43088-67-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-5-methylthieno[2,3-d]pyrimidine is used as a synthetic intermediate for the development of various biologically active compounds. Its presence in the molecular structure of target compounds can contribute to their pharmacological activities, making it an essential component in drug discovery and design.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-5-methylthieno[2,3-d]pyrimidine serves as a building block in the synthesis of agrochemicals with specific biological activities. Its incorporation into the molecular structure of these compounds can enhance their effectiveness in pest control, crop protection, and other agricultural applications.
Used in Research and Development:
4-Chloro-5-methylthieno[2,3-d]pyrimidine is utilized in research laboratories for the exploration of its potential pharmacological activities. Scientists investigate its interactions with biological targets and evaluate its efficacy in various therapeutic areas, contributing to the advancement of new drug candidates.
Used in Specialty Chemicals Production:
This versatile compound is also employed in the production of specialty chemicals and materials. Its unique properties and reactivity make it suitable for various applications, including the development of new materials with specific characteristics for use in different industries.

InChI:InChI=1/C7H5ClN2S/c1-4-2-11-7-5(4)6(8)9-3-10-7/h2-3H,1H3

Upstream product

• 43088-42-2 2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester 
• 43088-64-8 5-methylthieno[2,3-d]pyrimidin-4-ol 
• 43088-64-8 5-Methyl-3,4-dihydrothieno<2,3-d>pyrimid-4-one 

Downstream Products

• 863784-27-4 3-(5-Methyl-thieno[2,3-d]pyrimidin-4-yloxy)-2-phenyl-[1,8]naphthyridine 
• 917907-37-0 2-(5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-phenol 
• 1276690-50-6 5-methyl-4-(phenylethynyl)thieno[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase

A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified.

AlCl3-induced (hetero)arylation of thienopyrimidine ring: a new synthesis of 4-substituted thieno[2,3-d]pyrimidines

AlCl3 facilitated C-C bond forming reaction between 4-chloro-thieno[2,3-d]pyrimidines and (hetero)arenes affording a direct and single-step method for the synthesis of 4-(hetero)aryl substituted thieno[2,3-d]pyrimidines. A number of novel thien

NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel thienopyrimidine derivative having an excellent anti? inflammatory and anti-cancer activity, or a pharmaceutically acceptable salt thereof, a process for the preparation thereof and a pharmaceutical composition comprising the same. The compound according to the present invention strongly inhibits IKB kinase-β (IKK-β) involved in the activation of a transcriptional factor, NF-κB, which is associated with inducing various immune and inflammatory diseases, whereby a composition comprising the compound is a useful therapeutic agent against inflammatory diseases, in particular, arthritis and cancer.

COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

The present invention provides compounds of formula (I) or compounds of formula (II) and pharmaceutically acceptable salts or solvates thereof. An objective of the present invention is to provide compounds having TGF2 inhibitory activity.

SUBSTITUTED AMINOPYRIMIDINES AS NEUROKININ ANTAGONISTS

The invention discloses tachykinin receptor antagonists. The tachykinin family of receptors comprising the neurokinins substance P (SP), neurokinin A, and neurokinin B and related neuropeptides that are widely distributed in the peripheral and central ner

THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS

The present invention provides thienopyrimidine compounds which are potasium channels inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment of arrhythmia are also provided.

INHIBITORS OF FUNGAL INVASION

This invention relates to various anti-fungall agents including agents that are inhibitors of fungal invasion.

Thienopyrimidine derivatives

4-Substituted-thieno[2,3-d], [3,2-d], and [3,4-d]pyrimidines having fungicidal, insecticidal, and miticidal utility are disclosed. Related 3-substituted-thieno[2,3-d], [3,2-d], and [3,4-d]pyrimidin-4-(3H)-imines are useful as fungicides, insecticides, and