46843-68-9

Upstream product

• 124730-09-2 N₂-tert-butoxycarbonyl-N₆-benzyl-L-lysine 
• 56-87-1 L-lysine 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 13734-28-6 Boc-Lys-OH 
• 100-52-7 benzaldehyde 
• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 
• 51021-86-4 α-N-Benzyloxycarbonyl-ε-N-benzyl-L-lysin 

Relevant academic research and scientific papers

Method for selective structural modification of L-lysine

The invention belongs to the field of chemical synthesis, and particularly relates to a method for selective structural modification of L-lysine. According to a specific technical scheme in the invention, L-lysine is taken as a raw material, silicon dioxide nanoparticles surface-functionalized by beta-cyclodextrin are taken as a catalyst, water is taken as a solvent, and a reaction is performed for 3-5 hours at 25 DEG C in the presence of an amino protective agent to obtain a final product of the reaction; the final reaction product is subjected to standing, and an upper-layer product is takenand subjected to washing, separating and filtering to obtain selectively-modified L-lysine. The used catalyst is odorless and non-toxic; the synthesis method is simple; catalytic performance is excellent; product separation is easy; the catalyst can be repeatedly used; the method effectively solves the problem that a mixture of a common beta-cyclodextrin catalyzed product and cyclodextrin floatson a liquid level and is difficult to separate, simplifies post-treatment steps, reduces the use amount of an organic solvent, and greatly reduces the amount of waste liquid generated in the stage ofpurification.

Compound N-2-alkanoyl-N-6-benzyl-L-lysine and synthesis method thereof

The invention relates to a novel compound N-2-alkanoyl-N-6-benzyl-L-lysine (hereinafter referred to as compound I) and a synthesis method thereof. The invention provides a series of N-2-alkanoyl-N-6-benzyl-L-lysine compounds of butyryl, valeryl and the like until eicosanoyl. The structural formula of the compound is as shown in a formula (3) of the N-2-alkanoyl-N-6-benzyl-L-lysine, wherein n is ina range of 0-18.

Method for synthesizing N-2-alkyl acyl-N-6-fluorenylmethoxycarbonyl-L-lysine

The invention relates to a method for synthesizing N-2-alkyl acyl-N-6-fluorenylmethoxycarbonyl-L-lysine (hereinafter referred to as compound 1). The method comprises the following steps: taking compound N-2-alkyl acyl-L-lysine and 9-fluorenylmethyl chloroformate as raw materials to react in water or a water-soluble organic solvent or a mixture of the water and the water-soluble organic solvent with an alkali to obtain a reaction solution, concentrating the reaction solution, crystallizing, and filtering to obtain the N-2-alkyl acyl-N-6-fluorenylmethoxycarbonyl-L-lysine, wherein n = 1-18, the N-2-alkyl acyl-N-6-fluorenylmethoxycarbonyl-L-lysine is a straight chain compound; Fmoc is fluorenylmethoxycarbonyl. The synthesis method is simple in reaction, relatively high in yield and purity.