42606-39-3

Basic information

• Product Name: 8-Nitroquinolin-5-amine
• Synonyms: 8-Nitroquinolin-5-amine
• CAS NO: 42606-39-3
• Molecular Formula: C₉H₇N₃O₂
• Molecular Weight: 189.17
• Mol File: 42606-39-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 280 °C
• Boiling Point: 439.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.445±0.06 g/cm3(Predicted)
• PKA: 1.77±0.29(Predicted)
• CAS DataBase Reference: 8-Nitroquinolin-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Nitroquinolin-5-amine(42606-39-3)
• EPA Substance Registry System: 8-Nitroquinolin-5-amine(42606-39-3)

Safety Data

• Hazardous Substances Data: 42606-39-3(Hazardous Substances Data)

Upstream product

• 607-35-2 8-nitroquinoline 
• 7732-18-5 water 
• 7664-41-7 ammonia 
• 7664-93-9 sulfuric acid 
• 6942-98-9 5-chloro-8-nitroquinoline 
• 67-56-1 methanol 
• 74-89-5 methylamine 

Downstream Products

• 835898-99-2 5-hydroxy-6-p-tolylsulfonyl-8-p-tolylsulfonylaminoquinoline 
• 1338952-12-7 8-chloro-5-hydrazinoquinoline hydrochloride 
• 1338952-14-9 5-hydrazino-8-nitroquinoline hydrochloride 
• 611-33-6 8-chloroquinoline 

Relevant articles and documents

Synthesis and Antiproliferative Activity of Some Ellipticine-Like 11H-Pyrido[a]carbazole Derivatives

Some modified 11H-pyrido[a]carbazoles (11H-PyC) and their corresponding tetrahydro derivatives (11H-THPyC) were prepared. A common multistep pathway characterized by conventional reactions, including a Fischer-indole-type synthesis, yielded the tetracycli

Vicarious nucleophilic amination of Nitroquinolines with 4-amino-1,2,4-triazole

3-, 5-. 6-, 7- and 8-Nitroquinolines react with 4-amino-l,2,4-triazole in basic medium (potassium tert-butoxide-dimethyl sulfoxide) giving amino products of the vicarious nucleophilic substitution (VNS) of hydrogen, predominantly at ortho position to the nitro group, except 8-nitroquinoline, which reacts at para position. Additionally, furazano[3,4-f]- and furazano[3,4-zh]quinoline were obtained in the case of 5- and 8- nitroquinoline, respectively. 2-Nitroquinoline was aminated to 2-quinolino(l,2,4-triazol-4-yl)amine in these conditions.

Oxidative Methylamination of Nitroquinolines

3-, 5-, 6-, 7- and 8-nitroquinoline as well as 5,7- and 6,8-dinitroquinoline are methylaminated with a liquid methylamine solution of potassium permanganate (LMA/PP) to the corresponding mono- and bis(methylamino)-substituted compounds. 2-Nitroquinoline is aminated with LMA/PP to 2-(methylamino)quinoline.The intermediate methylamino ?-adducts of 3-nitro- and 5,7- and 6,8-dinitroquinoline are detected by 1H-NMR spectroscopy.Quantum chemical calculations for the mononitroquinolines suggest that the experimentally observed regioselectivity of the methylamination is controlled by an interaction of frontal molecular orbitals (FMO) of the reagents. Key Words: Methylaminations / ?-Adducts, methylamino / Calculations, FMO / Quinolines / Aminations