46180-41-0Relevant academic research and scientific papers
Synthesis and application of a novel coupling reagent, ethyl 1-hydroxy- 1H-1,2,3-triazole-4-carboxylate
Jiang, Lu,Davison, Amanda,Tennant, George,Ramage, Robert
, p. 14233 - 14254 (1998)
An optimal coupling reagent, ethyl 1-hydroxy-1H-1,2,3-triazole-4- carboxylate (HOCt), has been designed and synthesised for application to solid phase peptide synthesis using Fmoc chemistry. It is used in combination with carbodiimide reagents, has very high coupling efficiency, and does not absorb at 302nm, thus allowing real-time monitoring of each coupling cycle. Its applications in the synthesis of endothelin analogues and difficult sequences are also discussed.
PREPARATION OF (+/-)-α-ALKYLATED AMINO ACID DERIVATIVES VIA IMIDAZOLES
Lipshutz, Bruce H.,Huff, Bret,Vaccaro, Wayne
, p. 4241 - 4244 (2007/10/02)
Photooxidation of N-methoxy-2,4-disubstituted imidazoles, readily available by way of a three component cyclization followed by O-alkylation, leads to stable acylimines which react with various organomethalics to afford α, α-disubstituted amino acid bis-a
