4382-96-1

Usage

Uses

Used in Pharmaceutical Industry:
a-(AMinoMethyl)-a-phenyl-benzeneMethanol is used as a key intermediate in the synthesis of various drugs, contributing to the development of new medications due to its structural properties that allow for modulation of biological pathways and interactions with cellular targets.
Used in Dye Production:
In the dye industry, a-(AMinoMethyl)-a-phenyl-benzeneMethanol is utilized as a precursor for the production of dyes, leveraging its chemical structure to create a range of colorants for different applications.
Used in Specialty Chemicals:
a-(AMinoMethyl)-a-phenyl-benzeneMethanol is also used in the creation of specialty chemicals, where its unique properties are harnessed to produce compounds with specific functions in various industrial applications.
Used in Medicinal Chemistry and Drug Development:
a-(AMinoMethyl)-a-phenyl-benzeneMethanol holds potential in medicinal chemistry and drug development, serving as a modulator of biological pathways, which is crucial for the advancement of novel therapeutic agents targeting specific diseases and conditions.

Upstream product

• 613-91-2 acetophenone oxime 
• 97339-03-2 hydroxy-diphenyl-acetaldehyde-oxime 
• 623-33-6 glycine ethyl ester hydrochloride 
• 459-73-4 GlyOEt*HCl 
• 119-61-9 benzophenone 
• 13280-16-5 N-(diphenylmethylene)methylamine 
• 26199-71-3 2-(Diphenylmethylenamino)-1,1-diphenylaethanol 
• 57728-27-5 2-(2-Hydroxy-2,2-diphenyl-ethylamino)-cyclopent-1-enecarbonitrile 
• 155694-19-2 2-azido-1,1-diphenylethan-1-ol 
• 105-39-5 chloroacetic acid ethyl ester 
• 7475-15-2 2,2-diphenyl-2-hydroxy-1-nitroethane 
• 64-19-7 acetic acid 
• 55275-59-7 N-(2-hydroxy-2,2-diphenylethyl)benzamide 
• 721945-44-4 glycine-(2-hydroxy-2,2-diphenyl-ethylamide) 

Downstream Products

• 451-40-1 phenyl benzyl ketone 
• 947-91-1 Diphenylacetaldehyde 
• 947-90-0 2,2-diphenyl-vinylamine 
• 102603-74-7 (2,2-diphenyl-ethylidene)-(2,2-diphenyl-vinyl)-amine 
• 58811-64-6 N-(2-hydroxy-2,2-diphenyl-ethyl)-acetamide 
• 55275-59-7 N-(2-hydroxy-2,2-diphenylethyl)benzamide 
• 87853-20-1 (2,2-diphenyl-vinyl)-oxalamic acid ethyl ester 
• 87853-11-0 (2-hydroxy-2,2-diphenyl-ethyl)-oxalamic acid ethyl ester 
• 52481-82-0 5,5-diphenyl-oxazolidin-2-one 
• 752257-33-3 4-bromo-benzenesulfonic acid-(2-hydroxy-2,2-diphenyl-ethylamide) 
• 106066-91-5 2-fluoren-9-yl-3-fluoren-9-ylidenemethyl-5,5-diphenyl-oxazolidine 
• 181220-85-9 7a-Methyl-2,2-diphenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 119-61-9 benzophenone 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

Nitration-Peroxidation of Alkenes: A Selective Approach to β-Peroxyl Nitroalkanes

Nitration-peroxidation of alkenes for the synthesis of β-peroxyl nitroalkanes has been developed by using tert-butyl nitrite and tert-butyl hydroperoxide. The method presents a new and selective difunctionalization of alkenes to introduce a nitro group and a peroxyl group across the double bonds of alkenes under mild conditions. A radical reaction pathway is proposed by experimental and theoretical studies.

Synthesis and applications in Henry reactions of novel chiral thiazoline tridentate ligands

Several novel chiral tridentate ligands containing thiazoline were efficiently synthesized from commercially available l=cysteine in high yield. These ligands were subsequently applied to the asymmetric Henry reaction of nitromethane and various aldehydes. It was found that the structures of the thiazoline ligands had a significant influence on the enantioselectivity. It was shown that the optimal catalyst for this reaction was a ligand complexed with CuCl, which was formed from chiral thiazoline with chiral aminoalcohol. At -20°C, with 10 mol% of this ligand, a product with (S)-configuration was isolated in 93% yield and 98% enantiomeric excess.

Diastereotopic fluorine substituents as 19F NMR probes of screw-sense preference in helical foldamers

Ligating simple amino alcohol or amino ester monomers containing enantiotopic fluorine substituents to the C-terminus of a helical peptide places the fluorine atoms in diastereotopic environments, and gives two distinct and easily identifiable signals in the 19F NMR spectrum. In the case of a dynamically inverting helix built from achiral monomers, the chemical shift separation between the 19F signals provides a simple means of analysing the ratio of screw-sense conformers in the oligomer, in cases where an asymmetric bias leads to a screw-sense preference. The Royal Society of Chemistry 2013.

An improved and mild wenker synthesis of aziridines

The conventional Wenker synthesis of aziridines from vicinal amino alcohols has been modified by employing mild reaction conditions. Amino alcohols were converted into their hydrogen sulfates with chlorosulfonic acid. The sulfates were cyclized with sodium hydroxide, and even with non-nucleophilic sodium carbonate. The current, improved method extends the scope of the typical Wenker synthesis and is applicable to unstable amino alcohols in hot sulfuric acid and to unstable sulfates which favor elimination and hydroxide displacement in the presence of strong base. Georg Thieme Verlag Stuttgart.

THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS

The invention provides compounds of formula I [INSERT CHEMICAL STRUCTURE HERE] (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

Synthesis and use of achiral oxazolidine-2-thiones in selective preparation of trans 2,5-disubstituted tetrahydrofurans

The use of achiral N-acetyloxazolidine-2-thiones in the C-glycosylation of lactol acetates has allowed us to prepare with high diastereoselectivity the expected trans 2,5-disubstituted tetrahydrofurans. A study based on the role of the steric hindrance of the N-acetyloxazolidine-2-thiones is reported. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

Synthesis of chiral polydentate ligands and the use of their titanium complexes as pre-catalysts for the asymmetric trimethylsilylcyanation of benzaldehyde

A number of polydentate ligands based on enantiomerically pure binaphthol have been synthesized. The ligand complexes with titanium isopropoxide were used as catalysts for the asymmetric addition of trimethylsilyl cyanide to benzaldehyde. A fragment with axial chirality is responsible for the configuration of O-trimethylsilyl cyanohydrin product. In the case of the optimum ligand based on (R)-binaphthol and (S)-leucinol, an enantiomeric excess of 86% and quantitative yield were achieved in 4 h.

1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines

Starting from (S)-1,1′-binaphthol, a series of ten novel enantiopure 1,1′-binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis.

The oxidation of methylene carbon-carbon double bonds under Fe(III)-TBHP and Fe(III)-TBHP-PA conditions

The oxidation of 1,1-diphenylethylene under Fe(III)-TBHP and Fe(III)-TBHP-Pa conditions followed a pathway alkene to intermediate A to intermediate B to ketone. Intermediate A could be trapped by NaN3.