4293-52-1

Basic information

• Product Name: N-(1-hydroxybutan-2-yl)acetamide
• CAS NO: 4293-52-1
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.1729
• Mol File: 4293-52-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 305.5°C at 760 mmHg
• Flash Point: 138.5°C
• Density: 0.998g/cm³
• Vapor Pressure: 7.72E-05mmHg at 25°C
• Refractive Index: 1.444
• CAS DataBase Reference: N-(1-hydroxybutan-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-hydroxybutan-2-yl)acetamide(4293-52-1)
• EPA Substance Registry System: N-(1-hydroxybutan-2-yl)acetamide(4293-52-1)

Safety Data

• Hazardous Substances Data: 4293-52-1(Hazardous Substances Data)

Upstream product

• 96-20-8 2-aminobutanol 
• 18312-45-3 propan-2-one O-acetyl oxime 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 132201-63-9 N,O-diacetyl-2-amino-1-butanol 
• 5856-63-3 (2R)-2-aminobutan-1-ol 
• 79-20-9 acetic acid methyl ester 
• 141-78-6 ethyl acetate 
• 108-24-7 acetic anhydride 
• 108-22-5 Isopropenyl acetate 

Relevant articles and documents

Chirality-directed organogel formation

New low molecular mass enantiopure organogelators (1R,4R)-1, (5)-2, (R)-3 and (R)-4 were found; racemates (R,S)-3 and (R,S)-4 have only a moderate gelating power, whereas (R,S)-1 and (R,S)-2 do not show gelating properties at all.

Generation of cyclic ketene-N,X-acetals (X = O, S) from 2-alkyl-1,3-oxazolines and 2-alkyl-1,3-thiazolines. Reactions with acid chlorides, 1,3-diacid chlorides and N-(chlorocarbonyl) isocyanate

2-Alkyl-1,3-oxazolines, 2-alkyl-1,3-thiazolines, and the corresponding cyclic ketene-N,X-acetals (X = O, S) derived from them were reacted with monoacid chlorides, diacid chlorides, triacid chlorides. A series of these carbon-carbon bond-forming reactions and cyclizations to both substituted 2,3-dihydrooxazolo[3,2-a]pyridine-5,7-diones and 2,3-dihydrothiazolo[3,2-a] pyridine-5,7-diones proceeded under mild reaction conditions. Cyclic ketene-N,X-acetal intermediates play important roles in all these reactions. Related cyclizations with N-(chlorocarbonyl) isocyanate formed substituted 2,3-dihydrooxazolo[3,2-c]pyrimidine-5,7-diones and 2,3-dihydrothiazolo[3,2-c] pyrimidine-5,7-diones. Georg Thieme Verlag Stuttgart.

Oxime esters as acylating agents in the aminolysis reaction. A simple and chemoselective method for the preparation of amides from amino alcohols

Oxime esters, such as acetone O-alkanoyl-, O-alkenoyl- or O-benzyloxycarbonyloximes, react with amines under extremely mild conditions to give the corresponding amides in very good yield. When amino alcohols are used a total chemoselectivity is observed.