43181-77-7

Usage

Chemical class

Belongs to the class of benzo[d]imidazole compounds.

Structure

Contains a benzyl group, a methyl group, and an amine group.

Molecular weight

Approximately 210.28 g/mol (calculated from the molecular formula).

Appearance

Likely a solid or crystalline substance, though specific appearance may vary.

Solubility

Solubility in water and other solvents is not provided, but it may be soluble in organic solvents like methanol or dimethyl sulfoxide (DMSO).

Stability

Stability information is not provided, but it may be sensitive to light, heat, or moisture.

Applications

Often used in medicinal and pharmaceutical research due to its potential biological and pharmacological activities.

Drug development

May have applications in the development of new drugs targeting various diseases or conditions.

Biological processes

Could be involved in the study of various biological processes and mechanisms, though specific processes are not provided.

Further research

The specific properties, potential uses, and mechanisms of action of 1-benzyl-N-methyl-1H-benzo[d]imidazole-2-amine would require additional investigation and research.

Upstream product

• 67-56-1 methanol 
• 43182-10-1 2-amino-1-benzylbenzimidazole 
• 4857-06-1 2-chloro-1H-benzoimidazole 
• 43181-78-8 1-benzyl-2-chlorobenzimidazole 
• 74-89-5 methylamine 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.

Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate

An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl2]2 on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalysts for hydrogen autotransfer process.

Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903

The transient receptor potential cation channel 5 (TRPC5) has been previously shown to affect podocyte survival in the kidney. As such, inhibitors of TRPC5 are interesting candidates for the treatment of chronic kidney disease (CKD). Herein, we report the synthesis and biological characterization of a series of N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors. Work reported here evaluates the benzimidazole scaffold and substituents resulting in the discovery of AC1903, a TRPC5 inhibitor that is active in multiple animal models of CKD.

N-Methylation of Amines with Methanol Catalyzed by a Cp?Ir Complex Bearing a Functional 2,2′-Bibenzimidazole Ligand

A new type of Cp?Ir complex bearing a functional 2,2′-bibenzimidazole ligand was designed, synthesized, and found to be a highly effective and general catalyst for the N-methylation of a variety of amines with methanol in the presence of a weak base (0.3 equiv of Cs2CO3).

General and efficient method for direct N-monomethylation of aromatic primary amines with methanol

The direct N-monomethylation of aromatic primary amines, including arylamines, arylsulfonamides and amino-azoles, using methanol as a methylating agent has been accomplished in the presence of a [CpIrCl2]2/NaOH system. From both synthetic and environmental points of view, the reaction is highly attractive because of low catalyst loading, broad substrate scope and excellent selectivities.

Synthesis of 2-methylaminobenzimidazole derivatives tested for antiinflammatory activity

A series of 1-alkyl substituted 2-methylaminobenzimidazole derivatives was prepared and tested. Some of them were assayed orally in the rat for antiinflammatory and analgesic properties. The compounds did not exhibit any significant activity compared with reference drug levels.