471905-53-0

Upstream product

• 85117-99-3 2-(bromomethyl)-1,4-difluorobenzene 
• 471903-19-2 5-(4-chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 470716-51-9 2-[[(4-chlorophenyl)sulfonyl]methyl]-1,4-difluorobenzene 
• 470716-52-0 2-[[(4-chlorophenyl)thio]methyl]-1,4-difluorobenzene 
• 106-54-7 p-Chlorothiophenol 
• 852312-96-0 5-(4-chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-oxo-cyclohexanecarboxylic acid methyl ester 
• 471903-20-5 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone 

Relevant academic research and scientific papers

CYCLOHEXYL SULPHONES FOR TREATMENT OF CANCER

Sulphones of formula (I) are disclosed for use in treatment of cancer.

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

The protease γ-secretase plays a pivotal role in the synthesis of pathogenic amyloid-β in Alzheimer's disease (AD). Here, we report a further extension to a series of cyclohexyl sulfone-based γ-secretase inhibitors which has allowed the preparation of hig

The conformational bias of aryl, arylsulfonyl geminally substituted tertiary carbon centers: Applications in substrate-based stereocontrol

Intramolecular nitrile oxide-olefin cycloaddition to form hexahydrobenzisoxazole 14, which engenders a phenylsulfonyl, 2,5-difluorophenyl geminally substituted carbon substructure, proceeds with up to 99% ds. A rationalization of the high level of substra

Aryl sulfones: A new class of γ-secretase inhibitors

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described.

The new cyclohexylpropionic sulfone

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.