42967-55-5Relevant academic research and scientific papers
An improved and practical synthesis of tranexamic acid
Li, Zhenhua,Fang, Li,Wang, Jian,Dong, Liuhong,Guo, Yanna,Xie, Yuanyuan
, p. 444 - 448 (2015/03/30)
Tranexamic acid 1, a synthetic antifibrinolytic drug with the treatment being considered highly cost-effective in many countries, has been included in the WHO list of essential medicines. In this paper, we designed the synthesis of 1 via a novel seven-step route from the readily available starting material dimethyl terephthalate, performing with 99.6% purity in 59.2% overall yield. During the process, we successfully developed a direct and efficient method for the preparation of key intermediate methyl 4-(acetamidomethyl)benzoate by one-pot hydrogenation and acylation in acetic anhydride using Ni/Al2O3 as a catalyst. More importantly, it should be a straightforward and practical way to circumvent the usage of toxic reagents (CrO3, Cl2), solvent (CCl4), and expensive catalyst (PtO2), etc., that plagued the previous methodologies.
Thermoplastic polymer composition
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Page/Page column 34; 35, (2015/12/17)
The invention provides a compound conforming to the structure of Formula (C) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (C) as a nucleating agent.
Stable amido peroxycarboxylic acids for bleaching
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, (2008/06/13)
An amido peroxyacid compound is provided having the formula: STR1 wherein R is selected from the group consisting of C1 -C12 alkylene, C5 -C12 cycloalkylene, C6 -C12 arylene and radical combinations thereof; R1 and R2 are independently selected from the group consisting of H, C1 -C16 alkyl and C6 -C12 aryl radicals and a radical that can form a C3 -C12 ring together with R3 and both nitrogens; R3 is selected from the group consisting of C1 -C12 alkylene, C5 -C12 cycloalkylene and C6 -C12 arylene radicals, and provided when R3 is arylene and when n' and m' are each zero, R is other than C5 alkylene; n and n' each are an integer chosen such that the sum thereof is 1; m and m' each are an integer chosen such that the sum thereof is 1; and M is selected from the group consisting of H, alkali metal, alkaline earth metal, ammonium, alkanolammonium cations and radicals and combinations thereof. The amido peroxyacid compound is useful for bleaching substrates such as stained laundry.
Unsymmetrical dicarboxylic esters as bleach precursors
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, (2008/06/13)
A bleach precursor compound, its peroxygen derivative, and detergent compositions containing these materials are disclosed herein. The bleach precursors structurally comprise a pair of different diesters, one ester containing an electrically-charged functional group. Perhydrolysis of the precursor in the presence of hydrogen peroxide and a basic aqueous media generates a peroxycarboxylic acid.
Process for dimerization, arylation and trifluoromethylation of aromatic and heterocyclic compounds
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, (2008/06/13)
A decarboxylation process for coupling aromatic compounds wherein cyclic hydrocarbons and heterocyclic compounds having at least one labile ring hydrogen are reacted with the mono silver salts of aromatic carboxylic acids, or mono silver salts of unsaturated compounds such as α,β-ethylenically unsaturated acid compounds, or silver trifluoroacetate, or the mono silver salts are reacted with themselves, by heating to temperatures of 100° to 500° C. at pressures of 0.1 to 10 atmospheres, or by irradiating the reactants with ultraviolet light of 200 to 400 nanometers at temperatures of -30° to 150° C. The resulting dimers, trimers, polysubstituted polyphenyls, polyheterocyclics and trifluoromethylated aromatics are useful as heat transfer media, as intermediates for high molecular weight polymers, pesticides and petroleum additives, and as scintillation counters.
