22563-99-1

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 51-80-9 bis-(dimethylamino)methane 
• 140866-59-7 1,2-diphenyl-3-(N,N-dimethylamino)-2-propen-1-one 
• 124-40-3 dimethyl amine 
• 72223-17-7 1-trimethylsilyloxy-1,2-diphenylethylene 
• 17059-74-4 3-(Dimethylamino)-1,2-diphenyl-2-propen-1-on 
• 4452-11-3 1,2-diphenylprop-2-en-1-one 

Downstream Products

• 95130-60-2 1-Acetamino-1.1-diacetyl-3-phenyl-butyrophenon 
• 95130-77-1 1-Acetamino-1-acetyl-3-phenyl-butyrophenon-carbonsaeure-⁽¹⁾-methylester 
• 7464-67-7 3-N,N-Dimethylamino-1,1,2-triphenyl-propan-1-ol 
• 30669-80-8 (+/-)-2-N,N-dimethylamino-3-phenylpropiophenone 
• 37144-52-8 1,2,5,6-tetraphenyl-1,6-hexanedione 
• 91221-33-9 1-N,N-Dimethylamino-2,3,3-triphenyl-prop-2-en 
• 91221-40-8 4-((Z)-3-Dimethylamino-1,2-diphenyl-propenyl)-phenol 
• 91221-34-0 [(Z)-3-(4-Methoxy-phenyl)-2,3-diphenyl-allyl]-dimethyl-amine 
• 91221-32-8 3-Dimethylamino-1-(4-methoxy-phenyl)-1,2-diphenyl-propan-1-ol 
• 4441-01-4 1,2,4-triphenylbutane-1,4-dione 
• 36372-77-7 1,4,5-triphenyl-1H-pyrazole 
• 2515-51-7 1,3,4-triphenyl-4,5-dihydro-1H-pyrazole 

Relevant academic research and scientific papers

A convenient alternative route to β-aminoketones

Enaminones has been prepared and submitted to conjugate reduction with LAH and the system Al2O3/R2NH to give β-aminoketones. The latter tandem amination system has also been applied in the Mannich reaction, improving the synthesis of several new diaryl β-aminoketones. Besides, the sequential use of DMFDMA and LAH-CuI on deoxybenzoins furnishes a new route for the synthesis of enones.

A CONVENIENT SYNTHESIS OF 1H-1,2,4-TRIAZOL-1-YL-PROPAN-3-ONE DERIVATIVES BY MODIFIED MANNICH REACTION

1H-1,2,4-Triazol-yl-propan-3-ones were synthesized regioselectively using a modified Mannich reaction.Reactions of enones and Mannich bases with imidazole are also described.

MANNICH REACTION UNDER HIGH PRESSURE. DIMETHYLAMINOMETHYLATION OF KETONES WITH BIS(DIMETHYLAMINO)METHANE UNDER MILD CONDITIONS

Dimethylaminomethylation of ketones with bis(dimethylamino)methane takes place cleanly in methanol at room temperature in the kiro bar region.

Carbon-Carbon Bond Formation by the Use of Chloroiodomethane as a C1 Unit. III. A Convenient Synthesis of the Mannich Base from Enol Silyl Ether by a Combination of Chloroiodomethane and N,N,N',N'-Tetramethylmethanediamine

The Mannich dimethylaminomethylation of carbonyl compounds is conveniently carried out via enol trimethylsilyl ethers by a combination of chloroiodomethane (CH2ClI) and N,N,N',N'-tetramethylmethanediamine (TMMD) in DMSO as the solvent at ambient temperatute.The mechanism of the transformation is discussed on the basis of product analysis and 1H NMR spectral studies.The reagent system CH2ClI/TMMD also provides a convenient route to the Eschenmoser's salt ().