4841-85-4

Basic information

• Product Name: cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester
• Synonyms: cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester;Diethyl cis-4-Cyclohexene-1,2-dicarboxylate;Diethyl cis-4-Cyclohexene-1,2-dicarboxylate
• CAS NO: 4841-85-4
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.27
• Mol File: 4841-85-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 114 °C / 1mmHg
• Flash Point: 138.1°C
• Appearance: /
• Density: 1.08
• Refractive Index: 1.4610 to 1.4650
• CAS DataBase Reference: cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester(4841-85-4)
• EPA Substance Registry System: cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester(4841-85-4)

Safety Data

• Hazardous Substances Data: 4841-85-4(Hazardous Substances Data)

Usage

General Description

Cis-4-Cyclohexene-1,2-dicarboxylic acid diethyl ester is a chemical compound that is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. It is a colorless to yellow liquid with a fruity odor and is soluble in most organic solvents. cis-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester is used as a building block in the production of various materials and chemicals, and it has the potential to be used in a wide range of applications in different industries. It is important to handle this compound with care and to follow all safety and handling guidelines when working with it.

Upstream product

• 106-99-0 buta-1,3-diene 
• 623-91-6 diethyl Fumarate 
• 64-17-5 ethanol 
• 77-79-2 3-Sulfolene 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 141-05-9 Diethyl maleate 
• 2305-26-2 cis-1,2,3,6-tetrahydrophthalic acid 

Downstream Products

• 17351-07-4 diethyl cyclohexane-cis-1,2-dicarboxylate 
• 88-98-2 trans-cyclohex-4-ene-1,2-dicarboxylic acid 
• 105249-38-5 cis-cyclohex-4-ene-1,2-dicarboxylic acid dihydrazide 
• 14246-80-1 (1S*,2S*)-cyclohex-4-ene-1,2-dicarbohydrazide 
• 3470-42-6 trans-8-oxabicyclo<4.3.0>non-3-ene 
• 15679-28-4 ((1R,6R)-6-(hydroxymethyl)cyclohex-3-enyl)methanol 
• 156293-34-4 C₁₁H₁₆O₅ 
• 1417340-26-1 C₂₃H₂₆N₂O₇ 
• 1417340-25-0 C₂₂H₂₄N₂O₇ 
• 118374-49-5 C₂₀H₂₆Cl₂O₆Se 
• 118270-85-2 (1S,2S,5S)-5-Acetoxy-cyclohex-3-ene-1,2-dicarboxylic acid diethyl ester 
• 118270-73-8 C₂₀H₂₆Cl₂O₆Se 

Relevant articles and documents

Synthesis of 1,4-Cyclohexanedimethanol, 1,4-Cyclohexanedicarboxylic Acid and 1,2-Cyclohexanedicarboxylates from Formaldehyde, Crotonaldehyde and Acrylate/Fumarate

Valuable polyester monomers and plasticizers—1,4-cyclohexanedimethanol (CHDM), 1,4-cyclohexanedicarboxylic acid (CHDA), and 1,2-cyclohexanedicarboxylates—have been prepared by a new strategy. The synthetic processes involve a proline-catalyzed formal [3+1+2] cycloaddition of formaldehyde, crotonaldehyde, and acrylate (or fumarate). CHDM is produced after a subsequent hydrogenation step over a commercially available Cu/Zn/Al catalyst and a one-pot hydrogenation/oxidation/hydrolysis process yields CHDA, whereas 1,2-cyclohexanedicarboxylate is obtained by a Pd/C-catalyzed tandem decarbonylation/hydrogenation step.

[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES

The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.

Triflimide activation of a chiral oxazaborolidine leads to a more general catalytic system for enantioselective Diels-Alder addition

The strong acid triflimide ((CF3SO2)2NH) protonates chiral oxazaborolidines to form superactive, stable, chiral Lewis acids which are highly effective catalysts for a wide variety of enantioselective Diels-Alder reactions, documented herein by more than 20 examples. Copyright