4583-58-8Relevant academic research and scientific papers
Water-Compatible Synthesis of 2-Trifluoromethyl-1,3-Dioxanes
Becerra-Figueroa, Liliana,Tiniakos, Alexander F.,Prunet, Jo?lle,Gamba-Sánchez, Diego
supporting information, p. 6929 - 6932 (2018/11/25)
A water-compatible method for the diastereoselective synthesis of 2-trifluormethyl-1,3-dioxanes is described. The reaction proceeds under mild reaction conditions using simple inorganic bases; it has a very good substrate scope and can be performed with different Michael acceptors. Additionally, the reaction products can be further functionalized, showing an excellent perspective for future applications.
Synthesis of α-alkenyl-β-hydroxy adducts by α-addition of unprotected 4-bromocrotonic acid and amides with aldehydes and ketones by chromium(II)-mediated reactions
Wessjohann, Ludger A.,Wild, Harry,Ferreira, Leonildo A.,Schrekker, Henri S.
, p. 674 - 679 (2016/07/19)
The regioselective and diastereoselective chromium(II)-mediated reactions of 4-bromocrotonic acid or amides with aldehydes and ketones can proceed without the need to protect protic sites to generate the respective α-alkenyl-β-hydroxy adducts, i.e. formally the addition of the α-anion of a carboxylic acid or amide to an oxo-compound is featured.
α,β-unsaturated δ-lactones from copper-catalyzed asymmetric vinylogous mukaiyama reactions of aldehydes: Scope and mechanistic insights
Bazan-Tejeda, Belen,Bluet, Guillaume,Broustal, Garance,Campagne, Jean-Marc
, p. 8358 - 8366 (2007/10/03)
A direct regio-, diastereo-, and enantiocontrolled access to α,β-unsaturated δ-lactones is described, based on the reaction of a silyl dienolate and an aldehyde in the presence of 10% of Carreira's catalyst. The scope and limitations of this reaction, as well as mechanistic insights concerning the reactivity of an allyl copper species, are discussed.
A cobalt-phosphine complex as mediator in the formation of carbon-carbon bonds
Orsini,Pelizzoni,Pulici
, p. 1 - 3 (2007/10/02)
The tetrakis(trimethylphospine)cobalt(0) complex, [Co{P(CH3)3}4], in either stoichiometric or catalytic amounts, was shown to be an efficient mediator for a one-pot Reformatsky-type reaction between activated halogen derivatives (esters, amides, lactones) and carbonyl compounds (aldehydes, ketones) to produce a variety of alcohols.
REGIOSELECTIVE CONTROL OF ALLYL ANIONS WITH CADMIUM CHLORIDE: α vs. γ CONDENSATION WITH ALDEHYDES
Bo, Lei,Fallis, Alex G.
, p. 5193 - 5196 (2007/10/02)
A general method for directing the condensation of allyl anions such as 2 with aldehydes preferentially to the γ position of the unsaturated nucleophile is described.The procedure employs cadmium chloride to control the regioselectivity and will facilitat
