4687-42-7Relevant academic research and scientific papers
Phosphane-mediated domino synthesis of tetrasubstituted furans from simple terminal activated olefins
Wang, Jianfang,Zhou, Rong,He, Zhengjie,He, Zheng-Rong
, p. 6033 - 6041,9 (2020/09/02)
Convenient and highly efficient syntheses of tetrasubstituted furans with flexible substituent patterns from simple and readily available starting materials have been developed. Under very mild conditions, with the mediation of stoichiometric nBu3P, simple terminal activated olefins and acyl chlorides or anhydrides smoothly furnish tetrasubstituted furans in modest to excellent yields. This synthetic strategy features a flexible selection of substituent pattern and a C-acylation/O-acylation/C-acylation/intramolecular Wittig reaction multiple domino assembly sequence. Simplicity can give rise to flexibility and efficiency. Convenient and highly efficient syntheses of tetrasubstituted furans from simple terminal activated olefins through phosphane-mediated multiple domino assembly sequences (such as C-acylation/O-acylation/C-acylation/intramolecular Wittig reaction) have been achieved.
Ionic liquid as catalyst and reaction medium: A Simple and Efficient Procedure for Paal-Knorr furan synthesis
Wang, Gangqiang,Guan, Zhi,Tang, Rongchang,He, Yanhong
experimental part, p. 370 - 377 (2010/04/04)
The ionic liquid 1-butyl-3-methyl-imidazolium hydrogen sulfate, [bmim]HSO4, efficiently catalyzes Paal-Knorr furan synthesis without any organic solvent. A wide range of aliphatic and aromatic 1,4-diketones easily undergo condensations to form furan derivatives, providing a general and convenient procedure. The Paal-Knorr reaction of ester-substituted 1,4-diketones is first reported. The ionic liquid can be recovered and reused for subsequent runs without any appreciable loss of efficiency.
Synthesis of benzo[c] and naphtho[c]heterocycle diesters and dinitriles via homoelongation
Hsu, Dong-Tsou,Lin, Chih-Hsiu
supporting information; experimental part, p. 9180 - 9187 (2010/03/02)
(Chemical Equation Presented) Syntheses of benzo[c] and naphtho[c]heterocycle diesters and dinitriles were achieved via our newly developed iterative elongation protocol. The photophysical and electrochemical properties of these conjugated systems are explored.
Vicinal dianions of diethyl α-aroylsuccinates: Preparation of functionalized-2,3-dihydrofurans and -furans, and diaxial 2,4-diaryl-3,7-dioxabicyclo[3.3.0]octanes
Pohmakotr, Manat,Issaree, Arisara,Sampaongoen, Laddawan,Tuchinda, Patoomratana,Reutrakul, Vichai
, p. 7937 - 7940 (2007/10/03)
Vicinal dianions of diethyl α-aroylsuccinates react with aromatic aldehydes to provide functionalized 2,3-dihydrofurans as the major products together with γ-butyrolactones after treatment of the adducts obtained with a catalytic amount of p-toluenesulfonic acid in refluxing toluene. cis-2,3-Dihydrofurans are used as precursors for the preparation of tetrasubstituted furans and diaxial 2,4-diaryl-3,7-dioxabicyclo[3.3.0]octanes.
