4537-76-2

Usage

Uses

Used in Pharmaceutical Industry:
1,2-Distearoylphosphatidylethanolamine is used as a key component in the formulation of liposomes for drug delivery. Its amphiphilic nature allows it to form stable lipid bilayers, which can encapsulate and protect therapeutic agents, enhancing their solubility, bioavailability, and targeted delivery to specific cells or tissues.
Used in Cosmetic Industry:
In the cosmetic industry, 1,2-Distearoylphosphatidylethanolamine is used as an emulsifying agent and skin conditioning agent. Its ability to form lipid bilayers helps in stabilizing emulsions and improving the texture and feel of cosmetic products. Additionally, it can help maintain the skin's natural barrier function and provide moisturizing effects.
Used in Food Industry:
1,2-Distearoylphosphatidylethanolamine is utilized as an ingredient in the food industry, particularly in the formulation of fat-based products such as spreads, creams, and sauces. Its emulsifying properties help in stabilizing mixtures and improving the overall texture and mouthfeel of these products.
Used in Nanotechnology:
DSPE is also employed in the development of nanoparticles for various applications, including drug delivery, imaging, and diagnostics. Its ability to form stable lipid bilayers makes it an ideal candidate for the construction of nanoscale structures with potential applications in medicine and biotechnology.

Upstream product

• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 51063-97-9 DL-α,β-distearin 
• 121010-32-0 phosphoric acid-(2-benzyloxycarbonylamino-ethyl ester)-(2,3-bis-stearoyloxy-propyl ester)-phenyl ester 
• 64350-19-2 N-Trityl O-(1,2-disteaoryl-sn-glycero-3-phosphoryl)-ethanolamin 
• 73068-91-4 1,2-Di-O-linolenoyl-sn-glycerin-3-O-phosphoryl-ethanolamin 
• 121075-80-7 3-(((benzyloxy)(2-(((benzyloxy)carbonyl)amino)ethoxy)phosphoryl)oxy)propane-1,2-diyl distearate 
• 57-11-4 stearic acid 
• 1190-00-7 2-aminoethyl 2,3-dihydroxypropyl hydrogen phosphate 
• 638-08-4 stearic anhydride 
• 64350-17-0 Octadecanoic acid 1-octadecanoyloxymethyl-2-{(2,2,2-trichloro-ethoxy)-[2-(trityl-amino)-ethoxy]-phosphoryloxy}-ethyl ester 
• 64350-15-8 Octadecanoic acid 1-octadecanoyloxymethyl-2-[phenylamino-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-ethyl ester 
• 71260-71-4 Octadecanoic acid 2-[hydroxy-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-1-octadecanoyloxymethyl-ethyl ester 
• 34813-39-3 α',β-Dilinolenoyl-N-phthaloyl-α-kephalin 

Downstream Products

• 126695-59-8 4-(hydroxymethyl)-2,3,5,6-tetrafluorophenyl azide 

Relevant academic research and scientific papers

Preparation method of distearoyl phosphatidylethanolamine

The invention provides a preparation method of distearoyl phosphatidylethanolamine, wherein the preparation method comprises the following steps: (1) under alkaline conditions, carrying out amino protection reaction on glyceryl phosphatidylethanolamine represented by a formula (II) and a compound containing an amino protection group to obtain an intermediate a represented by a formula (III); (2) under the action of a catalyst, carrying out acylation reaction on the intermediate a and stearic anhydride to obtain an intermediate b represented by a formula (IV); and (3) under an acidic condition,carrying out an amino protection group removal reaction on the intermediate b to obtain distearoyl phosphatidylethanolamine represented by a formula (V), wherein R in the formula (III), the formula (IV) and the formula (V) represents an amino protection group. The preparation method is simple to operate, high in product yield and easy for industrial production.

New Phosphorylating Agents for the Synthesis of Phosphatidyl ethanolamines

The preparation of three novel phosphorylating agents and their application toward the synthesis of phosphatidylethanolamines is described. These reagents are stable to air and moisture, and phosphorylate glycerols in good yield. The experimental procedures using these phosphorylating agents are simple. Moreover, the appropriate reagent can be selected based on the desired functional groups of the targeted phosphatidylethanolamine.

Synthesis method for positive charge phospholipid

The invention relates to a synthesis method for positive charge phospholipid. 1,2-Palmitodistearin is adopted as a raw material, and phospholipid DSPE is synthesized; then, lysine is connected to an amino of the DSPE; then, n beta-alanines are connected to two aminos of a BOC-lysine group in the product, finally, a salt is obtained, and a series of positive charge phospholipid is obtained.