478-81-9

Upstream product

• 478-81-9 dl Allomatridin 
• 7446-70-0 aluminium trichloride 
• 478-81-9 15-deoxymatrine 
• 519-02-8 (+)-matrine 
• 123-91-1 1,4-dioxane 
• 64-19-7 acetic acid 
• 53676-12-3 2,3,6,7-tetrahydro-1H,5H-dipyrido[2,1-f;3',2',1'-ij][1,6]naphthyridin-10-one 
• 642-10-4 aldotripiperideine 
• 53798-49-5 dodecahydro-dipyrido[2,1-f;3',2',1'-ij][1,6]naphthyridine 
• 107503-12-8 didehydromatrine 
• 111824-95-4 10-oxo-2,3,6,7-tetrahydro-1H,5H,10H-dipyrido[2,1-f;3',2',1'-ij][1,6]naphthyridine-11-carboxylic acid ethyl ester 
• 875255-99-5 10-oxo-2,3,6,7-tetrahydro-1H,5H,10H-dipyrido[2,1-f;3',2',1'-ij][1,6]naphthyridine-11-carboxylic acid 

Relevant academic research and scientific papers

A simple matrine derivative for the facile syntheses of mesoporous zeolites ITQ-37 and ITQ-43

ITQ-37 and ITQ-43 possessing mesoporous structures have aroused great interest because of their promising applications involving large molecules. However, it is challenging to synthesize these zeolites. Herein, MAS-ITQ-37 and MAS-ITQ-43 with enhanced Si/Ge ratios of 1.7 and 3.0 have been synthesized by using a simple matrine-derived organic structure-directing agent.

Various Bioactivity and Relationship of Structure-Activity of Matrine Analogues

For the first time, the botanic source natural product matrine was reported to have more potent inhibitory activity against tobacco mosaic virus (TMV) than the commercial virucide ribavirin. On the basis of the structural diversity modification strategy, a series of matrine derivatives was synthesized and systematically evaluated for their antiviral activity against TMV, fungicidal activity, and insecticidal activity. As a result, compounds 3 (inhibitory rate 67.3%, 69.5%, 63.7%, 63.0% at 500 μg/mL for in vitro activity, inactivation, curative, and protection activities in vivo, respectively), 16 (66.7%, 60.7%, 63.8%, 68.9% at 500 μg/mL), and 32 (74.6%, 76.9%, 72.3%, 75.7% at 500 μg/mL) were found to have much higher anti-TMV activity than ribavirin (40.8%, 37.5%, 38.2%, 37.7% at 500 μg/mL), even exhibiting as well as NK-007 (70.3%, 66.1%, 68.4%, 67.5% at 500 μg/mL), which was an efficient compound created by our group previously. At the same time, it was found that matrine and its derivatives had a broad spectrum fungicidal activity (14 fungi), especially the inhibition of compound 32 against Phytophthora capsici Leonian reached 96.4% at a concentration of 50 μg/mL. What's more, all compounds exhibited very good insecticidal activity to five kinds of insects (including Mythimna Separate, Helicoverpa Armigera, Ostrinia Nubilalis, Plutella xylostella, and Culex Pipiens Pallens); especially, the inhibition rate of C. Pipiens Pallens of compound 22 could still reach 70% at 1 μg/mL.

Matrine derivative and preparation method thereof and application of matrine derivative in pesticides

The invention relates to a matrine derivative (I) and a preparation method thereof and application of the matrine derivative in the aspects of plant virus prevention and control, insecticidal action and bactericidal action, wherein the significance of all groups in the formula is seen in the description. The matrine derivative shows the particularly excellent anti-plant virus activity and also has the bactericidal activity and the insecticidal activity.

Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine.

A study of the structure of albertine

Albertine, isolated from the epigeal part of Leontice albertii, is the first hydroxyl-containing unsaturated alkaloid of the matrine series. On the basis of a study of its mass and NMR spectra and its conversion into sophoramine and matridine, its structure has been established as 13e-hydroxy-7,11-dehydromatrine.