4457-67-4

Basic information

• Product Name: 1-Bromo-4-methoxybutane
• Synonyms: omega-Bromobutyl methyl ether;4-METHOXYBUTYL BROMIDE;4-BROMOBUTYL METHYL ETHER;1-BROMO-4-METHOXYBUTANE;4-METHOXYBUTYL BROMIDE 95%;4-BROMOBUTYL METHYL ETHER 95%;4-Methoxybutyl bromide ,95%;1-BroMo-4-Methoxybut
• CAS NO: 4457-67-4
• Molecular Formula: C₅H₁₁BrO
• Molecular Weight: 167.04
• Mol File: 4457-67-4.mol

Chemical Properties

• Boiling Point: 165°C(lit.)
• Flash Point: 59.6 ºC
• Appearance: /
• Density: 1.278
• Vapor Pressure: 3.33mmHg at 25°C
• Refractive Index: 1.4510-1.4550
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Bromo-4-methoxybutane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-methoxybutane(4457-67-4)
• EPA Substance Registry System: 1-Bromo-4-methoxybutane(4457-67-4)

Safety Data

• RIDADR: 1993
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 4457-67-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-4-methoxybutane is used as a reagent and intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the creation of a wide range of medicinal agents, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Bromo-4-methoxybutane serves as a key component in the production of various agrochemicals. Its role in the synthesis of these compounds helps to enhance crop protection and improve agricultural yields.
Used in Fragrance Industry:
1-Bromo-4-methoxybutane is utilized as a reagent in the creation of fragrances, capitalizing on its sweet odor to contribute to the development of various scent profiles for use in perfumes, cosmetics, and other scented products.
Used in Organic Synthesis:
Beyond its applications in specific industries, 1-Bromo-4-methoxybutane is a valuable reagent in organic synthesis, facilitating the production of a diverse array of organic compounds for research and commercial purposes.

InChI:InChI=1/C5H11BrO/c1-7-5-3-2-4-6/h2-5H2,1H3

Upstream product

• 111-32-0 4-methoxybutanol 
• 110-52-1 1,4-dibromo-butane 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 2623-87-2 bromobutyric acid 

Downstream Products

• 109-99-9 tetrahydrofuran 
• 88073-45-4 C₁₈H₂₂O₅S₂ 
• 79786-64-4 N-(4-Methoxy-butyl)-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-N-phenyl-hydrazine 
• 179993-32-9 2-(4-methoxybutoxy)-benzoic acid ethyl ester 
• 61718-80-7 5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one 
• 179995-37-0 2-(4-methoxybutoxy)-terephthalic acid dimethyl ester 
• 61719-01-5 1‐(3,4‐dichlorophenyl)‐5‐methoxypentan‐1‐one 
• 1346603-14-2 1-(4-chlorophenyl)-5-methoxypentan-1-one 
• 61719-49-1 1-(4-bromophenyl)-5-methoxypentan-1-one 
• 57725-41-4 4-(4-methoxybutoxy)-phenol 
• 110526-40-4 1-deuterio-2-(4-methoxybutyl)-3-methyl-2-cyclohexenyl p-nitrobenzoate 
• 110526-14-2 2-(4-methoxybutyl)-3-methyl-2-cyclohexenyl p-nitrobenzoate 
• 110526-32-4 1-deuterio-2-(4-methoxybutyl)-3-methyl-2-cyclohexenol 

Relevant articles and documents

Synthesis of new optically active 2-pyrrolidinones

A new class of optically active 2-pyrrolidinones was synthesized, starting from S-pyroglutamic acid, a well known natural chiral synthon. The synthetic design followed led to the insertion of various substituents at positions 1 and 5 of the 2-pyrrolidinone ring, including the imidazole moiety. Some of them possess two or three stereogenic centers, the configuration of which was retained under the mild conditions used. The new compounds also carry an imidazole moiety, which, along with the 2-pyrrolidinone template, may prove pivotal to several biological processes.

Reduction of carboxylic acids using esters of benzotriazole as high-reactivity intermediates

Herein, we describe a simple and practical protocol for the reduction of carboxylic acids via the in situ formation of hydroxybenzotriazole esters followed by reaction with sodium borohydride to give the corresponding alcohols. The reaction proceeds with excellent yields in the presence of water. Georg Thieme Verlag Stuttgart - New York.

1-substituted, 3-carboxylic acid piperidine derivatives

The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.

Alkyl Ether and Enol Ether Analogs of (Z)-5-Decenyl Acetate, a Pheromone Component of the Turnip Moth, Agrotis segetum: Probing a Proposed Bioactive Conformation for Chain-Elongated Analogs

In order to test a previous conclusion that chain-elongated analogs of (Z)-5-decenyl acetate (1), a pheromone component of the turnip moth, Agrotis segetum, adopt a loop conformation of the terminal alkyl chain in the bioactive conformation, a series of alkyl ether and enol ether analogs of 1 and (Z)-5-dodecenyl acetate (2) have been synthesized and tested using single-cell electrophysiology. In these analogs a methylene group in positions 7 and 9 of 1 and in positions 7 and 11 in 2 have been replaced by an oxygen atom in order to energetically facilitate the formation of a loop conformation in the chain-elongated analogs. The electrophysiological results in combination with molecular mechanics (MM2 and MM3) calculated conformational energies show that the activity decreases of the chain-elongated ether analogs are significantly smaller than that for 2 and that these activity decreases parallel the conformational energies for a loop formation of the terminal chains in the analogs. The results support our previous conclusion that the terminal chain of chain-elongated analogs of 1 adopts a loop conformation in their bioactive conformations.

Anti-ferroelectric liquid crystal and liquid crystal display device

A novel anti-ferroelectric liquid crystal of the formula (I), STR1 wherein: is an integer of 3 to 8, each of X and Y is independently a hydrogen atom or a fluorine atom, Z is --CF3, --CH3 or --C2 H5, q is 0 or 5, m is 0 or 1, n is an integer of 2 to 8, and C* is an asymmetric carbon, provided that when m is 0, q is 0 and n is an integer of 4 to 8 and that when m is 1, q is 5 and z is --CF3, and use of tile above liquid crystal as a liquid crystal display device.

Hydrogen Bonds involving Polar CH Groups. Part 9. Optimum Structural Parameters, and Unequivocal Demonstration of such Intramolecular Interactions in 2-Substituted 1,3-Dithian 1,1,3,3-Tetraoxides

A series of 2-monosubstituted 1,3-dithian 1,1,3,3-tetraoxides have been prepared, having side chains with 2-6 carbon atoms, and bearing alkyl, aryl, methoxy, dialkylamino, and pyridyl terminal substituents, as models for intramolecular C-H...X hydrogen bonds.Methoxy- and amino-substituents, in compounds having two or three carbon atoms in the side chain, show significant intramolecular interaction with the disulphone methine hydrogen in dichloromethane, as evidenced by a downfield shift of the 1H n.m.r. signals; shifts of up to 2.0 p.p.m. have been observed.Intramolecular H-bonds are disrupted in acetone and in pyridine owing to competing intermolecular interactions with the solvents, and in trifluoroacetic acid owing to protonation of the donor atom.