3470-42-6

Basic information

• Product Name: 1,3,3a,4,7,7a-hexahydro-2-benzofuran
• CAS NO: 3470-42-6
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.1803
• Mol File: 3470-42-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 178.1°C at 760 mmHg
• Flash Point: 54.3°C
• Density: 0.993g/cm³
• Vapor Pressure: 1.36mmHg at 25°C
• Refractive Index: 1.49
• CAS DataBase Reference: 1,3,3a,4,7,7a-hexahydro-2-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,3a,4,7,7a-hexahydro-2-benzofuran(3470-42-6)
• EPA Substance Registry System: 1,3,3a,4,7,7a-hexahydro-2-benzofuran(3470-42-6)

Safety Data

• Hazardous Substances Data: 3470-42-6(Hazardous Substances Data)

Usage

Physical state

Colorless, volatile liquid

Odor

Faint, pleasant

Uses

Flavoring and fragrance agent in food and cosmetic industries, solvent in chemical reactions, starting material for synthesis of other compounds

Safety

Relatively safe for use in consumer products

Toxicity

Low toxicity

Environmental impact

Minimal environmental impact when used in appropriate concentrations

Handling and storage

Proper handling and storage procedures should be followed to ensure safety

Upstream product

• 1708-29-8 2,5-dihydrofuran 
• 106-99-0 buta-1,3-diene 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 4841-85-4 trans-1,2-bis(ethoxycarbonyl)-4-cyclohexene 
• 10479-72-8 trans-2-Chlormethyl-1-hydroxymethyl-cyclohexen-4 
• 13149-04-7 (rac)-trans-4,5-bis(hydroxymethyl)cyclohex-1-ene 
• 4841-85-4 cis-4-cyclohexene-1,2-dicarboxylic acid diethyl diester 
• 10479-72-8 ((1S,6R)-6-Chloromethyl-cyclohex-3-enyl)-methanol 
• 439919-46-7 cis-1,6-dihydroxymethyl-3-cyclohexene 

Downstream Products

• 1354698-49-9 (1R,2S,3R,4S,5S,6R)-5,6-bis(acetoxymethyl)cyclohexane-1,2,3,4-tetrayl tetraacetate 
• 1354698-52-4 (1R,2S,3R,4S,5R,6S)-5,6-bis(acetoxymethyl)cyclohexane-1,2,3,4-tetrayl tetraacetate 
• 259670-50-3 meso-3,4-di-t-butyldiphenylsiloxy-8-oxabicyclo[4.3.0]nonane 
• 259670-55-8 C₂₂H₂₂O₆ 
• 259670-59-2 C₂₂H₂₀O₆ 
• 259670-51-4 meso-3,4-dibenzoyloxy-8-oxabicyclo[4.3.0]nonane 

Relevant articles and documents

Stereoselective synthesis of new rac-quercitols containing hydroxymethyl groups as glucosidase inhibitors

Stereoselective and efficient synthesis of hydroxymethyl-substituted rac-quercitols (13–15) was achieved, starting from cis-furan (Kobayashi, 2008) with photooxygenation reaction, which is readily available by the reduction of cis-phtalic anhydride. α- and β-Glucosidase enzyme activity of the target molecules was evaluated and good inhibitor activity was seen. One- and two-dimensional NMR spectroscopy, IR spectroscopy and X-ray crystallography were utilized in the structure characterization of products.

Synthesis of bishomoinositols and an entry for construction of a substituted 3-oxabicyclo[3.3.1]nonane skeleton

1,3,3a,7a-Tetrahydro-2-benzofuran was used as key compound for the synthesis of various bishomoinositol derivatives. The diene was subjected to an epoxidation reaction for further functionalization of the diene unit. The bisepoxide obtained was submitted

Application of oxidative desymmetrization of meso-tetrahydrofurans: Syntheses of functionalized chiral building blocks and of (-)-alloyohimbane

Oxidative desymmetrization of oxygen functionalized mesotetrahydrofurans was successfully achieved (up to 87% ee) through (salen)manganese(III) catalyzed enantiotopic selective C-H oxidation. The enantioselective synthesis of (-)-alloyohimbane (12) has also been achieved in a short step by using oxidative desymmetrization of meso-tetrahydrofuran as the key step.