4841-85-4

Usage

Uses

Used in Pharmaceutical Industry:
cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester is utilized as a precursor in the production of agrochemicals. Its role in creating effective and targeted pesticides and other agricultural chemicals helps to improve crop yields and protect plants from pests and diseases.
Used in Fine Chemicals Synthesis:
cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester is employed as a building block in the synthesis of fine chemicals. Its versatility in chemical reactions enables the creation of specialty chemicals used in various applications, such as fragrances, dyes, and other high-value products.
Used in Material Production:
cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester is also used in the production of various materials and chemicals, thanks to its potential to form a wide range of chemical structures. Its application in material science can lead to the development of innovative materials with unique properties for use in different industries.
It is crucial to handle cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester with care and to adhere to all safety and handling guidelines to ensure the safety of individuals and the environment during its use in various applications.

Upstream product

• 64-17-5 ethanol 
• 2305-26-2 cis-1,2,3,6-tetrahydrophthalic acid 
• 106-99-0 buta-1,3-diene 
• 141-05-9 Diethyl maleate 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 623-91-6 diethyl Fumarate 
• 77-79-2 3-Sulfolene 

Downstream Products

• 17351-07-4 diethyl cyclohexane-cis-1,2-dicarboxylate 
• 88-98-2 trans-cyclohex-4-ene-1,2-dicarboxylic acid 
• 105249-38-5 cis-cyclohex-4-ene-1,2-dicarboxylic acid dihydrazide 
• 14246-80-1 (1S*,2S*)-cyclohex-4-ene-1,2-dicarbohydrazide 
• 439919-46-7 cis-1,6-dihydroxymethyl-3-cyclohexene 
• 118270-72-7 (1S,2R,4R,5R)-4-Acetoxy-5-phenylselanyl-cyclohexane-1,2-dicarboxylic acid diethyl ester 
• 3470-42-6 cis-8-oxabicyclo<4.3.0>non-3-ene 
• 74725-31-8 C₁₇H₁₅Cl₂N₃O₂ 
• 118270-84-1 (1S,2R,5S)-5-Acetoxy-cyclohex-3-ene-1,2-dicarboxylic acid diethyl ester 
• 118270-73-8 C₂₀H₂₆Cl₂O₆Se 
• 1417340-25-0 C₂₂H₂₄N₂O₇ 
• 1417340-26-1 C₂₃H₂₆N₂O₇ 
• 156293-34-4 C₁₁H₁₆O₅ 
• 15679-28-4 ((1R,6R)-6-(hydroxymethyl)cyclohex-3-enyl)methanol 

Relevant academic research and scientific papers

Synthesis of 1,4-Cyclohexanedimethanol, 1,4-Cyclohexanedicarboxylic Acid and 1,2-Cyclohexanedicarboxylates from Formaldehyde, Crotonaldehyde and Acrylate/Fumarate

Valuable polyester monomers and plasticizers—1,4-cyclohexanedimethanol (CHDM), 1,4-cyclohexanedicarboxylic acid (CHDA), and 1,2-cyclohexanedicarboxylates—have been prepared by a new strategy. The synthetic processes involve a proline-catalyzed formal [3+1+2] cycloaddition of formaldehyde, crotonaldehyde, and acrylate (or fumarate). CHDM is produced after a subsequent hydrogenation step over a commercially available Cu/Zn/Al catalyst and a one-pot hydrogenation/oxidation/hydrolysis process yields CHDA, whereas 1,2-cyclohexanedicarboxylate is obtained by a Pd/C-catalyzed tandem decarbonylation/hydrogenation step.

Novel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu

The synthesis of a series of novel 3,4-cis- and 3,4-trans-substituted carbocyclic nucleoside analogs from protected uracil and thymine is described. The key reaction in the followed synthetic protocols utilized the Mitsunobu reaction to couple 3,4-substit

[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES

The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.

INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES

Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

Triflimide activation of a chiral oxazaborolidine leads to a more general catalytic system for enantioselective Diels-Alder addition

The strong acid triflimide ((CF3SO2)2NH) protonates chiral oxazaborolidines to form superactive, stable, chiral Lewis acids which are highly effective catalysts for a wide variety of enantioselective Diels-Alder reactions, documented herein by more than 20 examples. Copyright

Crown ethers derived from cyclohexane. Influence of their stereochemistry in complexation and transport

Crown ethers derived from cyclohexane have been prepared. The trans stereochemistry of the substituents on the carbocyclic ring makes that only one conformation can complex cations. The influence of the stereochemistry in complexation has been studied.

A Useful Preparation of Pyrroles from α,β-unsaturated Sulfones

The addition of alkyl isocyanoacetate to α,β-unsaturated sulfones, which are easily obtained from olefins, affords a convenient access to pyrroles with unusual substitution patterns.

Conformational Equilibrium in 8-Methyl-cis-2-thiahydrindane and 8-Methyl-cis-2-oxahydrindane by 13C NMR Spectroscopy

The preferred conformation of 8-methyl-cis-thiahydrindane has been both estimated by 13C NMR chemical shifts and determined by low temperature 13C NMR spectroscopy to be the conformer with the methyl group equatorial with respect to the cyclohexane ring.This result is in disagreement with the interpretation of the temperature dependence of the CD spectra of (+) and (-) 8-methyl-cis-2-thiahydrindane, whereby the conformation with the methyl group axial with respect to the cyclohexane ring was claimed to be the preferred conformation.The preferred conformation of the related oxygen heterocycle, 8-methyl-cis-2-oxahydrindane, has been estimated by 13C NMR chemical shifts to be the conformer with the methyl group axial with respect to the cyclohexane ring.Possible reasons for these observations are discussed.