4537-76-2Relevant articles and documents
Synthesis of artificial group A and B substances.
MASAMUNE,HAKOMORI,NUMABE,AKAMA,KAMIYAMA
, p. 283 - 301 (1955)
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A general synthesis of glycerophospholipids.
Aneja,Chadha,Davies
, p. 102 - 111 (1970)
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Preparation method of distearoyl phosphatidylethanolamine
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, (2021/03/30)
The invention provides a preparation method of distearoyl phosphatidylethanolamine, wherein the preparation method comprises the following steps: (1) under alkaline conditions, carrying out amino protection reaction on glyceryl phosphatidylethanolamine represented by a formula (II) and a compound containing an amino protection group to obtain an intermediate a represented by a formula (III); (2) under the action of a catalyst, carrying out acylation reaction on the intermediate a and stearic anhydride to obtain an intermediate b represented by a formula (IV); and (3) under an acidic condition,carrying out an amino protection group removal reaction on the intermediate b to obtain distearoyl phosphatidylethanolamine represented by a formula (V), wherein R in the formula (III), the formula (IV) and the formula (V) represents an amino protection group. The preparation method is simple to operate, high in product yield and easy for industrial production.