45529-92-8

Basic information

• Product Name: 4,5-dimethyloxazol-2-amine
• Synonyms: 4,5-dimethyloxazol-2-amine;4,5-Dimethyl-oxazol-2-ylamine;4,5-Dimethyl-1,3-oxazol-2-amine hydrochloride;2-Amino-4,5-dimethyloxazole;4,5-dimethyloxazol-2-amine hydrochloride
• CAS NO: 45529-92-8
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.12982
• EINECS: 256-241-9
• Mol File: 45529-92-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 78-79℃ (benzene )
• Boiling Point: 90-110℃ (0.04 Torr)
• Flash Point: 91.8°C
• Appearance: /
• Density: 1.118g/cm³
• Vapor Pressure: 0.0742mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: 2-8°C
• PKA: 6.45±0.14(Predicted)
• CAS DataBase Reference: 4,5-dimethyloxazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dimethyloxazol-2-amine(45529-92-8)
• EPA Substance Registry System: 4,5-dimethyloxazol-2-amine(45529-92-8)

Safety Data

• Statements: 22
• Hazardous Substances Data: 45529-92-8(Hazardous Substances Data)

Usage

General Description

4,5-dimethyloxazol-2-amine is a chemical compound with the molecular formula C5H10N2O. It is an organic compound that belongs to the oxazole class of heterocyclic compounds. This chemical is a derivative of oxazole and contains a dimethylamine substituent on the 4 and 5 positions. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 4,5-dimethyloxazol-2-amine has also been studied for its potential biological activities and pharmacological properties. Overall, this compound has versatile applications in the field of organic chemistry and drug discovery.

InChI:InChI=1/C5H8N2O/c1-3-4(2)8-5(6)7-3/h1-2H3,(H2,6,7)

Upstream product

• 57-13-6 urea 
• 814-75-5 3-bromo-butanone 
• 4091-39-8 3-chloro-2-butanone 
• 420-04-2 CYANAMID 
• 513-86-0 3-hydroxy-2-butanon 
• 21324-75-4 (4,5-dimethyl-oxazol-2-yl)-cyanamide 

Downstream Products

• 35629-37-9 2-acetylamino-4,5-dimethyloxazole 
• 35629-59-5 1-(4-chloro-phenyl)-3-(4,5-dimethyl-oxazol-2-yl)-urea 
• 35629-57-3 1-(2-chloro-phenyl)-3-(4,5-dimethyl-oxazol-2-yl)-urea 
• 35629-58-4 1-(3-chloro-phenyl)-3-(4,5-dimethyl-oxazol-2-yl)-urea 
• 729-99-7 sulphamoxole 
• 191019-49-5 6-(4-Chloro-phenyl)-2,3-dimethyl-imidazo[2,1-b]oxazole 
• 103640-72-8 bis-(N-acetyl-sulfanilyl)-(4,5-dimethyl-oxazol-2-yl)-amine 
• 110490-38-5 (4,5-dimethyl-oxazol-2-yl)-bis-(4-nitro-benzenesulfonyl)-amine 

Relevant articles and documents

Oxazolyl pyrimidinone amide compound or medicinal salt thereof, preparation method and application of oxazolyl pyrimidinone amide compound or medicinal salt thereof

The invention discloses an oxazole pyrimidone amide compound or a pharmaceutically acceptable salt thereof, and a preparation method and application thereof. The oxazole pyrimidone amide compound has the following structural general formula (I) shown in the description, wherein R1 and R2 are respectively and independently selected from hydrogen and C1-3 alkyl, R3 is selected from C1-3 alkyl groups, R4 and R5 are independently selected from 5-6-membered aryl groups, the aryl groups are phenyl groups or heteroaryl groups containing 1-3 heteroatoms, the heteroatoms are selected from oxygen atoms or nitrogen atoms, and the heteroatoms are located at any position on the heteroaryl groups; the aryl is unsubstituted or at least substituted by one or more halogens or C1-3 alkyl groups, C1-3 polyhalogenated alkyl groups and C1-3 alkoxy groups. The invention also discloses an application of the compound as a TRPA1 antagonist, and the compound is used for preparing medicines for treating or preventing diseases, symptoms and/or obstacles regulated by TRPA1, such as pain and the like.

QUINAZOLINE DERIVATIVES

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

S-trifluorobutenyl derivatives and pesticidal uses thereof

S-trifluorobutenyl thiocarbonic acid esters of the formula STR1 and salts thereof, wherein X is R1 N or S and Y is RS or R3 R2 N; wherein R is a metal or a radical selected from alkyl, cycloalkylalkyl, halocycloalkylalkyl, alkenyl, haloalkyl, haloalkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl, alkoxycarbonylalkyl, halophenoxyalkyl, trialkylsilylalkyl, (vinyl)dialkylsilylalkyl, (allyl)dialkylsilylalkyl, 2-chlorothiophene-5-ylmethyl, phenylalkyl, halophenylalkyl, nitrophenylalkyl, haloalkylphenylalkyl, dialkyl-2,3-dihydrobenzofuran-7-yl, [2-methyl-(1,1'-biphenyl)-3-yl]methyl, 3-phenoxybenzyl, phenylthioalkyl, halophenylthioalkyl, dialkylphosphoryl, dialkylthiophosphoryl, dialkylisoxazolylalkyl and thienylisoxazolylalkyl; wherein R1 is alkyl, cycloalkyl, cyano, dialkyl-2,3-dihydrobenzofuran-7-yl, halophenyl, halophenylalkyl, haloalkoxyphenyl, pyridinyl, halopyridinyl, alkyl-1,3,4-thiadiazolyl, haloalkyl-1,3,4-thiadiazolyl, benzothiazolyl, dialkyloxazolyl or thiazolinyl; wherein R2 is hydrogen or alkyl; and wherein R3 is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, dialkylaminoalkyl, dialkyl-2-oxazolyl, 2-thiazolinyl, 2-benzothiazolyl, 4-phenyl-2-thiazolyl, alkyl-1,3,4-thiadiazolyl, haloalkyl-1,3,4-thiadiazolyl, pyridinyl, halopyridinyl, phenyl, halophenyl, halophenylalkyl, haloalkoxyphenyl, or dialkyl-2,3-dihydrobenzofuran-7-yl; provided that: when X is S, Y is R3 R2 N, when X is R1 N, Y is RS, R1 is other than alkyl and R is other than haloalkenyl; and when X is R1 N where R1 is CN and Y is RS, R is other than alkali metal. The compounds exhibit nematicidal and anthelmintic activity and are useful in agriculture and veterinary practice.