4404-61-9

Usage

Uses

Used in Perfumery and Personal Care Industry:
Cyclohexyl(diphenyl)methanol is used as a fragrance ingredient for its pleasant aromatic properties, adding a slightly sweet, floral scent to perfumes and personal care products.
Used in Chemical Synthesis:
Cyclohexyl(diphenyl)methanol serves as a chemical intermediate in the production of other organic compounds, contributing to the synthesis of various chemical products.
Used as a Solvent:
cyclohexyl(diphenyl)methanol is also utilized as a solvent, playing a role in dissolving substances and facilitating chemical reactions in different industrial applications.
Safety Note:
It is important to handle cyclohexyl(diphenyl)methanol with care and follow safety guidelines due to its potential to cause skin and eye irritation.

Upstream product

• 119-61-9 benzophenone 
• 931-51-1 cyclohexylmagnesiumchloride 
• 16491-63-7 cyclohexanecarboxylic acid allyl ester 
• 3289-28-9 ethyl cyclohexanecarboxylate 
• 16002-63-4 phenylmagnesium iodide 
• 712-50-5 Cyclohexyl phenyl ketone 
• 110-82-7 cyclohexane 
• 591-50-4 iodobenzene 
• 72399-18-9 formaldehyde O-benzyloxime 
• 629-27-6 1-Iodooctane 
• 623-43-8 crotonic acid methyl ester 
• 626-62-0 Cyclohexyl iodide 
• 97-63-2 methyl methacrylate 
• 558-17-8 tert-Butyl iodide 

Downstream Products

• 30125-24-7 1,1-diphenylmethylenecyclohexane 
• 50585-08-5 (cyclohexylmethylene)dibenzene 
• 102176-79-4 chloro-cyclohexyl-diphenyl-methane 
• 1016565-40-4 C₂₂H₂₇NO₂S 

Relevant academic research and scientific papers

Persistent room temperature blue phosphorescence from racemic crystals of 1,1-diphenylmethanol derivatives

Among the six alkyldiphenylmethanol derivatives assessed in this study, five showed persistent room temperature phosphorescence (pRTP), whereas the original diphenylmethanol (DPhHOH) did not. pRTP is a unique luminescence phenomenon that appears only in t

Synthesis method of diphenylcyclohexylcarbinol

The invention discloses a synthesis method of diphenylcyclohexylcarbinol. The synthesis method sequentially comprises the following steps: adding higher fatty acid or higher fatty acid salt into an organic solvent under the protection of inert gas, adding

Synthesis and application of 2,6-bis(trifluoromethyl)-4-pyridyl phosphanes: The most electron-poor aryl phosphanes with moderate bulkiness

The poor will be rich: BFPy phosphanes (see scheme) mimic the electronic and steric characters of P(C6F5)3 and PPh 3, respectively. These novel ligands showed a large ligand acceleration effect on Stille coupling, the Rh-catalyzed 1,2-addition of aryl boronic acid to unactivated ketones and the asymmetric arylation of N-tosylimine using phenylboronic acid. Copyright

Highly efficient alkylation to ketones and aldimines with Grignard reagents catalyzed by zinc(II) chloride

A highly efficient alkylation to ketones and aldimines with Grignard reagents in the presence of catalytic trialkylzinc(II) ate complexes derived from ZnCl2 (10 mol %) in situ was developed. This simple Zn(II)-catalyzed alkylation could minimize the well-known but serious problems with the use of only Grignard reagents, which leads to reduction and aldol side products, and the yield of desired alkylation products could be improved. Copyright

Triaryl methane derivatives as antiproliferative agents

Clotrimazole (CLT) 1, a synthetic anti-fungal imidazole derivative, inhibits tumor cell proliferation and angiogenesis. In the current study, flow cytometric analysis demonstrated that the decrease in tumor cell growth by CLT 1 was associated with inhibition of cell cycle progression at the G 1-S phase transition, resulting in G0-G1 arrest. A series of CLT 1 analogues has been generated in order to develop CLT 1 derivatives that are devoid of the imidazole moiety which is responsible for the hepatoxicity associated with CLT 1 while retaining CLT 1 efficacy. The majority of these analogues demonstrate in vitro antiproliferative activity ranging from submicromolar to micromolar concentrations.

Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease

The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P, the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.

Hydrocarbon activation. Synthesis of β-cycloalkyl (Di)nitriles through photosensitized conjugate radical addition

Photoinduced hydrogen abstraction from aliphatic cyclic hydrocarbons (C5 to C7, C12, as well as adamantane) by triplet aromatic ketones in the presence of α,β-unsaturated (di)nitriles offers a straightforward entry to the corresponding alkylated (di)nitriles via the alkyl radicals. Yields are moderate to good depending on the olefins structure (substitution in β slows down the addition to mononitriles, but with α,α-dinitriles electronic activation allows efficient alkylation also of β,β-disubstituted substrates). A tandem alkylation - cyclization process has been obtained with (1-methylpent-4-enylidene)malononitrile.

Proximity, photochemical reactivity, and intermolecular 1H-13C cross polarization in benzophenone-d10 and cyclohexane in the zeolite NaX

The photochemistry, photophysics, and solid-state 13C CPMAS NMR of benzophenone and cyclohexane in the zeolite NaX have been analyzed to investigate their proximity, relative mobility, and intermolecular reactivity. Photochemical irradiation of benzophenone in pure cyclohexane yields benzopinacol and benzhydrol as the predominant products. In contrast, irradiation in the solid state leads to 1-cyclohexyl-1,1-diphenylmethanol as the only product by collapse of the radical pair formed after hydrogen abstraction from cyclohexane by excited benzophenone. Phosphorescence analysis at 77 K suggests a highly polar environment, but lack of emission at 300 K in the presence of cyclohexane is assigned to triplet decay via an efficient hydrogen abstraction reaction. Spectral analysis by 13C CPMAS NMR reveals that benzophenone and cyclohexane are adsorbed in an approximate 1:2 ratio. Changes observed in spinning and static samples before and after photolysis are interpreted in terms of molecular motions that are capable of affecting the spectral line width. That benzophenone and cyclohexane share the zeolite supercages in a close packed arrangement was shown by a relatively efficient 1H-13C intermolecular cross polarization from cyclohexane to benzophenone-d10. Comparison of the CPMAS intensities measured with deuterated and nondeuterated benzophenone samples under identical conditions suggest that intermolecular C-D···H-R distances between carbon atoms of deuterated benzophenone and hydrogens of cyclohexane have an average value of ca. 2.2 A?.