4481-28-1

Usage

Uses

Used in Pharmaceutical Industry:
3-Carboxamidobenzoic acid is used as a building block for the synthesis of various pharmaceutical drugs, particularly for the production of anti-inflammatory and analgesic medications. Its chemical properties allow it to be a crucial component in the development of these therapeutic agents.
Used in Chemical Industry:
In the chemical industry, 3-Carboxamidobenzoic acid is utilized in the synthesis of dyes and pigments, contributing to the coloration and stability of these products. Its ability to undergo various chemical reactions makes it a valuable asset in the creation of a wide range of organic compounds.

InChI:InChI=1/C8H7NO3/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H2,9,10)(H,11,12)

Upstream product

• 106748-24-7 methyl 3-carbamoylbenzoate 
• 75-44-5 phosgene 
• 55-21-0 benzamide 
• 618-47-3 m-toluamide 
• 7446-70-0 aluminium trichloride 
• 1459-93-4 dimethyl Isophthalate 
• 1877-71-0 benzene 1,3-dicarboxylic acid monomethyl ester 
• 925159-45-1 C₁₆H₁₅NO₃ 
• 10388-19-9 m-iodobenzamide 
• 3441-03-0 3-(methoxycarbonyl)benzoyl chloride 

Downstream Products

• 773056-98-7 3-(5-cyclohexylamino-[1,3,4]thiadiazol-2-yl)-benzamide 
• 1111556-37-6 N-(1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide 
• 1337544-62-3 4-amino-5-((2-β-carbamoylbenzamido)-2-methylpropoxy)-2-methylquinoline-3-carboxylic acid 
• 1337544-65-6 ethyl 4-amino-5-((2-β-carbamoylbenzamido)-2-methylpropoxy)-2-methylquinoline-3-carboxylate 
• 1259931-90-2 C₄₁H₄₂F₂N₆O₃ 

Relevant academic research and scientific papers

Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model

Neuropathic pain is a chronic pain caused by a lesion or disease affecting the somatosensory nervous system. To date, no specific treatment has been developed to cure this pain. Antidepressants and anticonvulsant drugs are used, but they do not demonstrate universal efficacy, and they often cause detrimental adverse effects. Some studies highlighted the efficacy of sildenafil, a well-known inhibitor of phosphodiesterase 5 (PDE5, (IC50 = 3.3 nM)), in models of pain. Based on these results, we focused our attention on MY 5445, another known PDE5 inhibitor. Homologues, isosteres and structural analogues of MY 5445 were designed and all synthesized compounds were evaluated for their inhibitory activity toward PDE5. Selectivity profiles towards other PDE1-4 isoenzymes, water solubility and stability in acidic medium of the most potent PDE5 inhibitors were determined and the aminophthalazine 16h and its mimetic 41n (3-aminoindazole)were evaluated in comparison to MY 5445 (4b)in vivo in a model of neuropathic pain induced by sciatic nerve cuffing in mice (3 and 0.5 mg/kg, ip twice a day). Both compounds showed the same efficacy on neuropathic allodynia as MY 5445, and thus produced a significant relief of mechanical hypersensitivity after 12 days of treatment.

Microwave-assisted N-debenzylation of amides with triflic acid

A new and facile microwave-assisted protocol for the debenzylation of N-benzylamides with triflic acid has been developed. Both secondary and tertiary aliphatic or aromatic amides are obtained in moderate to good yields.

Diaminopropionic acid derivatives

A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.

Microsomal metabolism of N,N-diethyl-m-toluamide (DEET, DET): The extended network of metabolites

The aim was to set out to establish the complete network of metabolites arising from the phenobarbital-treated rat liver microsomal oxidation of N,N-diethyl-m-toluamide (DEET). The products formed from DEET and all its subsequent metabolites were identifi