6651-39-4

Upstream product

• 66374-47-8 3-trimethylsilanyl-but-3-en-2-ol 
• 75-77-4 chloro-trimethyl-silane 
• 78-93-3 butanone 
• 29173-25-9 1,4-bis(trimethylsilyl)-1-aza-2,5-cyclohexadiene 
• 78-94-4 methyl vinyl ketone 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 

Downstream Products

• 625-33-2 3-penten-2-one 
• 33330-50-6 4-ethoxypentan-2-one 
• 89710-53-2 (2R,3S,4S)-2,3,4-Trimethyl-3-trimethylsilanyloxy-cyclobutanone 
• 4437-50-7 3-methyl-hexane-2,5-dione 
• 53189-98-3 4-Benzyl-4-hydroxy-3-methyl-5-phenyl-pentan-2-one 
• 36075-03-3 4,4-dimethoxy-3-methylbutan-2-one 
• 22104-62-7 4-dimethylamino-3-methylbutan-2-one 
• 77648-94-3 (3S,6R)-3-Hydroxy-3-methyl-6-(1-methyl-2-oxo-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 77648-94-3 (3R,6R)-3-Hydroxy-3-methyl-6-(1-methyl-2-oxo-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 138712-02-4 1-(2,5-dimethylphenyl)butanone 
• 138712-01-3 3-(2,5-dimethylphenyl)butanone 

Relevant academic research and scientific papers

Characterization of covalent Ene adduct intermediates in "hydride equivalent" transfers in a dihydropyridine model for NADH reduction reactions

A study of the reactions of an NADH model, 1,4-di(trimethylsilyl)-1,4- dihydropyridine, 7, with a series of α,β-unsaturated cyano and carbonyl compounds has produced the first direct evidence for an obligatory covalent adduct between a dihydropyridine and substrate in a reduction reaction. The reactions were monitored by NMR spectroscopy. In all reactions studied, the covalent adduct was the first new species detected and its decomposition to form products could be observed. Concentrations of adducts were sufficiently high at steady-state that their structures could be determined directly from NMR spectra of the reaction mixtures; adduct structures are those expected from an Ene reaction between 7 and the substrate. This first reaction step results in transfer of the C4 hydrogen nucleus of 7 to the substrate and formation of a covalent bond between C2 of the dihydropyridine ring and the substrate α-atom. Discovery of these Ene-adduct intermediates completes the spectrum of mechanisms observed in NADH model reactions to span those with free radical intermediates, no detectable intermediates and now covalent intermediates. The geometry of the transition state for formation of the Ene adduct is compared with those of theoretical transition state models and crystal structures of enzyme-substrate/inhibitor complexes to suggest a relative orientation for the dihydropyridine ring and the substrate in an initial cyclic transition state that is flexible enough to accommodate all observed mechanistic outcomes.

A REGIOSPECIFIC SYNTHESIS OF TRIMETHYLSILYL ENOL ETHERS USING RHODIUM CATALYZED ISOMERIZATION OF β-TRIMETHYLSILYLALLYL ALCOHOLS

The rhodium catalyzed isomerization of β-trimethylsilylallyl alcohols has been successfully applied for the regiospecific synthesis of trimethylsilyl enol ethers.

SUR L'OBTENTION HAUTEMENT REGIO- ET STEREOSELECTIVED'ENOXYSILANES PAR ACTION DU BIS(TRIMETHYLSILYL)ACETAMIDE EN MILIEU HMPT SUR LESS DERIVES CARBONYLES ENOLISABLES

The authors describe a new and general method for the preparation of enoxysilanes by silylation of enolizable aldehydes and ketones by use of bis(trimethylsilyl)acetamide in HMPT, in the presence of very small quantities of sodium metal(or another basic a

METHODE SIMPLE POUR LA SYNTHESE RAPIDE ET STEREOSELECTIVE D'ENOXYSILANES D'ALDEHYDES ET DE CETONES

A new highly regio- and stereo-selective method for the preparation of enoxysilanes, viz. treatment of Me3SiCl, NaI, Et3N with enolizable aldehydes and ketones is described.