43181-78-8

Usage

Uses

Used in Pharmaceutical Research:
2-Chloro-1-(phenylmethyl)-benzimidazole is used as a potential anti-cancer agent for its possible activity against cancer cells. Its unique structure and functional groups may contribute to its effectiveness in targeting and inhibiting cancer-related pathways.
Used in Organic Synthesis:
2-CHLORO-1-(PHENYLMETHYL)-BENZIMIDAZOLE is used as a building block or intermediate in the synthesis of other organic compounds, potentially leading to the development of new pharmaceuticals or chemical products.
Used in Chemical Research:
2-Chloro-1-(phenylmethyl)-benzimidazole serves as a subject of study in chemical research, where its properties, reactivity, and potential interactions with other molecules can be investigated to expand the understanding of benzimidazole chemistry and its applications.

Upstream product

• 4857-06-1 2-chloro-1H-benzoimidazole 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 615-16-7 1H-benzimidazol-2-ol 
• 5822-13-9 N-benzyl-1,2-phenylenediamine 
• 28643-53-0 1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one 
• 88-74-4 2-nitro-aniline 
• 5729-06-6 N-benzyl-2-nitroaniline 

Downstream Products

• 143257-98-1 lerisetron 
• 250342-76-8 1-benzyl-2-(4'-methoxy-biphenyl-4-yl)-1H-benzoimidazole 
• 75971-14-1 N-(1-methyl-4-piperidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine 
• 14180-45-1 (1-benzyl-2-benzimidazolyl)hydrazine 
• 1393082-69-3 C₃₇H₄₀N₂O₃S 
• 52986-15-9 1-benzyl-2-deuterio-1H-benzo[d]imidazole 
• 111678-96-7 (1-Benzyl-1H-benzoimidazol-2-yl)-(2-chloro-ethyl)-amine 
• 24134-56-3 9-Benzyl-2,3-dihydroimidazo<1,2-a>benzimidazole 
• 86978-99-6 1-Benzyl-2-(2-hydroxyethylamino)-benzimidazole 
• 31493-51-3 N-benzyl-2-mercaptobenzimidazole 
• 51314-51-3 N-butyl-1H-benzo[d]imidazol-2-amine 
• 57897-96-8 1-Benzyl-2-(4-methyl-piperazin-1-yl)-1H-benzoimidazole 

Relevant academic research and scientific papers

Intermolecular [2 + 2] Photocycloaddition of α,β-Unsaturated Sulfones: Catalyst-Free Reaction and Catalytic Variants

2-Aryl-1-sulfonyl-substituted cyclobutanes were prepared in an intermolecular [2 + 2] photocycloaddition from various α,β-unsaturated sulfones and olefins upon irradiation at λ = 300 nm (26 examples, 60-99% yield). Lewis acids catalyzed the [2 + 2] photocycloaddition of 2-benzimidazolyl styryl sulfones. At short wavelengths, the latter substrates underwent C-S bond cleavage but AlBr3 (5 mol %) allowed for an intermolecular reaction with 2,3-dimethyl-2-butene at longer wavelengths. A chiral-at-metal Lewis acid (2 mol %) facilitated an enantioselective reaction (up to 77% ee).

Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903

The transient receptor potential cation channel 5 (TRPC5) has been previously shown to affect podocyte survival in the kidney. As such, inhibitors of TRPC5 are interesting candidates for the treatment of chronic kidney disease (CKD). Herein, we report the synthesis and biological characterization of a series of N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors. Work reported here evaluates the benzimidazole scaffold and substituents resulting in the discovery of AC1903, a TRPC5 inhibitor that is active in multiple animal models of CKD.

Benzoxaborolane compounds and preparation method thereof

The invention relates to benzoxaborolane compounds and pharmaceutically acceptable salts or solvates thereof. The structure of the compounds is shown in the description, wherein B is boron; X is selected from oxygen, sulfur, nitrogen and hydrogen; R1 is s

Highly efficient tandem syntheses of unsymmetrically substituted isomeric S,N-disubstituted-2-mercaptobenzimidazoles

Highly efficient tandem syntheses of unsymmetrically substituted isomeric S,N-disubstituted-2-mercaptobenzimidazoles have been developed. The structures of 6a-d and isomeric compounds 9a-d have been synthesized from 2-mercaptobenzimidazole using tandem synthesis. The structures of 6a-d and isomeric compounds 9a-d have been established by spectral and analytical data, and by unambiguous syntheses.

Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a] benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

A high-throughput (HTS) and high-content screening (HCS) campaign of a commercial library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogues as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which have been known as the causative parasites for visceral leishmaniasis and Chagas disease, respectively. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds 4 and 24 showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, respectively) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 μM, respectively) without serious cytotoxicity toward THP-1 and U2OS cell lines.

Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a] benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

A high-throughput (HTS) and high-content screening (HCS) campaign of a commercial library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogues as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which have been known as the causative parasites for visceral leishmaniasis and Chagas disease, respectively. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds 4 and 24 showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, respectively) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 mM, respectively) without serious cytotoxicity toward THP-1 and U2OS cell lines.

A green and simple synthesis of N-substituted-2-mercaptobenzimidazoles

A green and simple synthesis of N-alkyl-2-mercaptobenzimidazoles 5 (R= CH3, C2H5, CH2Ph) under, different conditions has been developed from N-alkyl-2-chlorobenzimidazole (i.e. CH 3, C2H5, CH2Ph) 4 by reaction with thiourea by physical grinding or by using green solvents like ethanol, PEG-600, etc. or by using micro-wave irradiation technique. Copyright

Ultrasound promoted simple and efficient N-alkylation of 2-substituted benzimidazoles

N-Alkylation of 2-chlorobenzimidazole was carried out using different alkylating agents under ultrasound irradiation technique. These reactions were completed in shorter times and with higher percentage of yields. Among all the green solvents, triethanolamine was found to be very effective and also acts as a base. The above reaction conditions were extended to other 2-substituted benzimidazoles. Thus, a simple and efficient route for N-alkylation has been developed using ultrasound irradiation technique.

Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vi

Synthesis and biological evaluation of [1,2,4]triazino[4,3-a] benzimidazole acetic acid derivatives as selective aldose reductase inhibitors

The acetic acid derivatives of [1,2,4]triazino[4,3-a]benzimidazole (TBI) were synthesized and tested in vitro and in vivo as selective aldose reductase (ALR2) inhibitors. Compound PS11 showed highest inhibitory activity (IC50) 0.32 μM and was f