4687-38-1

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 603-35-0 triphenylphosphine 
• 79742-18-0 2-benzoylbut-2-enedioic acid diethyl ester 
• 100-52-7 benzaldehyde 
• 423-39-2 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane 
• 15723-90-7 4-nitrobenzamidine hydrochloride 
• 1121543-12-1 α,α-dibromo-2'-methoxyacetophenone 
• 1114-31-4 diethyl meso-2,3-dibromosuccinate 
• 59726-54-4 diethyl 2,3-dibenzoylbut-2-enedioate 

Downstream Products

• 5446-67-3 5,6,11,12-Tetraoxo-5,5a,6,11,11a,12-hexahydro-naphthacen 
• 4687-42-7 diethyl 2,5-diphenylfuran-3,4-dicarboxylate 
• 128792-96-1 diethyl 4-benzoyl-3,4-dihydro-3-methylene-6-phenyl-2H-pyran-4,5-dicarboxylate 
• 495-71-6 phenacylacetophenone 
• 67560-62-7 2,6-diphenyl-3,7-dioxabicyclo<3.3.0>octane 
• 81581-36-4 threo-2,3-bis-(α-hydroxybenzyl)butane-1,4-diol 
• 60903-90-4 diethyl 2,3-dibenzoylmaleate 
• 59726-54-4 dibenzoyl-fumaric acid diethyl ester 
• 851-33-2 1,2,5-triphenyl-1H-pyrrole 
• 13213-81-5 ethyl 1,2,5-triphenyl-1H-pyrrole-3-carboxylate 
• 29113-66-4 ethyl 2,5-diphenylfuran-3-carboxylate 

Relevant academic research and scientific papers

Ambient-Light-Promoted Three-Component Annulation: Synthesis of Perfluoroalkylated Pyrimidines

An ambient-light-promoted and metal-free three-component reaction of active methylene compounds, perfluoroalkyl iodides, and guanidines/amidines is reported. This constitutes a powerful method to prepare perfluoroalkylated pyrimidines with mild reaction conditions, broad substrate scope, excellent functional group tolerance, and simple operation. A radical/polar mechanism involving the formation of a halogen-bond adduct and radical cross-coupling is proposed.

Method of dehydrogenation self-coupling of 1,3-dicarbonyl compound with visible light catalysis

The invention discloses a method of dehydrogenation self-coupling of a 1,3-dicarbonyl compound with visible light catalysis. The method comprises the following steps of (1) dissolving a photocatalyst,a peroxide and the 1,3-dicarbonyl compound into a solve

Oxidative Coupling of 1,3-Dicarbonyl Compounds by Cerium(IV) Ammonium Nitrate

A fast, mild, and highly efficient method for the intermolecular coupling of 1,3-dicarbonyl compounds using cerium ammonium nitrate in CH 3CN/CH3OH/H2O has been described. The procedure provided a convenient method for the synthesis of 1,4-diketone derivatives with excellent yields (up to 96%) and powerful evidence for the oxidation mechanism mediated by cerium ammonium nitrate. Copyright

Bromophilic substitution/carbophilic substitution cascade reactions of α,α-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles

α,α-Dibromo-2-methoxyacetophenone reacts, under mild reaction conditions, with C-, N- and O-nucleophiles via a bromophilic substitution/protonation/carbophilic substitution cascade process to afford α-monosubstituted-2-methoxyacetophenones in moderate to good yield. The only exception from this reaction pathway is the reaction with the anion derived from malononitrile in which 2-aroyl-1,1,3,3-tetracyanopropene is obtained.

Efficient selective formation of C-C single bonds and C=C double bonds by NBS-promoted oxidative coupling of β-keto esters

A new application of NBS, which results in the oxidative coupling of β-keto esters to selectively form C-C single and C=C double bonds, can be controlled by the amount of NBS and t-BuOK employed. This methodology adds a new entry to C-C single and C=C double-bond formation between active methylene groups under mild conditions with high selectivity. Copyright Taylor & Francis Group, LLC.

ELECTROCHEMICAL OXIDATIVE DIMERIZATION OF ACETOACETIC AND BENZOYLACETIC ESTERS IN THE PRESENCE OF METAL HALIDES

Acetoacetic and benzoylacetic esters dimerize on electrolysis in the presence of metal halide mediators to form 2,5-dioxohexane-3,4-dicarboxylic and 1,4-dioxo-1,4-diphenylbutane-2,3-dicarboxylic esters in yields up to 90percent.Primarily the meso-form of the dimer is produced (up to 90percent) under optimal conditions (NaI, -20 deg C) in acetone and acetonitrile.Diastereomers of the dimer are produced in comparable amounts in methanol and ethanol.

Reaction of Triphenylphosphine Radical Cation with 1,3-Dicarbonyl Compounds: Electrochemical One-Step Preparation of Dioxomethylenetriphenylphosphoranes

Electrochemical oxidation of Ph3P (1) in MeCN in the presence of 1,3-dicarbonyl compounds, R1COCH2COR2 (3), with HClO4 as the supporting electrolyte resulted in the formation of the phosphonium salts, Ph3P+ -CH(COR1)COR2 ClO4- (4), provided that R1 and/or R2 is a phenyl group.On the other hand, electrolysis in CH2Cl2 with 2,6-lutidinium perchlorate gave the phosphoranes, Ph3P=C(COR1)COR2 (5), directly from 1 and 3 in fair to excellent yields: in this case, R1 or R2 need not necessarily be a phenyl group.Thus, the electrolysis is shown to be a convenient method to prepare 5 in a single step.Plausible processes for the formation of 4 and 5 are proposed, involving the reaction of electrochemically generated Ph3P+. with the enol form of 3 as the keystep.Keywords - triphenylphosphine; 1,3-dicarbonyl compound; dioxomethyltriphenylphosphonium perchlorate; dioxomethylenetriphenylphosphorane; electrochemical oxidation; constant current electrolysis

Synthesis and N.m.r. Spectra of 2,6- and 2,4-Diaryl-3,7-dioxabicyclooctanes

A series of isomeric 2,6- and 2,4-diaryl-3,7-dioxabicyclooctanes have been prepared via the corresponding threo, and erythro-dioxo-diesters.Comparison of their 1H and 13C n.m.r. spectra reveals small differences in chemical shifts and coupling constants which could be diagnostic in assigning structures to such compounds.The structure of 4-hydroxysesamin has been confirmed by direct correlation with sesamin.