4382-96-1Relevant articles and documents
Nitration-Peroxidation of Alkenes: A Selective Approach to β-Peroxyl Nitroalkanes
Chen, Yuanjin,Ma, Yangyang,Li, Liangkui,Jiang, Hao,Li, Zhiping
, p. 1480 - 1483 (2019/02/26)
Nitration-peroxidation of alkenes for the synthesis of β-peroxyl nitroalkanes has been developed by using tert-butyl nitrite and tert-butyl hydroperoxide. The method presents a new and selective difunctionalization of alkenes to introduce a nitro group and a peroxyl group across the double bonds of alkenes under mild conditions. A radical reaction pathway is proposed by experimental and theoretical studies.
Diastereotopic fluorine substituents as 19F NMR probes of screw-sense preference in helical foldamers
Pike, Sarah J.,De Poli, Matteo,Zawodny, Wojciech,Raftery, James,Webb, Simon J.,Clayden, Jonathan
, p. 3168 - 3176 (2013/06/04)
Ligating simple amino alcohol or amino ester monomers containing enantiotopic fluorine substituents to the C-terminus of a helical peptide places the fluorine atoms in diastereotopic environments, and gives two distinct and easily identifiable signals in the 19F NMR spectrum. In the case of a dynamically inverting helix built from achiral monomers, the chemical shift separation between the 19F signals provides a simple means of analysing the ratio of screw-sense conformers in the oligomer, in cases where an asymmetric bias leads to a screw-sense preference. The Royal Society of Chemistry 2013.
THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS
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Page/Page column 21, (2010/03/31)
The invention provides compounds of formula I [INSERT CHEMICAL STRUCTURE HERE] (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
