45172-15-4

Usage

Uses

Used in the Agrochemical Industry:
L-Lysine Diisocyanate is used as a key intermediate for the synthesis of various agrochemicals, such as pesticides and herbicides. Its incorporation into these products enhances their effectiveness in controlling pests and weeds, leading to improved crop yields and protection.
Used in the Pharmaceutical Industry:
In the pharmaceutical sector, L-Lysine Diisocyanate is utilized as a building block for the development of new drugs and drug delivery systems. Its unique chemical properties enable the creation of innovative therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in the Dye Industry:
L-Lysine Diisocyanate is also employed as a vital raw material in the production of dyes and pigments. Its reactive nature allows for the synthesis of a diverse array of colorants, which are used in various applications, including textiles, plastics, and printing inks.
Overall, L-Lysine Diisocyanate plays a significant role in multiple industries due to its versatile chemical properties and its ability to be incorporated into a wide range of products.

InChI:InChI=1/C10H14N2O4/c1-2-16-10(15)9(12-8-14)5-3-4-6-11-7-13/h9H,2-6H2,1H3

Synthetic route

phosgene (75-44-5) + Nα, Nε-Bistrimethylsilyl-L-lysin-ethylester (62192-49-8) → L-lysine ethyl ester diisocyanate (45172-15-4)

Conditions	Yield
With triethylamine

polyethylene glycol, PEG400 + D-glucose (50-99-7) + dexamethasone (50-02-2) + L-lysine ethyl ester diisocyanate (45172-15-4) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-ascorbic acid-co-dexamethasone)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; D-glucose; dexamethasone; L-lysine ethyl ester diisocyanate; ascorbic acid In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + glycerol 2-phosphate, free acid (17181-54-3) + D-glucose (50-99-7) + dexamethasone (50-02-2) + L-lysine ethyl ester diisocyanate (45172-15-4) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-ascorbic acid-co-dexamethasone-co-β-glycerophosphate)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; glycerol 2-phosphate, free acid; D-glucose; dexamethasone; L-lysine ethyl ester diisocyanate; ascorbic acid In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + D-glucose (50-99-7) + dexamethasone (50-02-2) + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-dexamethasone)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; D-glucose; dexamethasone; L-lysine ethyl ester diisocyanate In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + D-glucose (50-99-7) + L-lysine ethyl ester diisocyanate (45172-15-4) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-ascorbic acid)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; D-glucose; L-lysine ethyl ester diisocyanate; ascorbic acid In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + glycerol 2-phosphate, free acid (17181-54-3) + D-glucose (50-99-7) + L-lysine ethyl ester diisocyanate (45172-15-4) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-ascorbic acid-co-β-glycerophosphate)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; glycerol 2-phosphate, free acid; D-glucose; L-lysine ethyl ester diisocyanate; ascorbic acid In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + D-glucose (50-99-7) + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; D-glucose; L-lysine ethyl ester diisocyanate In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + glycerol 2-phosphate, free acid (17181-54-3) + D-glucose (50-99-7) + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-β-glycerophosphate)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; glycerol 2-phosphate, free acid; D-glucose; L-lysine ethyl ester diisocyanate In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG200 + L-lysine ethyl ester diisocyanate (45172-15-4) + glycerol (56-81-5) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glycerol-co-polyethylene glycol-co-ascorbic acid)

Conditions	Yield
Stage #1: polyethylene glycol, PEG200; L-lysine ethyl ester diisocyanate; glycerol; ascorbic acid at 20℃; for 120h; In the dark; Stage #2: With water for 0.5h;

LacZ plasmid DNA + polyethylene glycol, PEG400 + O,O'-bis(2-aminopropyl)-polypropylene glycol 300 + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glycerol-co-O,O'-bis(2-aminopropyl)-polypropylene glycol 300-co-Runx2 plasmid DNA)

Conditions	Yield
for 0.166667h;

pIRESneo-Runx2 plasmid DNA + polyethylene glycol, PEG400 + O,O'-bis(2-aminopropyl)-polypropylene glycol 300 + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glycerol-co-O,O'-bis(2-aminopropyl)-polypropylene glycol 300-co-Runx2 plasmid DNA)

Conditions	Yield
for 0.166667h;

α,ω-di(2-propoxyethanol)polydimethylsiloxane + L-lysine ethyl ester diisocyanate (45172-15-4) + sorbitan monostearate (5093-91-4, 96094-21-2) → sugar ester silicone/urethane copolymer

Conditions	Yield
Stage #1: α,ω-di(2-propoxyethanol)polydimethylsiloxane; L-lysine ethyl ester diisocyanate; zinc stearate In 2-methylundecane at 95℃; for 3h; Heating / reflux; Stage #2: sorbitan monostearate In 2-methylundecane at 95℃; for 10h; Stage #3: With ethanol In 2-methylundecane at 80℃; for 3h;

Upstream product

• 75-44-5 phosgene 
• 62192-49-8 N^α, N^ε-Bistrimethylsilyl-L-lysin-ethylester