48042-47-3

Upstream product

• 78-40-0 triethyl phosphate 
• 311-45-5 paraoxon 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 100-52-7 benzaldehyde 
• 110-17-8 (2E)-but-2-enedioic acid 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 495-18-1 Benzohydroxamic acid 
• 54436-53-2 O,O-diethyl (2,4-dinitrophenyl) phosphate triester 
• 288-32-4 1H-imidazole 
• 2303-76-6 sodium diethyl phosphite 
• 814-49-3 diethyl chlorophosphate 
• 327596-81-6 O,O-diethyl-O-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethyl]phosphate 
• 161772-13-0 diethyl 2-methoxy-5-nitrophenyl phosphate 

Downstream Products

• 104911-39-9 C₁₂H₁₄I⁽¹⁺⁾*C₄H₁₀O₄P^(1-) 
• 591-50-4 iodobenzene 
• 104911-41-3 sec-Butylethynyl diethyl phosphate 
• 4397-14-2 4-(hydroxymethyl)-2,6-dimethylphenol 

Relevant academic research and scientific papers

Reinvestigation of the reaction between sodium diethyl phosphite and diethyl phosphorochloridate. Evidence for a SET process in the formation of a direct P(IV)-P(IV) bond

Alkali metal salts of diethyl phosphites act as nucleophiles or electron donors in reactions with diethyl phosphorochloridate. Evidence is provided that formation of the direct P(IV)-P(IV) bond proceeds via a single electron transfer process (SET) from phosphite anion to phosphorochloridate.

Soft nanosystems based on hydroxypiperidinium surfactants as adjuvants and micellar catalysts

Quantitative parameters characterizing aggregation behaviour and wetting effect of 1-(2-hydroxyethyl)-piperidinium surfactants have been obtained. Their ability to act as adjuvants in herbicidal compositions based on clopyralid has been revealed. The kine

Investigation of potential paraoxonase-i inhibitors by kinetic and molecular docking studies: Chemotherapeutic drugs

Background: Metabolic processes in living organisms are closely related to the catalytic activity of enzymes. Changes in enzyme activity cause various diseases e.g., neurological, cancer, metabolic and cardiovascular. Most of the current therapeutic drugs

From the Shelf to the Particle: Preparation of Highly Organic-Functionalized Magnetic Composites via 4-Nitrophenyl Reactive Ester

Preparation of chemically tunable magnetic nanoparticles (MNPs) is of great interest in many technological fields. Although numerous methods have been developed to prepare MNPs coated with functional organic moieties, most of them are complex, multistep, and involve the preparation of a specific ligand to be inserted on the particle surface. Herein, we describe the preparation of MNPs covered with reactive polymer poly(4-nitrophenyl methacrylate). The composite was prepared by the dispersion polymerization of 4-nitrophenyl methacrylate in the presence of magnetite nanoparticles stabilized by oleic acid. The novel material can be easily modified with amines to give chemically stable amide bonds without installation of pH-dependent features in the link. The extent of particle modification is readily monitored by the release of 4-nitrophenol from the polymer using UV-vis spectrophotometry. Good agreement between the degree of functionalization assessed by colorimetry and elemental analysis was obtained, and functionalization up to 3 mmol g-1 is easily attained. To illustrate the applicability of the method for catalyst development, we prepared imidazole-covered MNPs that accelerate the hydrolysis of a model organophosphate, with rate constants approximately 105-fold higher than the spontaneous hydrolysis. The catalyst can be recovered by a magnet and recycled without appreciable loss of catalytic activity.

Mechanistic insight on the catalytic detoxification of Paraoxon mediated by imidazole: Furnishing optimum scaffolds for scavenging organophosphorus agents

Any agricultural growth concomitantly increases the demand for pesticides and there is a major concern in monitoring these agents, in order to identify their indiscriminate use, avoid contamination and also to detect prohibited species. Organophosphorus c

Alkylated 1,4-diazabicyclo[2.2.2]octanes: Self-association, catalytic properties, and biological activity

Aggregation of 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide in the presence of diethyl 4-nitrophenyl phosphate was studied using 1H NMR spectroscopy. The quantitative characteristics of the aggregation were determined. The data obtained were use

Dephosphorylation reactions of mono-, Di-, and triesters of 2,4-dinitrophenyl phosphate with deferoxamine and benzohydroxamic acid

This work presents a detailed kinetic and mechanistic study of biologically interesting dephosphorylation reactions involving the exceptionally reactive nucleophilic group, hydroxamate. We compare results for hydroxamate groups anchored on the simple molecular backbone of benzohydroxamate (BHA) and on the more complex structure of the widely used drug, deferoxamine (DFO). BHA shows extraordinary reactivity toward the triester diethyl 2,4-dinitrophenyl phosphate (DEDNPP) and the diester ethyl 2,4-dinitrophenyl phosphate (EDNPP) but reacts very slowly with the monoester 2,4-dinitrophenyl phosphate (DNPP). Nucleophilic attack on phosphorus is confirmed by the detection of the phosphorylated intermediates formed. These undergo Lossen-type rearrangements, resulting in the decomposition of the nucleophile. DFO, which is used therapeutically for the treatment of acute iron intoxication, carries three hydroxamate groups and shows correspondingly high nucleophilic activity toward both triester DEDNPP and diester EDNPP. This result suggests a potential use for DFO in cases of acute poisoning with phosphorus pesticides.

Hydroxylamine as an oxygen nucleophile. Chemical evidence from its reaction with a phosphate triester

The reaction of hydroxylamine with 2,4-dinitrophenyl diethyl phosphate gives the O-phosphorylated product, which is rapidly converted to hydrazine and nitrogen gas in the presence of the excess of hydroxylamine. The Royal Society of Chemistry.

Laser flash photolysis kinetic studies of enol ether radical cations. Rate constants for heterolysis of α-methoxy-β-phosphatoxyalkyl radicals and for cyclizations of enol ether radical cations

Two series of enol ether radical cations were studied by laser flash photolysis methods. The radical cations were produced by heterolyses of the phosphate groups from the corresponding α-methoxy-β-diethylphosphatoxy or β-diphenylphosphatoxy radicals that

Comparative evaluation of oxidising and nucleophilic properties of some α-nucleophiles

Six α-nucleophiles were evaluated at pH = 8 in an aqueous methanolic solution for their oxidising power towards tetrahydrothiophene, and the nucleophilic properties towards paraoxon. MMPP and m-CPBA are the most versatile reagents and can act as nucleophiles as well as oxidising agents.