63104-88-1

Upstream product

• 100-42-5 styrene 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 4122-56-9 methyl o-formylbenzoate 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 103-64-0 bromostyrene 
• 610-97-9 o-iodo-methyl-benzoic acid 

Downstream Products

• 60901-21-5 o-styrylbenzoic acid 
• 907174-66-7 C₁₅H₁₁ClO 
• 21868-93-9 2,3-Diphenyl-3,4-dihydro-isocarbostyril 
• 4679-90-7 3-benzyl-N-phenyl isoindolin-1-one 
• 86770-00-5 (E)-N-phenyl-2-styrylbenzamide 
• 86769-98-4 (E)-N-benzyl-2-styrylbenzamide 
• 86770-01-6 (E)-N-(tert-butyl)-2-styrylbenzamide 
• 86769-97-3 (E)-N-methyl-2-styrylbenzamide 
• 63404-82-0 (E)-2-styrylbenzamide 
• 100954-88-9 (+/?)-trans-4-chloro-3-phenylisochroman-1-one 
• 66374-10-5 (Z)-2-(2-phenylethenyl)benzoic acid 
• 5079-90-3 (E)-2-styrylbenzoic acid 

Relevant academic research and scientific papers

COMPOUNDS FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE

Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.

Synthetic method of toluylene compound

The invention relates to a synthetic method of a toluylene compound. According to the reaction, aryl halide or mixed halides and alkene bromine are used as a substrate. Under the action of a catalyst, a ligand, a reducing agent and an additive, the substrate in ice-water bath is slowly heated to room temperature and a mild reaction is carried out for 8-12 h so as to obtain the toluylene compound. The method has advantages of cheap catalyst metal, mild reaction, one-step reaction, simple step, short reaction time, safe operation, high yield, etc.

Intramolecular Hydroamidation of ortho-Vinyl Benzamides Promoted by Potassium tert-Butoxide/N,N-Dimethylformamide

An intramolecular hydroamidation of ortho-vinyl benzamides had been developed. The reaction was promoted efficiently by potassium tert-butoxide and N,N-dimethylformamide without the need for strong oxidants or transition-metal catalysts. A series of dihyd

Iron catalysis for the synthesis of ligands: Exploring the products of hydrophosphination as ligands in cross-coupling

Catalytic hydrophosphination is a useful technique for the synthesis of phosphines, however, the phosphine products have been little exploited as ligands in catalysis. We have selected three phosphines prepared by iron catalyzed hydrophosphination and used them as ligands in a series of cross-coupling reactions: Heck, Suzuki-Miyaura and Buchwald-Hartwig. Rather than limit the chemistry to simple cross-coupling partners which are almost guaranteed to perform well in these transformations, industrially relevant substrates which are challenging from and electronic and/or steric perspective, along with substrates which contain several heteroatoms, were explored in order to gauge the true potential of these phosphine ligands.

A robust first-pass protocol for the heck-mizoroki reaction

The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.