42832-36-0Relevant academic research and scientific papers
Electrodimerization ofN-Alkoxyamides for the Synthesis of Hydrazines
Nasier, Abudulajiang,Chang, Xihao,Guo, Chang
, p. 16068 - 16076 (2021/09/18)
An efficient and valuable N-N dimerization reaction ofN-alkoxyamides is reported under undivided electrolytic conditions. This electrochemical strategy provides a powerful way to access a wide range of advanced, highly functionalized hydrazines. Remarkably, anN-centered radical generated from the cleavage of the N-H bond under electrolytic conditions plays a crucial role in this transformation. Furthermore, variousN-alkoxyamides bearing different substituents are suitable in this transformation, furnishing the corresponding hydrazines in up to 92% yield.
Syntheses and evaluation of substituted aromatic hydroxamates and hydroxamic acids that target Mycobacterium tuberculosis
Majewski, Mark W.,Cho, Sanghyun,Miller, Patricia A.,Franzblau, Scott G.,Miller, Marvin J.
supporting information, p. 4933 - 4936 (2015/10/28)
Tuberculosis (TB) continues to remain one of the most threatening diseases in the world. With the emergence of multi-drug resistant (MDR) and extensively drug resistant (XDR) strains, the need to develop new therapies is dire. The syntheses of a focused library of hydroxamates and hydroxamic acids is described, as well as anti-TB activity in the microplate alamar blue assay (MABA). A number of compounds exhibited good activity against Mtb, with notable compounds exhibiting MIC values in the range of 20-0.71 μM. This work suggests that both hydroxamates and their free acids may be incorporated into more complex scaffolds and serve as potential leads for the development of anti-TB agents.
Copper-catalyzed cross-coupling of O -alkyl hydroxamates with aryl iodides
Kukosha, Tatyana,Trufilkina, Nadezhda,Belyakov, Sergey,Katkevics, Martins
supporting information; experimental part, p. 2413 - 2423 (2012/09/07)
N-Aryl-O-alkylhydroxamic acid derivatives were prepared by copper-catalyzed cross-coupling of hydroxamates with aryl iodides. The reaction conditions are compatible with standard hydroxy-protecting groups on the hydroxylamine moiety and are applicable to
N-[(diphenoxyphosphoryl)oxy]-2-phenyl-1H-benzimidazole as a versatile reagent for synthesis O-alkylhydroxamic acids
Kokare, Nagnnath D.,Shinde, Devanand B.
, p. 981 - 986 (2008/09/21)
(Chemical Equation Presented) Highly efficient reagent, N-[(diphenoxyphosphoryl)oxy]-2-phenyl-1H-benzimidazole was synthesized and its applicability was demonstrated for the synthesis of O-alkyl hydroxamic acids. The efficiency of the reagent was evaluate
Reactions of N-Acyl-O-arylhydroxylamines: Part IV - Preparation of Some N-Arylsulphonyl-O-arylhydroxylamines
Singha, A. S.,Misra, B. N.
, p. 361 - 363 (2007/10/02)
A number of N-arylsulphonyl-O-alkylhydroxylamines (III) have been prepared by condensing appropriate alkoxyamines with arylsulphonyl chlorides in the presence of a base.The alkoxyamines have been obtained from the corresponding alkoxyamine hydrochlorides or hydrobromides (II) which in turn have been prepared by the hydrolysis of appropriate N-benzoyl-O-alkylhydroxylamines (I) with ethanolic hydrogen chloride or hydrogen bromide.The structure assignments of III are based on elemental analyses, chemical reaction and spectral (IR, PMR) data.
