45172-15-4

Basic information

• Product Name: L-Lysine Diisocyanate
• Synonyms: (S)-Ethyl 2,6-diisocyanatohexanoate;Diisocyanate Ethyl Caproate;2,6-DiisocyanatoEthylCaproate;EthylEsterL-LysineDiisocyanate;Hexanoic acid,2,6-diisocyanato-, ethyl ester, (2S)-;Ethyl (S)-2,6-diisocyanatohexanoate;LDI;L-Lysine diisocyanate ethyl ester
• CAS NO: 45172-15-4
• Molecular Formula: C₁₀H₁₄N₂O₄
• Molecular Weight: 226.22900
• EINECS: 1308068-626-2
• Mol File: 45172-15-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 304.989oC at 760 mmHg
• Flash Point: 125.688oC
• Appearance: Yellow to brown/Viscous Liquid
• Density: 1.128g/cm3
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.4572
• Water Solubility: Sparingly soluble in water (0.19 g/L).
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: L-Lysine Diisocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: L-Lysine Diisocyanate(45172-15-4)
• EPA Substance Registry System: L-Lysine Diisocyanate(45172-15-4)

Safety Data

• HazardClass: 6.1
• Hazardous Substances Data: 45172-15-4(Hazardous Substances Data)

Usage

Uses

It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

InChI:InChI=1/C10H14N2O4/c1-2-16-10(15)9(12-8-14)5-3-4-6-11-7-13/h9H,2-6H2,1H3

Synthetic route

phosgene (75-44-5) + Nα, Nε-Bistrimethylsilyl-L-lysin-ethylester (62192-49-8) → L-lysine ethyl ester diisocyanate (45172-15-4)

Conditions	Yield
With triethylamine

polyethylene glycol, PEG400 + D-glucose (50-99-7) + dexamethasone (50-02-2) + L-lysine ethyl ester diisocyanate (45172-15-4) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-ascorbic acid-co-dexamethasone)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; D-glucose; dexamethasone; L-lysine ethyl ester diisocyanate; ascorbic acid In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + glycerol 2-phosphate, free acid (17181-54-3) + D-glucose (50-99-7) + dexamethasone (50-02-2) + L-lysine ethyl ester diisocyanate (45172-15-4) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-ascorbic acid-co-dexamethasone-co-β-glycerophosphate)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; glycerol 2-phosphate, free acid; D-glucose; dexamethasone; L-lysine ethyl ester diisocyanate; ascorbic acid In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + D-glucose (50-99-7) + dexamethasone (50-02-2) + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-dexamethasone)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; D-glucose; dexamethasone; L-lysine ethyl ester diisocyanate In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + D-glucose (50-99-7) + L-lysine ethyl ester diisocyanate (45172-15-4) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-ascorbic acid)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; D-glucose; L-lysine ethyl ester diisocyanate; ascorbic acid In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + glycerol 2-phosphate, free acid (17181-54-3) + D-glucose (50-99-7) + L-lysine ethyl ester diisocyanate (45172-15-4) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-ascorbic acid-co-β-glycerophosphate)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; glycerol 2-phosphate, free acid; D-glucose; L-lysine ethyl ester diisocyanate; ascorbic acid In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + D-glucose (50-99-7) + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; D-glucose; L-lysine ethyl ester diisocyanate In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG400 + glycerol 2-phosphate, free acid (17181-54-3) + D-glucose (50-99-7) + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glucose-co-polyethylene glycol-co-β-glycerophosphate)

Conditions	Yield
Stage #1: polyethylene glycol, PEG400; glycerol 2-phosphate, free acid; D-glucose; L-lysine ethyl ester diisocyanate In dimethyl sulfoxide at 20℃; for 192h; In the dark; Stage #2: With water In dimethyl sulfoxide for 0.5h;

polyethylene glycol, PEG200 + L-lysine ethyl ester diisocyanate (45172-15-4) + glycerol (56-81-5) + ascorbic acid (50-81-7) → poly(lysine diisocyanate ethyl ester-co-glycerol-co-polyethylene glycol-co-ascorbic acid)

Conditions	Yield
Stage #1: polyethylene glycol, PEG200; L-lysine ethyl ester diisocyanate; glycerol; ascorbic acid at 20℃; for 120h; In the dark; Stage #2: With water for 0.5h;

LacZ plasmid DNA + polyethylene glycol, PEG400 + O,O'-bis(2-aminopropyl)-polypropylene glycol 300 + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glycerol-co-O,O'-bis(2-aminopropyl)-polypropylene glycol 300-co-Runx2 plasmid DNA)

Conditions	Yield
for 0.166667h;

pIRESneo-Runx2 plasmid DNA + polyethylene glycol, PEG400 + O,O'-bis(2-aminopropyl)-polypropylene glycol 300 + L-lysine ethyl ester diisocyanate (45172-15-4) → poly(lysine diisocyanate ethyl ester-co-glycerol-co-O,O'-bis(2-aminopropyl)-polypropylene glycol 300-co-Runx2 plasmid DNA)

Conditions	Yield
for 0.166667h;

α,ω-di(2-propoxyethanol)polydimethylsiloxane + L-lysine ethyl ester diisocyanate (45172-15-4) + sorbitan monostearate (5093-91-4, 96094-21-2) → sugar ester silicone/urethane copolymer

Conditions	Yield
Stage #1: α,ω-di(2-propoxyethanol)polydimethylsiloxane; L-lysine ethyl ester diisocyanate; zinc stearate In 2-methylundecane at 95℃; for 3h; Heating / reflux; Stage #2: sorbitan monostearate In 2-methylundecane at 95℃; for 10h; Stage #3: With ethanol In 2-methylundecane at 80℃; for 3h;

Upstream product

• 75-44-5 phosgene 
• 62192-49-8 N^α, N^ε-Bistrimethylsilyl-L-lysin-ethylester