The present invention relates inter alia to the treatment or prevention of influenza virus infection (including subtypes influenza A virus, influenza B virus, avian strain H5N1, A/H1N1, H3N2 and/or pandemic influenza) using compounds which inhibit the act

INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION

The present invention relates inter alia to the treatment or prevention of influenza virus infection (including subtypes influenza A virus, influenza B virus, avian strain H5N1, A/H1N1, H3N2 and/or pandemic influenza) using compounds which inhibit the activity of p59-HCK and to a method of screening for a candidate drug substance intended to prevent or treat influenza virus infection in a subject, said method comprising identifying a test substance capable of inhibiting p59-HCK activity.

2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS

Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

The synthesis of 2-amino-4-(4-imidazolyl)pyridines

A general synthetic scheme for the preparation of 2-amino-4-(4-imidazolyl)pyridines, potential histamine H2 antagonists, is described. The synthesis is based on the Neber rearrangement of 1-(4-pyridyl)-l-alkanone oxime O-tosylates to the appropriate α-aminoketones or α-aminoketals, which are then converted to the corresponding imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of chloride by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates.