42797-18-2

Basic information

• Product Name: o-(4-Biphenylylcarbonyl)benzoic acid
• Synonyms: o-(4-Biphenylylcarbonyl)benzoic acid;o-(1,1'-Biphenyl-4-ylcarbonyl)benzoic acid;2-(4-Biphenylylcarbonyl)benzoic acid;2-(4-Phenylbenzoyl)benzoic acid;2-[(4-phenylphenyl)carbonyl]benzoic acid;o-(4-Biphenylylcarbonyl)
• CAS NO: 42797-18-2
• Molecular Formula: C₂₀H₁₄O₃
• Molecular Weight: 302.33
• EINECS: 200-258-5
• Mol File: 42797-18-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 225-227℃
• Boiling Point: 539.3 °C at 760 mmHg
• Flash Point: 294.1 °C
• Appearance: /
• Density: 1.232
• Vapor Pressure: 1.83E-12mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.34±0.36(Predicted)
• CAS DataBase Reference: o-(4-Biphenylylcarbonyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: o-(4-Biphenylylcarbonyl)benzoic acid(42797-18-2)
• EPA Substance Registry System: o-(4-Biphenylylcarbonyl)benzoic acid(42797-18-2)

Safety Data

• RTECS: DG4375000
• Hazardous Substances Data: 42797-18-2(Hazardous Substances Data)

Usage

General Description

"O-(4-Biphenylylcarbonyl)benzoic acid, also known as biphenyl-4-yl-carbonyl-benzoic acid, is a synthetic, aromatic compound, with a molecular formula C20H14O3. It remains stable under normal temperatures and pressures. However, it may release toxic fumes when exposed to high temperatures or upon decomposing. The chemical is generally used for research purposes, specifically in organic and medicinal chemistry. As with other chemicals, its inappropriate handling or prolonged exposure may cause skin, eye, and respiratory tract irritation. Therefore, safety measures should be taken while handling it, such as wearing suitable protective clothing and eye/face protection.

InChI:InChI=1/C20H14O3/c21-19(17-8-4-5-9-18(17)20(22)23)16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,22,23)

Upstream product

• 85-44-9 phthalic anhydride 
• 7446-70-0 aluminium trichloride 
• 92-52-4 biphenyl 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 15726-11-1 cis-2-Chlor-3-(p-biphenylyl)-3-phenylacrylsaeure 
• 19772-69-1 2-Chlor-3-<4-biphenylyl>-indenon-(1) 

Downstream Products

• 6485-97-8 2-Phenyl-anthrachinon 
• 159451-74-8 2N-acetyl-4-biphenyl-1(2H) phthalazinone 
• 77308-54-4 2-([1,1'-biphenyl]-4-ylmethyl)benzoic acid 
• 1981-38-0 2-phenylanthracene 
• 1714-13-2 2-phenyl-anthrone 
• 1589553-81-0 2-phenyl-9,10-bis(4-n-hexylphenyl)anthracene 
• 1276024-22-6 2-(1H-benzo[d]imidazol-5-yl)-3-(4-biphenyl)isoindolin-1-one 
• 77308-55-5 C₂₈H₂₀O₅ 
• 77308-56-6 di(o-carboxybenzyl)4,4' biphenyle 

Relevant articles and documents

SYNTHESIS OF β-PHENYLANTHRAQUINONE BY THERMAL INTRAMOLECULAR DEHYDROGENATION OF p-(3-CHLORO-3-PHTHALIDYL)DIPHENYL

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A facile greener synthesis, antimicrobial evaluation and molecular modelling of new 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-one derivatives

Abstract: The synthesis of 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-ones was performed by cyclization of 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine with 2-aroylbenzoic acids in ethanol containing a catalytic amount of concentrated sulfuric acid under solid state conditions. All these synthesized compounds (8a–h) were screened for their in vitro antibacterial activity against gram-positive bacteria such as (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli) and also evaluated for their antifungal activity against Aspergillus Niger and Helmenthosphorium oryzae fungal strains. Some of the products demonstrate good antibacterial activity and moderate antifungal activity. In predominantly, 8b, 8d, 8g, and 8h compounds showed good to excellent antibacterial and antifungal activities. The antimicrobial activity of the compound 8 was further investigated with the help of in LibDock score docking study to predict the active sites. Graphical abstract: [Figure not available: see fulltext.].

Synthesis and Biological Evaluation of New Phthalazinone Derivatives as Anti-Inflammatory and Anti-Proliferative Agents

The chemistry of phthalazine derivatives has been of increasing interest since many of these compounds have found many chemotherapeutic applications. So this study aims to synthesize a library of phthalazine derivatives and to investigate their anti-inflammatory and anti-proliferative activities. Sixteen new phthalazinone derivatives (2a-p) were synthesized and tested for their in vitro antiproliferative and in vivo anti-inflammatory activities. All the synthesized compounds were identified and characterized by IR, 1H NMR, 13C NMR spectroscopy, and MS. Two compounds, 2b and 2i, showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib in the carrageenan-induced rat paw edema model at 3 and 5 h, respectively. Three compounds (2h, 2j, and 2g) showed moderate sensitivity toward the renal cancer cell line UO-31. A library of new phthalazone compounds (2a-p) was synthesized as dual inhibitors (COX-2/LOX-5) and evaluated for their anti-inflammatory, anticancer activities. Two compounds showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib, whereas three compounds showed moderate sensitivity toward the renal cancer cell line UO-31.