477543-38-7

Basic information

• Product Name: methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetate
• Synonyms: methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetate
• CAS NO: 477543-38-7
• Molecular Weight: 266.299
• Mol File: 477543-38-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetate(477543-38-7)
• EPA Substance Registry System: methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetate(477543-38-7)

Safety Data

• Hazardous Substances Data: 477543-38-7(Hazardous Substances Data)

Upstream product

• 96-32-2 bromoacetic acid methyl ester 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 100-52-7 benzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 389065-48-9 methyl 2-((2-nitrophenyl)amino)acetate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 105-36-2 ethyl bromoacetate 
• 98-88-4 benzoyl chloride 
• 15310-02-8 o-iodobenzanilide 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 1440753-81-0 methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)pent-4-enoate 
• 1440753-85-4 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)pent-4-en-1-ol 
• 4946-06-9 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethanol 
• 92437-42-8 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetic acid 
• 1602747-35-2 N-(3,5-di-tert-butylphenyl)-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetamide 
• 1602747-17-0 N-(5-isopropyl-2-methylphenyl)-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetamide 
• 1602747-38-5 N-(3,5-dichlorophenyl)-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetamide 
• 1602747-39-6 N-(2-tert-butyl-6-methylphenyl)-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetamide 
• 1440753-92-3 1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)pent-4-enyloxy)phenyl)-1H-benzo[d]imidazole 

Relevant articles and documents

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold-Hopping Approach

Astacin metalloproteinases, in particular meprins α and β, as well as ovastacin, are emerging drug targets. Drug-discovery efforts have led to the development of the first potent and selective inhibitors in the last few years. However, the most recent compounds are based on a highly flexible tertiary amine scaffold that could cause metabolic liabilities or decreased potency due to the entropic penalty upon binding to the target. Thus, the aim of this study was to discover novel conformationally constrained scaffolds as starting points for further inhibitor optimization. Shifting from flexible tertiary amines to rigid heteroaromatic cores resulted in a boost in inhibitory activity. Moreover, some compounds already exhibited higher activity against individual astacin proteinases compared to recently reported inhibitors and also a favorable off-target selectivity profile, thus qualifying them as very suitable chemical probes for target validation.

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from Aβ-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD.

BENZIMIDAZOLE DERIVATIVES AS MITOCHONDRIAL FUNCTION MODULATORS

Provided are a benzimidazole derivative modulating mitochondrial functions and having pharmaceutical activity as a neuro-protective agent, and a pharmaceutical composition including the compound as an active ingredient.