4584-23-0

Basic information

• Product Name: 2,2,6-trimethyl-1-oxaspiro[2.5]oct-5-ene
• Synonyms: 2,2,6-trimethyl-1-oxaspiro[2.5]oct-5-ene;1-p-Menthene-4,8-epoxide;4,8-Epoxy-p-menth-1-ene;Terpinolene 4,8-epoxide;Terpinolene oxide
• CAS NO: 4584-23-0
• Molecular Formula: C₁₀H₁₆O
• Molecular Weight: 152.23344
• EINECS: 224-968-0
• Mol File: 4584-23-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 197.5°Cat760mmHg
• Flash Point: 67.3°C
• Appearance: /
• Density: 0.97g/cm³
• Vapor Pressure: 0.53mmHg at 25°C
• Refractive Index: 1.495
• CAS DataBase Reference: 2,2,6-trimethyl-1-oxaspiro[2.5]oct-5-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,6-trimethyl-1-oxaspiro[2.5]oct-5-ene(4584-23-0)
• EPA Substance Registry System: 2,2,6-trimethyl-1-oxaspiro[2.5]oct-5-ene(4584-23-0)

Safety Data

• Hazardous Substances Data: 4584-23-0(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Floral

Common uses

Fragrance industry and flavoring agent in the food industry

Boiling point

High

Flash point

High

Safety precautions

May cause irritation to skin, eyes, and respiratory system if not handled properly.

InChI:InChI=1/C10H16O/c1-8-4-6-10(7-5-8)9(2,3)11-10/h4H,5-7H2,1-3H3

Upstream product

• 5989-54-8 (-)-(S)-limonene 
• 586-62-9 Terpinolene 

Downstream Products

• 1195-32-0 1-methyl-4-isopropenylbenzene 
• 1197-01-9 p-cymene-8-ol 
• 99-87-6 4-methylisopropylbenzene 
• 3419-02-1 4-methyl-1-isopropenylcyclohex-3-en-1-ol 
• 19822-67-4 2,2,5-trimethylcyclohept-4-en-1-one 
• 28233-65-0 1-isopropenyl-4-methyl-1,4-cyclohexadiene 
• 35879-90-4 isokarahanaenone 
• 104841-08-9 2,2,4,4,8-Pentamethyl-1,3-dioxa-spiro[4.5]dec-7-ene 
• 586-62-9 Terpinolene 
• 562-74-3 TERPINEN-4-OL 
• 98-55-5 terpineol 
• 35866-71-8 8-fluoro-p-menth-1-en-4-ol 
• 155048-38-7 1-p-menthene-4-thiol 
• 87128-93-6 4-Methyl-1-(1-chloro-1-methylethyl)-3-cyclo-hexen-1-ol 

Relevant articles and documents

Synthesis of Aristoquinoline Enantiomers and Their Evaluation at the α3β4 Nicotinic Acetylcholine Receptor

The first synthesis of aristoquinoline (1), a naturally occurring nicotinic acetylcholine receptor (nAChR) antagonist, was accomplished using two different approaches. Comparison of the synthetic material's spectroscopic data to that of the isolated alkaloid identified a previously misassigned stereogenic center. An evaluation of each enantiomer's activity at the α3β4 nAChR revealed that (+)-1 is significantly more potent than (-)-1. This unexpected finding suggests that naturally occurring 1 possesses the opposite absolute configuration from indole-containing Aristotelia alkaloids.

PROCESS FOR THE EPOXIDATION OF A TETRASUBSTITUTED ALKENE

This invention relates to a process for the epoxidation of a tetrasubstituted alkene such as terpinolene to the corresponding epoxide such as terpinolene epoxideby reacting the tetrasubstituted alkene with performic acid prepared in situ from formic acid and hydrogen peroxide in the presence of at least one buffering agent. Further, the invention relates to the use of an oxidizing agent comprising hydrogenperoxide and formic acid for the in-situ epoxidation of a tetrasubstituted alkene.

Structure-Odor Activity Studies on Monoterpenoid Mercaptans Synthesized by Changing the Structural Motifs of the Key Food Odorant 1-p-Menthene-8-thiol

1-p-Menthene-8-thiol (1) has been discovered as the key odorant in grapefruit juice several decades ago and contributes to the overall odor of the fruit with an extremely low odor threshold of 0.000034 ng/L in air. This value is among the lowest odor thresholds ever reported for a food odorant. To check whether modifications in the structure of 1 would lead to changes in odor threshold and odor quality, 34 mercapto-containing p-menthane and 1-p-menthene derivatives as well as several aromatic and open-chain mercapto monoterpenoids were synthesized. Eighteen of them are reported for the first time in the literature, and their odor thresholds and odor qualities as well as analytical data are supplied. A comparison of the sensory data with those of 1 showed that hydrogenation of the double bond led to a clear increase in the odor threshold. Furthermore, moving the mercapto group into the ring always resulted in higher odor thresholds compared to thiols with a mercapto group in the side chains. Although all tertiary thiols always exhibited low odor thresholds, none of the 31 compounds reached the extremely low threshold of 1. Also, none of the synthesized mercapto monoterpenoids showed a similar odor quality resembling grapefruit. Although the saturated and aromatic analogues exhibited similar scents as 1, the aromas of the majority of the other compounds were described as sulfury, rubber-like, burned, soapy, or even mushroom-like. NMR and MS data as well as retention indices of the 23 newly reported sulfur-containing compounds might aid in future research to identify terpene-derived mercaptans possibly present in trace levels in foods.