47234-64-0

Upstream product

• 405-39-0 N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 75-44-5 phosgene 
• 503-38-8 trichloromethyl chloroformate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 657-27-2 L-Lysine hydrochloride 
• 501-53-1 benzyl chloroformate 
• 56-87-1 L-lysine 
• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 1387552-55-7 C₂₁H₂₄N₂O₆ 

Downstream Products

• 102495-95-4 N⁶-benzyloxycarbonyl-L-lysine hydrazide 
• 59515-43-4 N^ε-benzyloxycarbonyl-L-lysine ethyl ester hydrochloride 
• 116586-26-6 (2S,3aS,7aS)-1-(N⁶-benzyloxycarbonyl-L-lysyl-γ-D-glutamyl)octahydro-1H-indole-2-carboxylic acid 
• 55226-85-2 tetra-(N-carbobenzoxy-L-lysine) 

Relevant academic research and scientific papers

Polymerization of α-amino acid N-carboxyanhydrides catalyzed by rare earth tris(borohydride) complexes: Mechanism and hydroxy-endcapped polypeptides

In this work, rare earth tris(borohydride) complexes, Ln(BH 4)3(THF)3 (Ln = Sc, Y, La, and Dy), have been used to catalyze the ring-opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride (BLG NCA). All the catalysts show high activities and the resulting poly(γ-benzyl-L-glutamate)s (PBLGs) are recovered with high yields (≥90%). The molecular weights (MWs) of PBLG can be controlled by the molar ratios of monomer to catalyst, and the MW distributions (MWDs) are relatively narrow (as low as 1.16) depending on the rare earth metals and reaction temperatures. Block copolypeptides can be easily synthesized by the sequential addition of two monomers. The obtained P(γ-benzyl-L-glutamate- b-μ-carbobenzoxy-L-lysine) [P(BLG-b-BLL)] and P(γ-benzyl-L-glutamate-b- alanine) [P(BLG-b-ALA)] have been well characterized by NMR, gel permeation chromatography, and differential scanning calorimetry measurements. A random copolymer P(BLG-co-BLL) with a narrow MWD of 1.07 has also been synthesized. The polymerization mechanisms have been investigated in detail. The results show that both nucleophilic attack at the 5-CO of NCA and deprotonation of 3-NH of NCA in the initiation process take place simultaneously, resulting in two active centers, that is, an yttrium ALA carbamate derivative [H2BOCH 2(CH)NHC(O)OLni￡] and a N-yttriumlated ALA NCA. Propagation then proceeds on these centers via both normal monomer insertion and polycondensation. After termination, two kinds of telechelic polypeptide chains, that is, α-hydroxyl-ω-aminotelechelic chains and α-carboxylic-ω-aminotelechelic ones, are formed as characterized by MALDI-TOF MS, 1H NMR, 13C NMR, 1H-1H COSY, and 1H-13C HMQC measurements. By decreasing the reaction temperature, the normal monomer insertion pathway can be exclusively selected, forming an unprecedented α-hydroxyl-ω-aminotelechelic polypeptide.

Immunostimulation of tumor microenvironment by targeting tumor-associated macrophages with hypoxia-responsive nanocomplex for enhanced anti-tumor therapy

Tumor-associated macrophages (TAMs), which dampen the therapeutic efficacy of cancer immunotherapy, are the key players in the immunosuppressive tumor microenvironment (TME). Therefore, reprogramming TAMs into tumoricidal M1 macrophages possesses consider

On-POM Ring-Opening Polymerisation of N-Carboxyanhydrides

The ring-opening polymerisation of α-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)—redox-active molecular metal-oxide anions—can serve as inorganic scaffold initiators for such NCA polymerisations. This “On-POM polymerisation” strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)–POM hybrid derivatives that can be used to prevent biofilm formation. This versatile “On-POM polymerisation” method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials.

Cholesteroled polymer (Chol-b-Lys)-based nanoparticles (CL-NPs) confer antibacterial efficacy without resistance

It is imperative to develop innovative and efficient antibacterial agents, on account of the mounting prevalence of complicated infections induced by multidrug-resistant bacteria. In this work, Chol-b-Lys nanoparticles (CL-NPs) with a diameter of 304.9 nm

Alendronate-functionalized hypoxia-responsive polymeric micelles for targeted therapy of bone metastatic prostate cancer

Bone metastasis is one of the leading causes of cancer-related death and remains incurable in spite of great efforts. Bone-targeted nanoparticle-based drug carriers can overcome the difficulties in delivering therapeutic agents to metastatic bone and endo

POLYMER COMPOSITE FOR HELICOBACTER PYLORI RECOGNITION AND COMPOSITION FOR PHOTODYNAMIC THERAPY COMPRISING SAME

The present invention relates to a polymer complex for recognizing Helicobacter pylori and its uses, and in more detail, a water-soluble polymer-photosensitizer complex in which sialyllactose, which selectively binds to the surface of Helicobacter pylori,

Lung gene delivery system and preparation method and application thereof

The invention provides a lung gene delivery system as well as a preparation method and application thereof. The lung gene delivery system has the capability of efficiently overcoming mucus layers andcell membrane barriers. RBP and cis-aconitic anhydride a

Preparation method and application of nanoparticle of ribonucleoprotein compound capable of achieving tumor targeted delivery

The invention discloses a preparation method and application of nanoparticles of a ribonucleoprotein compound capable of achieving tumor targeted delivery. The nanoparticles are formed by self-assembly of a polymer with tumor microenvironment responsivene

Tripterine nanoparticles, preparation method therefor and application

The invention relates to the technical field of macromolecular nano-drugs and particularly relates to tripterine nanoparticles, a preparation method therefor and an application. The tripterine nanoparticles have a structure represented by a formula (I) sh

Multiple-target-point treating micelle for regulating and controlling microenvironment of Alzheimer disease (AD) and preparation method of multiple-target-point treating micelle

The invention belongs to the field of drug preparations, and relates to a multiple-target-point treating micelle for regulating and controlling the microenvironment of Alzheimer disease (AD) and a preparation method of the multiple-target-point treating m